Journals / Archives of Clinical and Experimental Medicine / 2021 / Cilt: 6 - Sayı: 2

Evaluation of the protective effect of Red Ginseng on lipid profile, endothelial and oxidative damage after splenectomy in rats

Ratlarda splenektomi sonrası Red Ginseng’in lipit profili, endotel ve oksidatif hasar üzerinde koruyucuetkisinin değerlendirilmesi

Pages
43–49
Publication Date
2022-10-12
DOI
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⚡ TL;DR(Too Long; Didn't Read)

Results: The RG group had reduced significantly total cholesterol (TC), triglyceride (TG), and very low density lipoprotein (VLDL) levels than the control group (p

📌 3 Key Takeaways

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Objective & Hypothesis:Aim: It was aimed to examine the effects of Red Ginseng (RG), which has anti-inflammatory and antioxidant properties, on the histopathological alterations and lipid metabolism following splenectomy.
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Key Findings & Data:Methods: Rats were randomly divided into 3 groups of 10 rats each.
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Conclusion & Impact:Results: The RG group had reduced significantly total cholesterol (TC), triglyceride (TG), and very low density lipoprotein (VLDL) levels than the control group (p
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Aim: It was aimed to examine the effects of Red Ginseng (RG), which has anti-inflammatory and antioxidant properties, on the histopathological alterations and lipid metabolism following splenectomy. Methods: Rats were randomly divided into 3 groups of 10 rats each. Only laparotomy was conducted in group 1 (sham). In group 2 (control), splenectomy was performed but no therapy was offered. Splenectomy was performed and RG extract was supplied orogastrically at a dosage of 100mg/kg/day for 28 days in group 3 (RG group). At the end of the 28-day period, tissue samples were obtained for the assessment of histopathological alterations in the vascular, intestinal, and lung tissues, and blood samples were obtained for biochemical analysis. Results: The RG group had reduced significantly total cholesterol (TC), triglyceride (TG), and very low density lipoprotein (VLDL) levels than the control group (p

Özet

Amaç: Anti-inflamatuar ve antioksidan etkili red ginsegin splenektomi sonrası görülen histopatolojik değişiklikler ve lipid profili üzerindeki etkisi araştırıldı. Yöntemler: Sıçanlar rastgele her biri 10 sıçandan oluşan 3 gruba ayrıldı. Grup 1'de (sham), sadece laparotomi yapıldı. Grup 2'de (kontrol), splenektomi uygulandı fakat ek hiçbir tedavi uygulanmadı. Grup 3'te (Red ginseng grubu), splenektomi yapıldı ve Red Ginseng (RG) ekstresi orogastrik yoldan 100 mg / kg / gün doz olarak 28 gün süreyle uygulandı. 28 günün sonunda vasküler, intestinal ve akciğer dokularındaki histopatolojik değişiklikler incelemesi için doku örnekleri alındı ve biyokimyasal analiz için kan örnekleri alındı. Bulgular: Total kolestrol (TC), trigliserit (TG) ve çok düşük yoğunluklu lipoprotein (VLDL) düzeyleri kontrol grubuna göre RG grubunda anlamlı olarak azalmıştır (p

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Cite This Article

ŞENLİKÇİ, A., PEKÇİCİ, M. R., DURHAN, A., ERGÜDER, E., SÜLEYMAN, M., ERSAK, C., GÖNÜLTAŞ, M. A., BAĞ, Y. M., KOŞMAZ, K., BOSTANCI, M. T., BARLAS, A. M., HÜCÜMENOĞLU, S., ŞENEŞ, M., KUŞABBİ, İ. A. (2022). Evaluation of the protective effect of Red Ginseng on lipid profile, endothelial and oxidative damage after splenectomy in rats. Archives of Clinical and Experimental Medicine, Cilt: 6 - Sayı: 2, 43–49. https://ajindex.com/articles/447811

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