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Journals / Bağcılar Tıp Bülteni / 2022 / Cilt: 7 - Sayı: 2

Could Asymmetric Dimethylarginine Have a Role in COVID-19 Cases?

Asimetrik Dimetilarjininin COVID-19’daki Rolü

Müfide Arzu ÖZKARAFAKILI
Mustafa İlteriş BARDAKÇI
Zeynep Mine YALÇINKAYA
Işık Kibar AKILLI
Pages
102–109
Publication Date
2022-10-12
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

ADMA had an inverse correlation with RDW (r=-0.391, p

📌 3 Key Takeaways

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Objective & Hypothesis:Objective: Coronavirus disease-2019 (COVID-19) is a disease with respiratory involvement and the virus-induced endothelial dysfunction is pronounced in the clinical course.
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Key Findings & Data:In COVID-19 patients, to analyze the laboratory findings and the associations may help to better understand the pathophysiology of this disease.
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Conclusion & Impact:ADMA had an inverse correlation with RDW (r=-0.391, p
🔬Design:Research Article
📍Scope:2019 Verileri
⚙️Variables:Domain Parameters

Abstract

Objective: Coronavirus disease-2019 (COVID-19) is a disease with respiratory involvement and the virus-induced endothelial dysfunction is pronounced in the clinical course. In COVID-19 patients, to analyze the laboratory findings and the associations may help to better understand the pathophysiology of this disease. Method: We analyzed the laboratory markers including white blood cell, platelet, mean platelet volume, red cell distribution width (RDW), lactate dehydrogenase, procalcitonin, arterial blood gas values and asymmetric dimethylarginine (ADMA) levels of 83 hospitalized COVID-19 patients with pneumonia. Thirty healthy individuals were enrolled as a control group and their laboratory findings were compared. Results: No significant difference of ADMA levels (median value 225.6 μg/L vs 225.6 μg/L) was noted between COVID-19 patients and the control group (p=0.771). ADMA had an inverse correlation with RDW (r=-0.391, p

Özet

Amaç: Koronavirüs hastalığı-2019 (COVID-19) solunum tutulumu olan bir hastalıktır ve virüs kaynaklı endotelyal disfonksiyon klinik seyirde belirgindir. COVID-19 hastalarında laboratuvar bulgularının ve birlikteliklerin analiz edilmesi bu hastalığın patofizyolojisinin daha iyi anlaşılmasına yardımcı olabilir. Yöntem: Hastaneye yatırılan 83 pnömonili COVID-19 hastasının beyaz kan hücresi, trombosit, ortalama trombosit hacmi, kırmızı hücre dağıtım genişliği (RDW), laktat dehidrogenaz, prokalsitonin, arter kan gazı değerleri ve asimetrik dimetilarginin (ADMA) düzeylerini içeren laboratuvar belirteçleri incelendi. Kontrol grubu olarak 30 sağlıklı kişi alındı ve laboratuvar bulguları karşılaştırıldı. Bulgular: COVID-19 hastaları ve kontrol grubu arasında ADMA seviyelerinde (ortanca değer 225,6 μg/L’ye karşı 225,6 μg/L’ye karşı) anlamlı bir fark görülmedi (p=0,771). ADMA, RDW ile ters bir korelasyona sahipti (r=-0,391, p

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Cite This Article

ÖZKARAFAKILI, M. A., BARDAKÇI, M. İ., YALÇINKAYA, Z. M., AKILLI, I. K. (2022). Could Asymmetric Dimethylarginine Have a Role in COVID-19 Cases?. Bağcılar Tıp Bülteni, Cilt: 7 - Sayı: 2, 102–109. https://ajindex.com/articles/458869

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