Journals / Annals of Medical Sciences / 2001 / Cilt: 10 - Sayı: 3

Glutathione concentration, glutathione peroxidase and superoxide dismutase activity of erythrocytes in the early onset of acute myocardial infarction

Pages
110–112
Publication Date
2022-10-10
DOI
—
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⚡ TL;DR(Too Long; Didn't Read)

The glutathione peroxidase (p

📌 3 Key Takeaways

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Objective & Hypothesis:Purpose: During the past few years, considerable interest has been focused on the possible role of oxygen free radicals in the pathogenesis of postischemic myocardial disfunction after acute myocardial infarction.
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Key Findings & Data:Methods: The aim of this study was to evaluate the erythrocyte superoxide dismutase and glutathione peroxidase activities, and glutathione concentration of erythrocyte in 45 patients with acute myocardial infarction.
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Conclusion & Impact:The glutathione peroxidase (p
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Purpose: During the past few years, considerable interest has been focused on the possible role of oxygen free radicals in the pathogenesis of postischemic myocardial disfunction after acute myocardial infarction. Methods: The aim of this study was to evaluate the erythrocyte superoxide dismutase and glutathione peroxidase activities, and glutathione concentration of erythrocyte in 45 patients with acute myocardial infarction. Measurements from 45 healthy subjects were used as controls. The blood samples of patients were taken in the first 6 hour of the acute myocardial infarction. Results: The patients and controls were stratified according to their ages into three levels. The glutathione peroxidase (p

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Cite This Article

ESKANDARİ, H. G., ACARTÜRK, E., YÜREGİR, G. T., BELGE, E., DEMİR, M. (2022). Glutathione concentration, glutathione peroxidase and superoxide dismutase activity of erythrocytes in the early onset of acute myocardial infarction. Annals of Medical Sciences, Cilt: 10 - Sayı: 3, 110–112. https://ajindex.com/articles/447448

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References (19)

  1. Jacob RA, and Burri BJ. Oxidative damage and defense. Am J Clin Nutr 1996; 63: 985-990
  2. Chandra M, Chandra N, Agrawal R, et al. The free radical system in ischaemic heart disease. Intern J Cardiol 1994; 43: 121-125
  3. Ferrari R, Ceconi C, Curello S, et al. Oxygen - mediated myocardial damage during ischemia and reperfusion; role of the cellular defences against oxygen toxicity. J Mol Cell Cardiol 1985; 17: 937-945
  4. Burton KP, McCord JM, Ghai G. Myocardial alterations due to free-radical generation. Am J Physiol 1984; 246: 776-783
  5. Doroshow JH, Locher GY, Myers CE. Enzymatic defences of the mouse heart against reactive oxygen metabolites. J Clin Invest 1980; 65: 128-135
  6. Meister A. Glutathione metabolism and its selective modification. J Biol Chem 1988; 263: 17205-17208
  7. Carrasquedo F, Glanc M, Fraga CG. Tissue damage in acute myocardial infarction: selective protection by vitamin E. Free Radic Biol Med 1999; 26: 1587-1590
  8. G Batist, J Norton, AG Katki, et al. Cardiac and red blood glutathione peroxidase: Results of a prospective randomized trial in patients on total parenteral nutrition. Cancer Res 1985; 45: 5900-5903
  9. Beutler E. Red Cell Metabolism, A Manual of Biochemical Methods. New York: Grune & Stratton Inc., 1971: 112-114
  10. Beutler E. Red Cell Metabolism, A Manual of Biochemical Methods. New York: Grune & Stratton Inc., 1971: 74-75
  11. Randox manual procedures, third edition Super Oxide Dismutase
  12. Ferrari R, Agnoletti L, Comini L, et al. Oxidative stress during myocardial ischaemia and heart failure. Eur Heart J 1998; 19:2-11
  13. Roth E, Török B, Zsoldos T, et al. Lipid peroxidation and scavanger mechanisms in experimentally induced heart infarcts. Basic Res Cardiol 1985; 80: 530-536
  14. Gromadzinska J, Sklodowska M. Erythrocyte glutathione peroxidase and myocardial infarction. JAMA 1990; 263: 949-950
  15. Konukoglu D, D Akcay, T Erdem. T Susceptibility of erythrocyte lipids to oxidation and erythrocyte antioxidant status in myocardial infarction. Clin Biochem 1998; 31: 667-671
  16. Kok FJ, Hofman A, Witteman JC, et al. Decreased selenium levels in AMI. JAMA 1989; 261: 1161-1164
  17. Bor MV, Çevik C, Uslu I, et al. Selenium levels and glutathione peroxidase activities in patients with acute myocardial infarction. Circulation 1999; 100: 2254-2259
  18. Usal A, Acartürk E, Yüregir G, et al. Decreased glutathione levels in acute myocardial infarction. Jpn Heart J 1996; 37: 177-182
  19. Usui A, Kato K, Tsuboi H, Sone T,