Journals / Annals of Medical Research / 2018 / Cilt: 25 - Sayı: 4

Chemical warfare agents and treatment strategies

Pages
776–782
Publication Date
2022-10-12
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

For this purpose; we discussed the serious effects of chemical warfare agents on human health and environment, post-exposure applications and pharmacological treatment options.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Chemical agents; is the general name of substances known to have toxic effects on the environment, which cause a large number of deaths and disabilities in a short period of time.
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Key Findings & Data:Deaths only due to nerve agents are thought to exceed 5 millions in recent wars.
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Conclusion & Impact:For this purpose; we discussed the serious effects of chemical warfare agents on human health and environment, post-exposure applications and pharmacological treatment options.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Chemical agents; is the general name of substances known to have toxic effects on the environment, which cause a large number of deaths and disabilities in a short period of time. These agents are divided into subclasses such as blister, nerve, choking, incapacitating/behavior altering, and asphyxiants/blood agents. In addition to the short-term effects of these agents there may be long-term reflections which affect the next generation. The previous century has been an important period in terms of observing the problems arising from the usage of the agents during wars. Deaths only due to nerve agents are thought to exceed 5 millions in recent wars. Especially the situation that the World War II has emerged shows the magnitude of the use of chemical agents. Due to these detrimental effects, their usage is restricted or prohibited by various international organizations. Despite these obstacles, chemical agents have been used by some countries and terrorist groups. Effects of these agents can take part vary from basic symptoms such as nose irritation to serious problems such as respiratory arrest. Healthcare professionals working in the management of exposure to these agents should have sufficient knowledge and be aware of their effects on the body. For this purpose; we discussed the serious effects of chemical warfare agents on human health and environment, post-exposure applications and pharmacological treatment options.

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Cite This Article

PARLAKPİNAR, H., POLAT, S., GUNATA, M. (2022). Chemical warfare agents and treatment strategies. Annals of Medical Research, Cilt: 25 - Sayı: 4, 776–782. https://ajindex.com/articles/447365

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References (8)

  1. Syria’s latest atrocity: Assad kills at least 85 with chemical weapons https://www.economist.com/middle-east-and-africa/2017/04/08/assad-kills-at-least-85-with-chemical-weapons. access date 08.10.2018
  2. Chauhan S, Chauhan S, D’Cruz R, et al. Chemical warfare agents. Environ Toxicol and Pharmacol 2008;26:113-22. D’Agostino P. Chemical warfare agents. In: Bogusz MJ, ed. Forensic Science Handbook of Analytical Separations. 2 nd edition. Alberta: Elsevier BV; 2008. p. 839-72.WHO concerned about suspected chemical attacks in Syria. http://www.who.int/news-room/detail/11-04-2018-who-concerned-about-suspected-chemical-attacks-in-syria access date 08.4.2018 Syria attack: Chemical weapons inspectors retrieve samples from Douma. https://www.independent.co.uk/news/world/middle-east/syria-douma-chemical-weapons-attack-latest-eastern-ghouta-russia-assad-a8315746.html access date 08.4.2018 Schwenk M. Chemical warfare agents. Classes and targets. Toxicol Lett 2018;293:253-63.
  3. Bessac BF, Jordt SE. Breathtaking TRP channels: TRPA1 and TRPV1 in airway chemosensation and reflex control. Physiology (Bethesda) 2008;23:360-70.
  4. Paromov V, Suntres Z, Smith M, et al. Sulfur mustard toxicity following dermal exposure: role of oxidative stress, and antioxidant therapy. J Burns Wounds 2007;7:60-85.
  5. Li C, Srivastava RK, Weng Z, et al. Molecular mechanism underlying pathogenesis of lewisite-induced cutaneous blistering and inflammation: chemical chaperones as potential novel antidotes. Am J Pathol 2016;186:2637-49. Centers for Disease Control and Prevention (CDC)-Emergency Response Safety and Health Database: Blister Agent: LEWISITE (L), The National Institute for Occupational Safety and Health(NIOSH). https://www.cdc.gov/niosh/ershdb/emergencyresponsecard_29750006.html access date: 08.8. 2018
  6. Eddleston M, Chowdhury FR. Pharmacological treatment of organophosphorus insecticide poisoning: the old and the (possible) new. Br J Clin Pharmacol 2016;81:462-70.
  7. Eddleston M, Buckley NA, Eyer P, et al. Management of acute organophosphorus pesticide poisoning. Lancet 2008;371:597-607. Fraser TR. On the characters, actions, and therapeutic use of the ordeal bean of Calabar. Edinburgh Medical Journal 1863;9:36-56.
  8. Bennion BJ, Essiz SG, Lau EY, et al. A wrench in the works of human acetylcholinesterase: soman induced conformational changes revealed by molecular dynamics simulations. PLoS One 2015;10(4): e0121092. Wiener SW, Hoffman RS. Nerve agents: Acomprehensive review. J Intensive Care Med 2004;19