Serotyping was performed and risk factorsof carriage were evaluated.Results: The overall carriage rate was 14%.
📌 3 Key Takeaways
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Objective & Hypothesis:Aims: To determine the prevalence of nasopharyngealcarriage of Streptococcus pneumoniae in healthy childrenaged 0-6 years who were vaccinated with pneumococcalconjugate vaccine.Methods: This cross-sectional study was conducted on150 healthy Turkish children between 1 month and 6years of age.
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Key Findings & Data:Serotyping was performed and risk factorsof carriage were evaluated.Results: The overall carriage rate was 14%.
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Conclusion & Impact:Overall,S. pneumoniae strains were considered as penicillinsusceptible and antimicrobial resistance was limited.Conclusion: We observed a low rate of pneumococcalcarriage in children after PCV13 implementationcompared with that of children receiving PCV7.Although it was reduced, vaccine serotype colonizationin PCV13-vaccinated children remains persistent.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters
Abstract
Aims: To determine the prevalence of nasopharyngealcarriage of Streptococcus pneumoniae in healthy childrenaged 0-6 years who were vaccinated with pneumococcalconjugate vaccine.Methods: This cross-sectional study was conducted on150 healthy Turkish children between 1 month and 6years of age. Serotyping was performed and risk factorsof carriage were evaluated.Results: The overall carriage rate was 14%. Vaccinetype serotypes were determined in 17 (12.6%) childrenwho received full-dose PCV13 vaccine. The highestcarriage rate was observed among children youngerthan 24 months (76.2%). In multivariate analysis,respiratory infection in recent months, age, attendanceat a day-care center and antibiotic usage were notstatistically significant risk factors for carriage. Overall,S. pneumoniae strains were considered as penicillinsusceptible and antimicrobial resistance was limited.Conclusion: We observed a low rate of pneumococcalcarriage in children after PCV13 implementationcompared with that of children receiving PCV7.Although it was reduced, vaccine serotype colonizationin PCV13-vaccinated children remains persistent.
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Cite This Article
GÖNÜLLÜ, N., TOKMAN, H. B., GÜR, E., ÇOKUĞRAŞ, H., TANER, Z., ARVAS, A. (2022). Pneumococcal Nasopharyngeal Carriage in Young Healthy Children After Pneumococcal Conjugate Vaccine in Turkey. Balkan Medical Journal, Cilt: 34 - Sayı: 4, 362–366. https://ajindex.com/articles/461160
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