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Journals / Avrupa Bilim ve Teknoloji Dergisi / 2020 / Cilt: 0 - Sayı: 20

Determination Of Ciprofloxacin In Pharmaceutical Dosage, HumanSerum and Urine, Using Molecularly Imprinted Polymer ModifiedElectrode By Voltammetry

Farmasötik Dozaj, İnsan Serumu ve İdrarındaki Siprofloksasinin Moleküler Baskılı Polipirol Modifiye Elektrot Kullanılarak Voltametrik Tayini

Gizem YILDIRIM BAŞTEMUR
Sabriye PERÇİN ÖZKORUCUKLU
Berrin GÜRLER AKYÜZ
Esengül KIR
Pages
859–865
Publication Date
2022-10-11
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Recommended method was successfully employed for determination of CF in pharmaceutical, human serumand urine.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Molecularly imprinted polymer based working electrode was prepared for the determination of ciprofloxacin (CF).
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Key Findings & Data:Electrochemicalbehavior of CF was investigated by differential pulse voltammetric (DPV) method in the range of 10-60% (v/v) acetonitrile (MeCN)- H2O binary mixture at the pH between 3-7 prepared Britton-Robinson (BR) buffers.
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Conclusion & Impact:Recommended method was successfully employed for determination of CF in pharmaceutical, human serumand urine.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Molecularly imprinted polymer based working electrode was prepared for the determination of ciprofloxacin (CF). Electrochemicalbehavior of CF was investigated by differential pulse voltammetric (DPV) method in the range of 10-60% (v/v) acetonitrile (MeCN)- H2O binary mixture at the pH between 3-7 prepared Britton-Robinson (BR) buffers. Voltammetric analyzes were performed withmolecularly imprinted (MIP) and non-imprinted (NIP) modified electrodes. The influence of the electropolymerization cycles,solution pH, and MeCN-H2O ratio, on the performance of both electrodes were evaluated and optimized. Detection limit was obtainedas 1.12×$10^{-5}$ M (S/N=3). Recommended method was successfully employed for determination of CF in pharmaceutical, human serumand urine.

Özet

Siprofloksasin tayini için moleküler baskılı polimer bazlı çalışma elektrodu hazırlanmıştır. Siprofloksasinin elektrokimyasal davranışı% 10-60 (v/v) asetonitril-su ikili karışımında ve pH 3-7 aralığında hazırlanan Britton-Robinson (BR) tamponu kullanılarakdiferansiyel puls voltametrisi (DPV) yöntemiyle incelenmiştir. Voltametrik analizler moleküler baskılı (MIP) ve baskısız (NIP)modifiye elektrotlar ile gerçekleştirilmiştir. Elektropolimerizasyon döngü sayısı, çözelti pH'sı ve asetonitril-su oranının her iki tipelektrodun performansı üzerindeki etkisi araştırılmış ve optimize edilmiştir. Dedeksiyon limiti 1.12×$10^{-5}$ M (S/N = 3) olarakbulunmuştur. Önerilen yöntem farmasötik dozajda, insan kanı ve idrarındaki siprofloksasinin tayini için başarıyla uygulanmıştır.

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Cite This Article

BAŞTEMUR, G. Y., ÖZKORUCUKLU, S. P., AKYÜZ, B. G., KIR, E. (2022). Determination Of Ciprofloxacin In Pharmaceutical Dosage, HumanSerum and Urine, Using Molecularly Imprinted Polymer ModifiedElectrode By Voltammetry. Avrupa Bilim ve Teknoloji Dergisi, Cilt: 0 - Sayı: 20, 859–865. https://ajindex.com/articles/457845

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