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Journals / Abant Tıp Dergisi / 2021 / Cilt: 10 - Sayı: 1

New Hematological Indices as Simple and Practical Severity Markers of Obstructive Sleep Apnea Syndrome: Mean Platelet Volume/High Density Lipoprotein and Red-Cell Diameter Width/High Density Lipoprotein Ratio

Obstrüktif Uyku Apne Sendromu Şiddetini Gösteren Kolay ve Pratik Yeni Belirteçler: Ortalama Trombosit Hacmi/Yüksek Dansiteli Lipoprotein ve Eritrosit Dağılım Hacmi/Yüksek Dansiteli Lipoprotein

Recep ALANLI
Murat Bülent KÜÇÜKAY
Serkan YALÇIN
Pages
32–39
Publication Date
2021-04-30
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Conclusion: MPV/HDL and RDW/HDL ratios may be used to predict severity of OSAS, as novel markers.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Purpose: The aim of this study is to analyze correlation between novel markers mean platelet volume (MPV)/high density lipoprotein (HDL) and erythrocyte diameter width (RDW)/HDL ratios, and existence and severity of OSAS.
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Key Findings & Data:Methods: Patients who had polysomnography test between January 2017 to March 2020 were evaluated and 510 patients whose complete records could be obtained were enrolled.
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Conclusion & Impact:Conclusion: MPV/HDL and RDW/HDL ratios may be used to predict severity of OSAS, as novel markers.
🔬Design:Research Article
📍Scope:2017 Verileri
⚙️Variables:obstrüktif uyku apne sendromu · ortalama trombosit hacmi · eritrosit dağılım hacmi

Abstract

Purpose: The aim of this study is to analyze correlation between novel markers mean platelet volume (MPV)/high density lipoprotein (HDL) and erythrocyte diameter width (RDW)/HDL ratios, and existence and severity of OSAS. Methods: Patients who had polysomnography test between January 2017 to March 2020 were evaluated and 510 patients whose complete records could be obtained were enrolled. Participants who were using drugs affecting thyroid and sleep order were excluded. Participants were compared for age, gender, monocyte, neutrophil, lymphocyte and platelet counts, mean corpuscular volume (MCV), MPV, RDW, HDL, monocyte/HDL, MPV/HDL and RDW/HDL ratios in OSAS group and control group. Results: There was a significant correlation between severity of OSAS and age, HDL, RDW, MPV/HDL and RDW/HDL ratios. Compared to control group, there were significant differences in age (p=0.005) and HDL (p=0.001) in OSAS group. Conclusion: MPV/HDL and RDW/HDL ratios may be used to predict severity of OSAS, as novel markers.

Özet

Amaç: Bu çalışmanın amacı, yeni birer belirteç olan; ortalama trombosit hacmi (MPV)/yüksek dansiteli lipoprotein (HDL) ve eritrosit dağılım hacmi (RDW)/HDL oranları ile obstrüktif uyku apne sendromu (OUAS) varlığı ve şiddeti arasındaki ilişkiyi değerlendirmektir. Gereç ve Yöntem: Ocak 2017 ile Mart 2020 arasında polisomnografi yapılan ve sonuçlarına eksiksiz ulaşılabilen 510 hasta ile çalışma yapılmıştır. Tiroid hormon düzeylerini ve uyku düzenini etkileyebilecek ilaç kullanan hastalar çalışma dışı tutulmuştur. OUAS olan ve OUAS olmayan hastaların; yaş, cinsiyet, nötrofil, lenfosit ve trombosit sayısı, ortalama eritrosit hacmi (MCV), MPV, RDW, HDL, monosit/HDL, MPV/HDL ve RDW/HDL oranları karşılaştırıldı. Bulgular: OUAS şiddetiyle; yaş, HDL, RDW, MPV/HDL ve RDW/HDL oranı arasında anlamlı bir ilişki saptanmıştır. OUAS olanlarda kontrol grubuna göre (OUAS olmayan); yaş ve cinsiyet arasında anlamlı bir ilişki saptanmıştır. Sonuç: MPV/HDL ve RDW/HDL oranları, OUAS şiddetini göstermek için yeni birer belirteç olarak kullanılabilir.

