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Journals / Balkan Medical Journal / 2013 / Cilt: 30 - Sayı: 1

Protective effects of erythropoietin and n-acetylcysteine on methotrexate-induced lung injury in rats

Hasan KAHRAMAN
Nurhan KÖKSAL
Ergül KURUTAŞ
Harun ÇIRALIK
Mahmut TOKUR
Selim BOZKURT
Betül KABAKCI
Vedat BALKAN
Pages
99–104
Publication Date
2022-10-11
DOI
—
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In group MTX both scores were significantly higher than in sham (p

📌 3 Key Takeaways

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Objective & Hypothesis:Objective: Methotrexate (MTX) is known to have deleterious side effects on lung tissue.
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Key Findings & Data:Material and Methods: Twenty-six female Sprague-Dawley rats were divided into 4 groups.
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Conclusion & Impact:In group MTX both scores were significantly higher than in sham (p
🔬Design:Research Article
📍Scope:2000 Verileri
⚙️Variables:Domain Parameters

Abstract

Objective: Methotrexate (MTX) is known to have deleterious side effects on lung tissue. We aimed to investigate the effects of erythropoietin (EPO) and N-acetyl-cysteine (NAC) on MTX-induced lung injury in rats. Study Design: Animal experiment. Material and Methods: Twenty-six female Sprague-Dawley rats were divided into 4 groups. Sham group, 0.3 mL saline; MTX group, 5 mg/kg MTX; EPO group, 5mg/kg MTX and 2000 IU/kg EPO; NAC group, 5 mg/kg MTX and 200 mg/kg NAC were administered once daily for 4 consecutive days. Malondialdehyde (MDA), superoxide dismutase (SOD), catalase (CAT) and inflammation and congestion scores in lung tissues were evaluated. Results: In MTX group MDA were significantly higher, CAT and SOD were significantly lower than in sham, EPO and NAC groups (p0.005). In group MTX both scores were significantly higher than in sham (p

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Cite This Article

KAHRAMAN, H., KÖKSAL, N., KURUTAŞ, E., ÇIRALIK, H., TOKUR, M., BOZKURT, S., KABAKCI, B., BALKAN, V. (2022). Protective effects of erythropoietin and n-acetylcysteine on methotrexate-induced lung injury in rats. Balkan Medical Journal, Cilt: 30 - Sayı: 1, 99–104. https://ajindex.com/articles/461543

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