Journals / Anadolu Kliniği Tıp Bilimleri Dergisi / 2020 / Sayı: Special Issue on COVID 19

COVID-19 Infections in Newborns

Yenidoğanlarda COVID-19 Enfeksiyonları

Pages
23–35
Publication Date
2020-03-20
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Since the infection is quite new and knowledge is constantly accumulating, following scientific developments is crucial.

📌 3 Key Takeaways

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Objective & Hypothesis:Novel type Coronavirus-19 is seen mainly in elderly people but it may be encountered in pregnant women and newborns also.
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Key Findings & Data:All the reported cases in pregnant women were in the 3rd trimestr and only 1% of them developed severe disease.
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Conclusion & Impact:Since the infection is quite new and knowledge is constantly accumulating, following scientific developments is crucial.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Yenidoğan · COVID-19 · vertikal geçiş

Abstract

Novel type Coronavirus-19 is seen mainly in elderly people but it may be encountered in pregnant women and newborns also. The information about its clinical features, laboratory findings and prognosis in children and newborns is scarce. Since the immunological systems of the newborns have not developed completely, it may be considered that their risks are larger. All the reported cases in pregnant women were in the 3rd trimestr and only 1% of them developed severe disease. There is no data yet on the materno-fetal transmission of the disease. Case reports of newborns are similar to those of adults. Definitive diagnosis can be made by a history of contact with a proven case, fever, pneumonia and gastrointestinal disorder. Lymphopenia, liver and renal function disorders may be seen. Suspected or proven cases of newborns should be isolated in the neonatal intensive care unit for at least 14 days with standart and droplet isolation precautions. If needed, the transport of the neonate should be performed in a transport incubator with isolation precautions. The incubator and the ambulance should be disenfected before and after the transport. There is no specific treatment for the disease, but hemodynamic stabilization of the infant, respiratory management and other daily care are essential. Some drugs are under investigation. Routine antibiotics are not recommended. No deaths have been reported in infected cases. Possible hyperbilirubinemia of the infant should be managed appropiately. Families and healthcare staff should receive pyschological support. Since the infection is quite new and knowledge is constantly accumulating, following scientific developments is crucial.

Özet

Yeni tip Coronavirüs-19, genellikle yaşlı bireylerde görülmesine rağmen gebelerde ve yenidoğan bebeklerde de görülebilmektedir. Virüsün çocuklarda ve yenidoğanlardaki klinik özellikleri, laboratuvar bulguları ve prognozu hakkında yeteri kadar bilgi yoktur. Yenidoğanların immün sistemleri yeteri kadar gelişmemiş olduğundan daha büyük risk altında oldukları düşünülebilir. Şimdiye kadar bildirilen gebelerin hemen hepsi 3. trimestrde enfekte olmuşlardır. Bu kadınların ancak % 1’inde kritik hastalık gelişmiştir. Ancak şimdiye kadar materno-fetal vertikal geçişi kanıtlayabilecek bir veri elde edilememiştir. Yenidoğanlardaki vaka tanımları erişkinlerdekine benzerdir. Kesin tanılı hasta biriyle temasın yanı sıra, ateş, solunum yolu bulguları, pnömoni ve gastrointestinal bulgular gözlenebilir. Hastalarda lenfopeni bulunabileceği gibi karaciğer ve böbrek fonksiyon bozukluklarına da rastlanabilir. Şüpheli veya kesin tanılı yenidoğanların yenidoğan yoğun bakım ünitesinde 14 gün süreyle izole edilmeleri ve standart ve damlacık enfeksiyonu temas önlemlerinin alınması gerekir. Yenidoğanların transportu gerekirse, küvöz içinde, gerekli önlemler alınarak transport edilmeli, transport öncesi ve sonrasında ambulans dahil tüm ekipman dezenfekte edilmelidir. Hastalığın kesin bir tedavisi olmadığı için yenidoğanın hemodinamik stabilitesinin sağlanması, solunum desteği verilmesi ve diğer rutin bakımlarının yapılması yerinde olur. Rutin antibiyotik kullanımına gerek yoktur. Şimdiye kadar enfekte olan yenidoğanlar arasında ölüm bildirilmemiştir. Taburcu edilen bebeklerde muhtemel sarılık gelişimine karşı da önlem alınmalıdır. Ailelere de psikolojik ve sosyal destek sağlanması yerinde olur. Hastalık hakkındaki bilgiler az olduğu için yeni gelişmeler takip edilmelidir.

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Cite This Article

OVALI, F. (2020). COVID-19 Infections in Newborns. Anadolu Kliniği Tıp Bilimleri Dergisi, Sayı: Special Issue on COVID 19, 23–35. https://ajindex.com/articles/459324

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References (5)

  1. Wu Z, McGoogan JM. Characteristics of and important lessons from the coronvirus disease 2019 (COVID-19) outbreak in China: summary of a report of 72314 cases from the Chinese center for disease control and prevention. JAMA 2020 (epub ahead of print
  2. Lu Q, Shi Y. Coronavirus disease (COVID-19) and neonate: what the neonatologist need to know. J Med Virol 2020; 1-4 3) Hoffmann M, Kleine-Weber H, Krügir N, Müller M, Drosten C, Pöhlmann S. The novel coronavirus 2019 (2019-nCov) uses the SARS-coronavirus receptor 2 ACE2 and the cellular protease TMPRSS2 for entry into target cells. BioRxiv 2020. https://doi.org/10.1101/2020. 01.31.929042 4) Zhang Q, Cong M, Wang N et al. Association of angiotensin converting enzyme 2 gene polymorphism and enzymatic activity with essential hypertension in different gender: a case-control study. Medicine 2018; 97(42): e12917 5) Zhao Y, Zhano Z, Wang Y, Zohu Y, Ma Y, Zuo W. Single cell RNA exepression profiling of ACE2 the putative receptor of Wuhan 2019nCov. bioRxiv. 2020.
  3. Huynh J, Li S, Yount B, et al. Evidence supporting a zoonotic origin of human coronavirus strain NL63. J Virol. 2012;86:12816–12825
  4. Vijgen L, Keyaerts E, Moes E et al. Complete genomic sequence of human coronavirus OC43: molecular clock analysis suggests a relatively recent zoonotic coronavirus transmission event. J Virol 2005; 79: 1595-1604 8) Shi Z, Hu Z. A review of studies on animal reservoirs of the SARS coronavirus. Virus Res 2008; 133: 74-87 9) Chan JF, Yuan S, Kok KH et al. A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person to person transmission: a study of a family cluster. Lancet 2020; 395: 514-523 10) Wu JT, Leung K, Leung GM. Nowcasting and forecasting the potential domestic and intirnational spread of the 2019-nCoV outbreak originating in Wuhan, China: a modelling study. Lancet 2020; 395: 689-697 11) Chowel G, Abdirizak F, Lee S et al. Transmission charcteristics of MERS and SARS in the healthcare setting: a comparative study. BMC Med 2015; 13: 210 12) Leung GM, Hedley AJ, Ho LM et al. The epidemiology of severe acute respiratory syndrome in the 2003 Hong Kong epidemic: an analysis of all 1755 patients. Ann Intern Med 2004; 141: 662-673 13)
  5. Vabret A, Mourez T, Gouarin S et al. An outbreak of coronavirus OC43 respiratory infection in Normandy, France. Clin Infect Dis 2003; 36: 985-989 15) Gaunt