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Cite This Article

ALANLI, R., KÜÇÜKAY, M. B., YALÇIN, S. (2021). New Hematological Indices as Simple and Practical Severity Markers of Obstructive Sleep Apnea Syndrome: Mean Platelet Volume/High Density Lipoprotein and Red-Cell Diameter Width/High Density Lipoprotein Ratio. Abant Tıp Dergisi, Cilt: 10 - Sayı: 1, 32–39. https://ajindex.com/articles/448703

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References (12)

  1. Attal P, Chanson P. (2010). Endocrine Aspects of Obstructive Sleep Apnea. The Journal of Clinical Endocrinology & Metabolism, 95(2), 483–495. doi:10.1210/jc.2009-1912
  2. Thorpy M. (2017). International Classification of Sleep Disorders. Sleep Disorders Medicine, 475–484. doi:10.1007/978-1-4939-6578-6_27
  3. Xie JY1, Liu WX, Ji L, Chen Z, Gao JM, Chen W, Chen GF, Zhu Q. Relationship between inflammatory factors and arrhythmia and heart rate variability in OSAS patients. Eur Rev Med Pharmacol Sci. 2020 Feb;24(4):2037-2053. doi: 10.26355/eurrev_202002_20382
  4. Ozsu S, Abul Y, Gulsoy A, Bulbul Y, Yaman S, Ozlu T. (2012). Red Cell Distribution Width in Patients with Obstructive Sleep Apnea Syndrome. Lung, 190(3), 319–326. doi:10.1007/s00408-012-9376-x
  5. Davi G, Patrono C. (2007). Platelet Activation and Atherothrombosis. New England Journal of Medicine, 357(24), 2482–2494. doi:10.1056/nejmra071014
  6. Park Y, Schoene N, Harris W. (2002). Mean platelet volume as an indicator of platelet activation: methodological issues. Platelets, 13(5-6), 301–306. doi:10.1080/095371002220148332
  7. Giles H, Smith RE, Martin JF. (1994). Platelet glycoprotein IIb-IIIa and size are increased in acute myocardial infarction. European Journal of Clinical Investigation, 24(1), 69–72. doi:10.1111/j.1365-2362.1994.tb02062.x
  8. Nena E, Papanas N, Steiropoulos P, Zikidou P, Zarogoulidis P, Pita E, Constantinidis TC, Maltezos E, Mikhailidis DP, Bouros D. (2011). Mean Platelet Volume and Platelet Distribution Width in non-diabetic subjects with Obstructive Sleep Apnoea Syndrome: New indices of severity? Platelets, 23(6), 447–454. doi:10.3109/09537104.2011.632031
  9. Vazzana N, Ganci A, Cefalu AB, Lattanzio S, Noto D, Santoro N, Saggini R, Puccetti L, Averna M, Davi G. (2013). Enhanced Lipid Peroxidation and Platelet Activation as Potential Contributors to Increased Cardiovascular Risk in the Low‐HDL Phenotype. Journal of the American Heart Association, 2(2). doi:10.1161/jaha.113.000063
  10. Podrez EA. (2010). Anti-oxidant properties of high-density lipoprotein and atherosclerosis. Clinical and Experimental Pharmacology and Physiology, 37(7), 719–725. doi:10.1111/j.1440-1681.2010.05380.x
  11. Avci E, Kiris T, Demirtas AO, Kadi H. (2018). Relationship between high-density lipoprotein cholesterol and the red cell distribution width in patients with coronary artery disease. Lipids in Health and Disease, 17(1). doi:10.1186/s12944-018-0709-5
  12. Varol E, Aksoy F, Bas HA, Ari H, Ozaydin