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Journals / Balkan Medical Journal / 2017 / Cilt: 34 - Sayı: 4

Is the Diagnosis of Celiac Disease Possible Without Intestinal Biopsy?

Maha SHOMAF
Mohammad RASHİD
Dana FAYDİ
Ahmad HALAWA
Pages
313–317
Publication Date
2022-10-11
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

In the presence of high tissue transglutaminase levels, duodenal biopsy might not be always necessary for diagnosis, particularly in symptomatic patients.

📌 3 Key Takeaways

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Objective & Hypothesis:University Hospital archives between December 2014 and December 2015.
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Key Findings & Data:Results: Ninety-five cases with a positive titre for the antibody were included in this study, 73 (76.8%) of them were females and 22 cases (23.2%) were males.
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Conclusion & Impact:In the presence of high tissue transglutaminase levels, duodenal biopsy might not be always necessary for diagnosis, particularly in symptomatic patients.
🔬Design:Research Article
📍Scope:2014 Verileri
⚙️Variables:Domain Parameters

Abstract

University Hospital archives between December 2014 and December 2015. All the cases were classified according to the Marsh classification. Results: Ninety-five cases with a positive titre for the antibody were included in this study, 73 (76.8%) of them were females and 22 cases (23.2%) were males. The age of the patients ranged between 4 and 75 years with a mean age ± standard deviation of 32.3±14.7. The sensitivity was the highest in Marsh IIIC and lowest in Marsh IIIA (95% versus 68% respectively). The specificity was moderate (76%) for all subtypes of Marsh III. Conclusion: This study showed a positive correlation between the tissue transglutaminase titre and the degree of duodenal damage (Marsh IIIC) in patients with coeliac disease. In the presence of high tissue transglutaminase levels, duodenal biopsy might not be always necessary for diagnosis, particularly in symptomatic patients.

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Cite This Article

SHOMAF, M., RASHİD, M., FAYDİ, D., HALAWA, A. (2022). Is the Diagnosis of Celiac Disease Possible Without Intestinal Biopsy?. Balkan Medical Journal, Cilt: 34 - Sayı: 4, 313–317. https://ajindex.com/articles/461177

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