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Journals / Avrupa Bilim ve Teknoloji Dergisi / 2019 / Cilt: 0 - Sayı: 16

Akkermansia muciniphila: Could It Be a New Alternative to Prevention from Obesity and Diabetes?

Akkermansia muciniphila: Obezite ve Diyabetten Korunmada Yeni Bir Alternatif Olabilir mi?

Havva POLAT
Lütfiye EKİCİ
Pages
533–543
Publication Date
2022-10-11
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

In addition, it is aimed to compile the literature data on mechanism of the action of Akkermansia muciniphila on obesity and diabetes.

📌 3 Key Takeaways

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Objective & Hypothesis:Akkermansia muciniphila is one of the members of the gastrointestinal microbiota which has been recently isolated from the human fecal sample and attracted attention.
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Key Findings & Data:Akkermansia is also effective by increasing the secretion of GLP-1 which stimulates insulin secretion.
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Conclusion & Impact:In addition, it is aimed to compile the literature data on mechanism of the action of Akkermansia muciniphila on obesity and diabetes.
🔬Design:Review & Systematic Survey
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Akkermansia muciniphila is one of the members of the gastrointestinal microbiota which has been recently isolated from the human fecal sample and attracted attention. The results obtained from scientific studies suggest that Akkermansia muciniphila may be an alternative solution to today's important health problems such as diabetes and obesity. This effect of Akkermansia result from the reduction of metabolic endotoxemia by modulating the mucus thickness and intestinal barrier integrity positively by the ability to degrade the mucin. Akkermansia is also effective by increasing the secretion of GLP-1 which stimulates insulin secretion. Nutritional habits of people, alcohol consumption, metmorphine and antibiotic treatments are among the factors that directly affect the density of Akkermansia in the intestine. It was determined that the polyphenol, probiotic and prebiotic contents of the foods included in the diets of individuals had effects on the number of Akkermansia. The aim of this review is to evaluate the factors affecting the importance and activity of Akkermansia muciniphila in intestinal flora. In addition, it is aimed to compile the literature data on mechanism of the action of Akkermansia muciniphila on obesity and diabetes.

Özet

Akkermansia muciniphila, insan fekal örneğinden yakın tarihte izole edilen ve dikkatleri üzerine çeken gastrointestinal mikrobiyotaüyelerinden biridir. Bilimsel çalışmalardan elde edilen sonuçlar, Akkermansia muciniphila’ nın diyabet ve obezite gibi günümüzünönemli sağlık sorunlarına karşı alternatif bir çözüm olabileceğini düşündürmektedir. Akkermansia’ nın bu etkisi, müsini degradeedebilme yeteneği sayesinde mukus kalınlığını ve bağırsak bariyer bütünlüğünü pozitif şekilde modüle ederek metabolik endotoksemiyiazaltmasından kaynaklanmaktadır. Akkermansia insülin salgılanmasını uyaran GLP-1 hormonunu sekresyonunu arttırarak da etkiliolmaktadır. İnsanların beslenme alışkanlıkları, alkol tüketimi, metmorfin ve antibiyotik tedavileri bağırsaktaki Akkermansiayoğunluğunu birebir etkileyen faktörler arasındadır. Bireylerin diyetlerinde yer alan gıdaların polifenol, probiyotik ve prebiyotikiçeriklerinin de Akkermansia sayısı üzerine etkilerinin olduğu belirlenmiştir. Bu derlemenin amacı, Akkermansia muciniphila’ nınbağırsak florasındaki önemi ve aktivitesi üzerine etkili faktörlerin değerlendirilmesidir. Ayrıca, Akkermansia muciniphila’ nın obeziteve diyabet üzerine etki mekanizması konusundaki literatür verilerinin derlenmesi hedeflenmiştir.

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Cite This Article

POLAT, H., EKİCİ, L. (2022). Akkermansia muciniphila: Could It Be a New Alternative to Prevention from Obesity and Diabetes?. Avrupa Bilim ve Teknoloji Dergisi, Cilt: 0 - Sayı: 16, 533–543. https://ajindex.com/articles/458517

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