Journals / Bağcılar Tıp Bülteni / 2021 / Cilt: 6 - Sayı: 1

Contribution of Endorectal Ultrasound, Magnetic Resonance Imaging and Positron Emission Tomography to Operation Strategy in Rectal Cancer

Endorektal Ultrasonografi, Manyetik Rezonans Görüntüleme ve Pozitron Emisyon Tomografisinin Rektum Kanserinde Ameliyat Stratejisine Katkıları

Pages
61–65
Publication Date
2022-10-12
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Conclusion: Efficacy of routine use of PET-CT on staging, evaluation of T, N and extramesorectal spread could not be shown.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Objective: Colorectal cancer is the most common type of cancer in the gastrointestinal tract.
📊
Key Findings & Data:Method: In this study, between October 2010-April 2012, 30 patients who were diagnosed as rectal cancer clinically and histopathologically were evaluated with ERUS, MRI and PET-CT preoperatively and results were compared with histopathologic findings.Results: Between October 2010-April 2012, 30 patients who were diagnosed as rectal cancer with biopsy in Bezmialem University Medical Faculty Hospital General Surgery Department were included in this study [20 male (66.6%), 10 female (33.3%) and their ages are 38-75 years old, 21 of them received neoadjuvant treatment and 9 of them did not received].
💡
Conclusion & Impact:Conclusion: Efficacy of routine use of PET-CT on staging, evaluation of T, N and extramesorectal spread could not be shown.
🔬Design:Research Article
📍Scope:2010 Verileri
⚙️Variables:Domain Parameters

Abstract

Objective: Colorectal cancer is the most common type of cancer in the gastrointestinal tract. Preoperative staging is important for applying appropriate treatment modalities. The role of endorectal ultrasonography (ERUS), magnetic resonance imaging (MRI) and positron emission-computed tomography (PET-CT) in rectal cancer patients was evaluated. Method: In this study, between October 2010-April 2012, 30 patients who were diagnosed as rectal cancer clinically and histopathologically were evaluated with ERUS, MRI and PET-CT preoperatively and results were compared with histopathologic findings.Results: Between October 2010-April 2012, 30 patients who were diagnosed as rectal cancer with biopsy in Bezmialem University Medical Faculty Hospital General Surgery Department were included in this study [20 male (66.6%), 10 female (33.3%) and their ages are 38-75 years old, 21 of them received neoadjuvant treatment and 9 of them did not received]. All patients were evaluated with MRI, ERUS and PET-CT preoperatively. Rectal cancer patients who are primarily operated from rectal adenocarcinoma were included in this study. For T staging, preoperative MRI, ERUS and PET-CT staged 9 (31%), 12 (41%) and 12 (40%) of 30 patients accurately, respectively. For N staging, preoperative MRI, ERUS and PET-CT staged 15 (51%), 16 (55.1%) and 17 (56.6%) of 30 patients accurately, respectively. In comparison to other modalities, PET-CT did not yield a significant difference in staging and did not change operation strategy. PET-CT detected distant metastasis in 3 patients. One of them was liver and two of them were lung metastasis. Biopsies from mass predicted as lung metastasis did not result as metastasis. PET-CT has high rates of false positivity to detect distant metastasis. In statistical analysis, significant p-values for evaluation could not be obtained. Conclusion: Efficacy of routine use of PET-CT on staging, evaluation of T, N and extramesorectal spread could not be shown.

Özet

Amaç: Gastrointestinal sistemin en sık görülen kanserleri kolorektal kanserlerdir.Özelliklerektumkanserlihastalardaoperasyonöncesievreleme büyük önem taşımaktadır. Bunun sebebi ise evrelemeye göre tedavi yönetimindeki değişik olanakların hasta için tercih edilebilmesidir. Evrelemehastaiçinuyguntedaviyönetiminiplanlamayayardımcıolmaktadır. Rektum kanserli hastaların endorektal ultrasonografi (ERUS), manyetik rezonans görüntüleme (MRG) ve pozitron emisyonu-bilgisayarlı tomografi (PET-BT) ile yapılan değerlendirilmelerinin ameliyat stratejisine etkileri araştırıldı. Yöntem: Bu çalışmada; klinik ve histopatolojik olarak Ekim 2010-Nisan 2012 arasında rektum kanseri tanısı almış 30 olgu preoperatif olarak ERUS, MRG ve PET-BT ile değerlendirilmiş, sonuçlar histopatolojik bulgularla karşılaştırılmıştır. Bulgular:Ekim2010-Nisan2012tarihleriarasındaBezmialemÜniversitesi Tıp Fakültesi Hastanesi Genel Cerrahi Anabilim Dalında biyopsi ile rektum kanseri tanısı alan 30 hasta çalışmaya alınmıştır. Yirmi hasta erkek (%66,6), 10 hasta kadın (%33,3) idi. Hastaların yaşları 38 ile 78 arasındaydı, 21 hasta neoadjuvan tedavi gördü. Dokuz hasta neoadjuvan tedavi görmedi. Hastaların tümüne preoperatif MRG, PET-BT ve ERUS yapılmıştır. Çalışmaya opere edilen primer rektum adenokanserli hastalar dahil edildi. T evresini değerlendirmede MRG, ERUS ve PET-BT 30 hastadan sırasıyla 9 (%31), 12 (%41) ve 12 (%40) hastada doğru evreledi. N evresini değerlendirmede MRG, ERUS ve PET-BT 30 hastadan sırasıyla 15 (%51), 16 (%55,1) ve 17 (%56,6) hastada doğru evreledi. PET-BT ’nin diğer görüntüleme yöntemleri ile karşılaştırıldığında evrelemede anlamlı bir farklılık oluşturmadığı ve ameliyat stratejisini değiştirmediği görülmüştür. PET-BT ile üç hastada uzak metastaz saptandı. Bunlardan biri karaciğer, ikisiakciğermetastazıidi.Akciğermetastazıdüşünülenkitlelerdenalınan biyopsilerde metastaz saptanmadı. PET-BT ’nin uzak metastazı saptamada yüksek yanlış pozitiflik oranı olduğu görülmüştür. İstatiksel analizde değerlendirme sonucu için anlamlı p-değerleri saptanmamıştır. Sonuç: PET-BT ’nin rektum kanseri evrelemesinde T, N ve ekstramezorektal yayılımdeğerlendirilmesinderutinolarakkullanılmasınınfaydasıgösterilememiştir.

