In this study, we aimed to evaluate if there was a relationship between MHR and the risk of presence of symptomatic plaque in patients with intermediate carotid artery stenosis.
📌 3 Key Takeaways
🎯
Objective & Hypothesis:Aim: Monocyte to high-density lipoprotein cholesterol (HDL-C) ratio (MHR) is a new and easily measurable marker positively associated with inflammation.
📊
Key Findings & Data:Aim: Monocyte to high-density lipoprotein cholesterol (HDL-C) ratio (MHR) is a new and easily measurable marker positively associated with inflammation.
💡
Conclusion & Impact:In this study, we aimed to evaluate if there was a relationship between MHR and the risk of presence of symptomatic plaque in patients with intermediate carotid artery stenosis.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Monosit/HDL-K oranı · karotis arter · semptomatik plak
Abstract
Aim: Monocyte to high-density lipoprotein cholesterol (HDL-C) ratio (MHR) is a new and easily measurable marker positively associated with inflammation. In this study, we aimed to evaluate if there was a relationship between MHR and the risk of presence of symptomatic plaque in patients with intermediate carotid artery stenosis.
Özet
Amaç: Monosit/yüksek yoğunluklu lipoprotein kolesterol oranı (MHR), inflamasyon ile pozitif ilişkili yeni ve kolayca ölçülebilen bir belirteçtir. Bu çalışmada orta düzey karotis arter darlığı olan hastalarda MHR ile semptomatik plak varlığı arasında bir ilişki olup olmadığını değerlendirmeyi amaçladık.
ENHOŞ, A., KARAÇÖP, E. (2021). Is Elevated Monocyte to High-Density Lipoprotein Ratio A Predictor of Symptomatic Plaque in Patients With İntermediate Carotid Artery Stenosis?. Anadolu Kliniği Tıp Bilimleri Dergisi, Cilt: 26 - Sayı: 1, 17–22. https://ajindex.com/articles/459283
Gorelick PB, Wong KS, Bae HJ, et al. Large artery intracranial occlusive disease: a large worldwide burden but a relatively neglected frontier. Stroke. 2008;39:2396-2399.
Hansson GK, Libby P, Schonbeck U, et al. Innate and adaptive immunity in the pathogenesis of atherosclerosis. Circ Res. 2002;91:281–91. Libby P. Inflammation in atherosclerosis. Arterioscler Thromb Vasc Biol. 2012;32:2045-51.
Hristov M, Heine GH. Monocyte subsets in atherosclerosis. Hamostaseologie. 2015;35(2):105–12.
Moore KJ, Sheedy FJ, Fisher EA. Macrophages in atherosclerosis: a dynamic balance. Nat Rev Immunol. 2013;13:709–21.
Chapman CM, Beilby JP, McQuillan BM, et al. Monocyte count, but not c-reactive protein or interleukin-6, is an independent risk marker for subclinical carotid atherosclerosis. Stroke. 2004;35:1619–24.
Matsumura T, Taketa K, Motoshima H, et al. Association between circulating leukocyte subtype counts and carotid intima-media thickness in Japanese subjects with type 2 diabetes. Cardiovasc Diabetol. 2013;12:177. Canpolat U, Çetin EH, Cetin S, et al. Association of monocyte-to-HDL cholesterol ratio with slow coronary flow is linked to systemic inflammation. Clin Appl Thromb Hemost. 2016;22(5):476-82.
Liapis CD, Bell PR, Mikhailidis D, et al. ESVS guidelines. Invasive treatment for carotid stenosis: indications, techniques. Eur J Vasc Endovasc Surg 2009;37(4 Suppl):1-19.
Brott TG, Halperin JL, Abbara S, et al. ASA / ACCF /AHA / AANN / AANS / ACR / ASNR / CNS / SAIP / SCAI / SIR / SNIS / SVM / SVS guideline on the management of patients with extracranial carotid and vertebral artery disease: executive summary: a report. J Am Coll Cardiol. 2011;57:1002-1044.
Mathers CD, Boerma T, Ma Fat D. Global and regional causes of death. Br Med Bull. 2009;92:7e32. Cybulsky MI, Gimbrone JrMA. Endothelial expression of a mononuclear leukocyte adhesion molecule during atherogenesis. Science. 1991;251:788e91. Ghattas A, Griffiths HR, Devitt A, et al. Monocytes in coronary artery disease and atherosclerosis: where are we now? J Am Coll Cardiol. 2013;62(17):1541-1551.
Murphy AJ, Chin-Dusting JP, Sviridov D, et al. The anti inflammatory effects of high density lipoproteins. Curr Med Chem. 2009;16(6):667-675.Murphy AJ, Woollard KJ. High-density lipoprotein: a potent inhibitor of inflammation. Clin Exp Pharmacol Physiol. 2010;37(7):710-718.
Yvan-Charvet L, Pagler T, Gautier EL, et al. ATP-binding cassette transporters and HDL suppress hematopoietic stem cell proliferation. Science. 2010