SavedAdd your journal

Journals / Balkan Medical Journal / 2012 / Cilt: 29 - Sayı: 1

Hepatit B ve C' li hastalarda idrarda oksidatif stres göstergeleri

Oxidative stress biomarkers in urine of patients with hepatitis B and C

Bülent KANTARÇEKEN
Filiz ATALAY
Hasan UÇMAK
Ergül KURUTAŞ BELGE
Nurettin KUZHAN
Ömer Faruk KÖKOĞLU
Ali ÇETİNKAYA
Remzi TOPRAK
Pages
39–42
Publication Date
2022-10-11
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

It was higher in HCV patients than HBV patients (p

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Objective: The aim of our study is to determine the role of oxidative stress biomarkers in hepatic damage in hepatitis B virus (HBV) and hepatitis C virus (HCV)-infected patients.
📊
Key Findings & Data:Materials and Methods: Forty-eight patients with chronic hepatitis B, 15 patients with chronic hepatitis C and 30 healthy individuals as a control group were included in this study.
💡
Conclusion & Impact:It was higher in HCV patients than HBV patients (p
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Objective: The aim of our study is to determine the role of oxidative stress biomarkers in hepatic damage in hepatitis B virus (HBV) and hepatitis C virus (HCV)-infected patients. Materials and Methods: Forty-eight patients with chronic hepatitis B, 15 patients with chronic hepatitis C and 30 healthy individuals as a control group were included in this study. Serum alanine-aminotransferase (ALT) and aspartate aminotransferase (AST) levels, urine oxidative stress biomarkers such as malondialdehyde (MDA) levels, superoxide dismutase (SOD-1) and catalase (CAT) activities were measured. Results: Urine MDA levels increased in patients with HBV and HCV compared to the control group. It was higher in HCV patients than HBV patients (p

Özet

Amaç: Bu çalışma da, HBV ve HCV infeksiyonlu hastalarda karaciğer hasarı üzerine oksidatif stres biyomarkırlarının rolünün saptanması amaçlandı. Hastalar ve Yöntemler: Kronik hepatit B’li 48, Kronik hepatit C’li 15 hasta ve 30 sağlıklı birey kontrol grubu olarak çalışmaya alındı. Kontrol ve hasta gruplarının serumlarında alanin-aminotransferaz (ALT) ve aspartat-transferaz (AST) düzeyleri, idrarda katalaz (CAT), süperoksit dismütaz (SOD-1) aktiviteleri ve malondialdehit (MDA) düzeyleri ölçüldü. Bulgular: İdrar MDA düzeylerinin HBV ve HCV’li hastalarda kontrol grubuna göre artttığı tespit edildi. HCV’li hastalarda MDA düzeyleri HBV’li hastalara göre daha yüksekti (p

🔖

Cite This Article

KANTARÇEKEN, B., ATALAY, F., UÇMAK, H., BELGE, E. K., KUZHAN, N., KÖKOĞLU, Ö. F., ÇETİNKAYA, A., TOPRAK, R. (2022). Hepatit B ve C' li hastalarda idrarda oksidatif stres göstergeleri. Balkan Medical Journal, Cilt: 29 - Sayı: 1, 39–42. https://ajindex.com/articles/461652

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (5)

  1. Halliwell B, Gutteridge JM, Cross CE. Free radicals, antioxidants, and human disease: where are we now? J Lab Clin Med 1992;119:598-620
  2. Sies H. Strategies of antioxidant defences. Eur j Biochem 1993;215:213-9. [CrossRef] 3. Larrea E, Beloqui O, Munos-Navas MA, Civeira MP, Prieto J. Superoxide dismutase in patients with chronic hepatitis C virus infection. Free Radic Biol Med 1998;24:1235-41. [CrossRef] 4. Parola M, Robino G. Oxidative stress related molecules and liver fibrosis. J Hepatol 2001;35:297-306. [CrossRef] 5. Poli G. Pathogenesis of liver fibrosis: role of oxidative stress. Mol Aspects Med 2000;21:49-98. [CrossRef] 6. Broide E, Klinowski E, Koukoulis G, Hadzic N, Portmann B, Baker A, et al. Superoxide dismutase activity in children with chronic liver diseases. J Hepathol 2000;32:188-92. [CrossRef] 7. Britton RS, Bacon BR. Role of free radicals in liver diseases and hepatic fibrosis. Hepatogastroenterology 1994;41:343-8
  3. Fridovich I. Superoxide dismutase. Adv Enzymol Relat Areas Mol Biol 1974;41:35-97
  4. Beutler, E. Red Cell Metabolism. A manual of biochemical methods. 2nd edition, Grune and Stratton Inc., New York; 1984
  5. Ohkawa H, Ohishi N, Yagi K. Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal Biochem 1979;95:351-8. [CrossRef] 11. Irshad M, Chaudhuri PS, Joshi YK. Superoxide dismutase and total anti-oxidant levels in various forms of liver diseases. Hepatol Res 2002;23:178-84. [CrossRef] 12. De Maria N, Colantoni A, Fagiuoli S, Liu G-J, Rogers BK, Farinati F, et al. Association between reactive oxygen species and diseaseactivity in chronic hepatitis C. Free Radic Biol Med 1996;21:291-5. [CrossRef] 13. Paradis V, Mathurin P, Kollinger M, Imbert-Bismut F, Charlotte F, Piton A, et al. In situ detection of lipid peroxidation in chronic hepatitis C: correlation with pathological features. J Clin Pathol 1997;50:401-6. [CrossRef] 14. Boya P, de la Peña A, Beloqui O, Larrea E, Conchillo M, Castelruiz Y, et al. Antioxidant status and glutathione metabolism in peripheral blood mononuclear cells from patients with chronic hepatitis C. J Hepatol 1999;31:808-14. [CrossRef] 15. Romero MJ, Bosch-Morell F, Romero B, Rodrigo JM, Sera MA, Romero FJ. Serum malondialdehyde: possible use for the clinical management of chronic hepatitis C patients. Free Radic Biol Med 1998;25:993-7. [CrossRef] 16. Chrobot AM, Szaflarska-Szczepanik A, Drewa G. Antioxidant defense in children with chronic viral hepatitis B and C. Med Sc