SavedAdd your journal

Journals / Balkan Medical Journal / 2017 / Cilt: 34 - Sayı: 1

Petroselinum Crispum is Effective in Reducing Stress-Induced Gastric Oxidative Damage

Burhan ATEŞ
Mukaddes EŞREFOĞLU
Elif TAŞLIDERE
Ayşin AKINCI
Pages
53–59
Publication Date
2022-10-11
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

The histopathologic damage score of the stress group (7.00±0.57) was higher than that of the control group (1.50±0.22) (p

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Background: Oxidative stress has been shown to play a principal role in the pathogenesis of stress-induced gastric injury.
📊
Key Findings & Data:Subjects were exposed to 72 hours of fasting and later immobilized and exposed to the cold at +4 degrees for 8 hours to create a severe stress condition.
💡
Conclusion & Impact:The histopathologic damage score of the stress group (7.00±0.57) was higher than that of the control group (1.50±0.22) (p
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Background: Oxidative stress has been shown to play a principal role in the pathogenesis of stress-induced gastric injury. Parsley (Petroselinum crispum) contains many antioxidants such as flavanoids, carotenoids and ascorbic acid. Aims: In this study, the histopathological and biochemical results of nutrition with a parsley-rich diet in terms of eliminating stress-induced oxidative gastric injury were evaluated. Study Design: Animal experimentation. Methods: Forty male Wistar albino rats were divided into five groups: control, stress, stress + standard diet, stress + parsley-added diet and stress + lansoprazole (LPZ) groups. Subjects were exposed to 72 hours of fasting and later immobilized and exposed to the cold at +4 degrees for 8 hours to create a severe stress condition. Samples from the animals’ stomachs were arranged for microscopic and biochemical examinations. Results: Gastric mucosal injury was obvious in rats exposed to stress. The histopathologic damage score of the stress group (7.00±0.57) was higher than that of the control group (1.50±0.22) (p

🔖

Cite This Article

ATEŞ, B., EŞREFOĞLU, M., TAŞLIDERE, E., AKINCI, A. (2022). Petroselinum Crispum is Effective in Reducing Stress-Induced Gastric Oxidative Damage. Balkan Medical Journal, Cilt: 34 - Sayı: 1, 53–59. https://ajindex.com/articles/461166

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (15)

  1. Bandyopadhyay D, Chattopadhyay A. Reactive oxygen species-induced gastric ulceration: protection by melatonin. Curr Med Chem 2006;13:1187-202
  2. Jia YT, Ma B, Wei W, Xu Y, Wang Y, Tang HT, et al. Sustained activation of nuclear factor-kappaB by reactive oxygen species is involved in the pathogenesis of stress-induced gastric damage in rats. Crit Care Med 2007;35:1582-91
  3. Jia YT, Wei W, Ma B, Xu Y, Liu WJ, Wang Y, et al. Activation of p38 MAPK by reactive oxygen species is essential in a rat model of stressinduced gastric mucosal injury. J Immunol 2007;179:7808-19
  4. Sahin E, Gümüşlü S. Stress-dependent induction of protein oxidation, lipid peroxidation and anti-oxidants in peripheral tissues of rats: comparison of three stress models (immobilization, cold and immobilization-cold). Clin Exp Pharmacol Physiol 2007;34:425-31
  5. Birben E, Sahiner UM, Sackesen C, Erzurum S, Kalayci O. Oxidative stress and antioxidant defense. World Allergy Organ J 2012;5:9-19
  6. Valko M, Rhodes CJ, Moncol J, Izakovic M, Mazur M. Free radicals, metals and antioxidants in oxidative stress-induced cancer. Chem Biol Interact 2006;160:1-40
  7. Gebicki JM, Nauser T, Domazou A, Steinmann D, Bounds PL, Koppenol WH. Reduction of protein radicals by GSH and ascorbate: potential biological significance. Amino Acids 2010;39:1131-7
  8. Seifried HE, Anderson DE, Fisher EI, Milner JA. A review of the interaction among dietary antioxidants and reactive oxygen species. J Nutr Biochem 2007;18:567-79
  9. Valko M, Leibfritz D, Moncol J, Cronin MT, Mazur M, Telser J. Free radicals and antioxidants in normal physiological functions and human diseases. Int J Biochem Cell Biol 2007;39:44-84
  10. Gremse DA. Lansoprazole: pharmocokinetics, pharmocodynamics and clinical uses. Expert Opin Pharmacother 2001;2:1663-70
  11. Demir A, Aydın A. A new drug in the treatment of peptic ulcer disease: Lansoprazole. Turkiye Klinikleri J Gastroenterohepatol 1998;9:1-6
  12. Becker JC, Grosser N, Waltke C, Schulz S, Erdmann K, Domschke W, et al. Beyond gastric acid reduction: proton pump inhibitors induce heme oxygenase-1 in gastric and endothelial cells. Biochem Biophys Res Commun 2006;345:1014-21
  13. Colin-Jones DG. Safety of lansoprasole. Aliment Pharmacol Ther 1993;7(Suppl 1):56-60
  14. Altunbaş M, Turel I. The lethal dose levels of volatile oil extract of Petroselinum crispum (Parsley) seeds and the investigation of antiinflammatory effect on laboratory animals. YYU Vet Fak Derg 2009;20:21- 5
  15. Fejes