Factor V leiden mutation in Behçet's disease

Objective & Hypothesis:Background: Behçet's disease is a primary vasculitis of unknown etiology that characterized by high tendency to venous thrombosis.

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Key Findings & Data:Arg506Gln) has been found to be strongly associated with venous thrombosis.

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Conclusion & Impact:FV-L appears to be an additional risk factor for the development of venous thrombosis in Behçet's disease.

🔬Design:Research Article

📍Scope:Comprehensive Sample

⚙️Variables:Domain Parameters

Abstract

Background: Behçet's disease is a primary vasculitis of unknown etiology that characterized by high tendency to venous thrombosis. Mechanism of thrombosis remains unknown. A mutation in the coagulation factor V, namely FV Leiden (FV-L, Factor V. Arg506Gln) has been found to be strongly associated with venous thrombosis. Methods: In this study we examined the frequency of FV-L mutation in our patients with Behçet's disease by using polymerase chain reaction. Thirty patients with Behçet's disease were included in this study and 12 of them have had also deep venous thrombosis that was demonstrated by Doppler ultrasonography. Results: FV-L mutation was found in 7 of 30 (23.3%) patients with Behçet's disease while in 23 of 264(8.7%)healthy controls(p=0.02). Five of 12(42%) Behçet's disease patients with venous thrombosis had FV-L mutation while only 2 (11%) patients without venous thrombosis had FV-L mutation that was not significant (p=0.06). Conclusion: We conclude that the frequency of FV-L mutation in Behçet's disease is higher than that of normal population. FV-L appears to be an additional risk factor for the development of venous thrombosis in Behçet's disease.

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Cite This Article

SOY, M., ERKEN, E., TANRIVERDİ, K., KOÇAK, R., ÖZBEK, S. (2022). Factor V leiden mutation in Behçet's disease. Annals of Medical Sciences, Cilt: 9 - Sayı: 1, 22–23. https://ajindex.com/articles/447502

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References (1)

Koç Y, Güllü I, Akipek G. Vascular involvement in Behçet's disease J Rheumatol 1992;19:402-410 2. Esmon CT. Protein C: Biochemistry, physiology and clinical applications. Blood, 1983;62:1155-58 3. Dahlback B, Carllson M, Svensson PJ. Familial thrombophilia due to a previously unrecognized mechanism characterized by poor anticoagulant response to activated protein C: Prediction of a cofactor to activated protein C. Proc Natl Acad Sci USA, 1993;90:1004 4. Bick RL, Kaplan H. Syndromes of thrombosis and hypercoagulability, congenital and acquired causes of thrombosis. The Medical Clinics of North America, 1998; 82:409-458 5. Gürgey A, Mesci L, Renda Y, Olcay L, Koçak N, Erdem G. Factor V Leiden mutation in children with thrombosis. Am J Hematol, 1996;53:37-39 6. Gürgey A, Mesci L. The prevalence of FV Leiden mutation in Turkish population. Turk J Pediatr, 1997;39:310-15. 7. Gül A, Özbek U, Öztürk C, Inanç M, Koniçe M, Özçelik T. Coagulation factor V gene mutation increases the risk of venous thrombosis in Behçet's disease. Br J Rheumatol, 1996;35:1178-1180. 8. Öner AF, Gürgey A, Gürler A, Mesci L. Factor V Leiden mutation in patients with Behçet's disease. J Rheumatol, 1998;25:496-98 9. International Study Group for Behçet's Disease. Criteria for diagnosis of Behçet's Disease. Lancet 1990; 335: 1078-80. 10. Bertina RM, Koeleman BPC, Koster T, Rosendaal FR, Dirven RJ, de Ronde H, van der Valden PA, Reitsma PH. Nature 1994,369;64-67 11. Chajek T, Fainaru M. Behçet's disease with decreased fibrinolysis and superior vena caval occlusion BMJ, 1973;1:782-83. 12. L Mammo, ADalaan, S Bahabri, J Saour. Association of Factor V Leiden and Behçet's disease. VII th International Conference on Behçet's disease, Tunis, October 10-11 1996. p 544. 13. Lesprit P, Wechsler B, Piette JC, Boutin LTHD, Godeau P, Gelas MA, Aiach M. Activated protein C resistance caused by factor V Arg Gln mutation has no role in thrombotic manifestations of Behçet's disease (Letter). Ann Rheum Dis, 1995;54:860.