🔖

Cite This Article

ÇAKIR, C., FIRAT, Y. D., BEKTAŞOĞLU, H. K., ÇİPE, G., ARICI, S., MÜSLÜMANOĞLU, M. (2022). Contribution of Endorectal Ultrasound, Magnetic Resonance Imaging and Positron Emission Tomography to Operation Strategy in Rectal Cancer. Bağcılar Tıp Bülteni, Cilt: 6 - Sayı: 1, 61–65. https://ajindex.com/articles/458882

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (15)

  1. Anne BB, Clive A. Colorectal cancer. Clinical review. BMJ 2007;335(7622):715-718
  2. Harrison JC, Dean PJ, el Zeky F, Vander ZR. From Dukes through Jass: pathological prognostic indicators in rectal cancer. Hum Pathol 1994;25(5):498-505
  3. Wolmark N, Fisher B, Wieand HS. The prognostic value of the modifications of the Dukes’ C class of colorectal cancer. Ann Surg 1986;203(2):115-122
  4. Dworak O, Keilholz L, Hoffmann A. Pathological features of rectal cancer after preoperative radiochemotherapy. Int J Colorectal Dis 1997;12(1):19-23
  5. Wanebo HJ, Koness RJ, Vezeridis MP, Cohen SI, Wrobleski DE. Pelvic resection of recurrent rectal cancer. Ann Surg 1994;220(4):586-597
  6. Gunderson LL, Sargent DJ, Tepper JE, O’Connell MJ, Allmer C, Smalley SR, et al. Impact of T and N substage on survival and disease relapse in adjuvant rectal cancer: a pooled analysis. Int J Radiat Oncol Biol Phys 2002;54(2):386-396
  7. Akasu T, Sunouchi K, Sawada T, Tsioulias GJ, Muto T, Morioka Y. Preoperative staging of rectal carcinoma: prospective comparison of transrectal ultrasonography and computed tomography. Gastroenterology 1990;98:268 (Abstract)
  8. Beynon J, Mortensen NJ, Foy DM, Channer JL, Virjee J, Goddard P. Preoperative assessment of local invasion in rectal cancer: digital examination, endoluminal sonography or computed tomography. Br J Surg 1986;73(12):1015-1017
  9. Garcia-Aguilar J, Pollack J, Lee SH, Hernandez de Anda E, Mellgren A, Wong WD, et al. Accuracy of endorectal ultrasonography in preoperative staging of rectal tumors. Dis Colon Rectum 2002;45(1):10-15
  10. Gore Richard M. The Radiologic Clinics of North America 1997;35(2)404-405
  11. Fleshman JW, Myerson RJ, Fry RD, Kodner IJ. Accuracy of transrectal ultrasound in predicting pathologic stages of rectal cancer before and after preoperative radiation therapy. Dis Colon Rectum 1992;35(9):823-829
  12. Romano G, de Rosa P, Vallone G, Rotondo A, Grassi R, Santangelo ML. Intrarectal ultrasound and computed tomography in the pre- and postoperative assessment of patients with rectal cancer. Br J Surg 1985;72(Suppl):S117-119
  13. Isbert C, Germer CT. Impact of endoscopy and endosonography on local staging of rectal carcinoma. Chirurg 2012;83(5):430-438
  14. Ptok H, Gastinger I, Lippert H. Local diagnostics for rectal cancer. What is realistic? Chirurg 2012;83(5):448-451
  15. Decanini-Terán CO, González-Acosta J, Obregón-Méndez J, Vega-de Jesús M. Rectal cancer: diagnosis, screening and treatment. Cir Cir 2011;79