Evaluation of neutrophil-to-lymphocyte ratio as a marker of inflammatory response in spondylodiscitis

Hemogram parameters of the cases in both groups; white blood cell, C-reactive protein, erythrocyte sedimentation rate, and neutrophil-to-lymphocyte ratio were statistically compared.Results: Patients in the spondylodiscitis group, compared to healthy volunteers had statistically significant neutrophil-to-lymphocyte ratio value.Conclusion: Especially in cases where the diagnosis of spondylodiscitis is not assured, the neutrophil-to-lymphocyte ratio parameter, which is less costly than other diagnostic methods and the analysis results of which can be obtained in a shorter time, may be used to support clinical diagnosis.

📌 3 Key Takeaways

🎯

Objective & Hypothesis:Aim: Spondylodiscitis, if not diagnosed on time, can cause morbidity or mortality at high rates.

📊

Key Findings & Data:This study was carried out with the aim of testing the hypothesis that “neutrophil-to-lymphocyte ratio can be used” especially in cases where it is difficult to diagnose spondylodiscitis.Material and Methods: This study involved 24 patients admitted to the State Hospital of Ministry of Health and Namik Kemal University for spondylodiscitis between January2014 and June2017.

💡

Conclusion & Impact:Hemogram parameters of the cases in both groups; white blood cell, C-reactive protein, erythrocyte sedimentation rate, and neutrophil-to-lymphocyte ratio were statistically compared.Results: Patients in the spondylodiscitis group, compared to healthy volunteers had statistically significant neutrophil-to-lymphocyte ratio value.Conclusion: Especially in cases where the diagnosis of spondylodiscitis is not assured, the neutrophil-to-lymphocyte ratio parameter, which is less costly than other diagnostic methods and the analysis results of which can be obtained in a shorter time, may be used to support clinical diagnosis.

🔬Design:Research Article

📍Scope:Comprehensive Sample

⚙️Variables:Domain Parameters

Abstract

Aim: Spondylodiscitis, if not diagnosed on time, can cause morbidity or mortality at high rates. This study was carried out with the aim of testing the hypothesis that “neutrophil-to-lymphocyte ratio can be used” especially in cases where it is difficult to diagnose spondylodiscitis.Material and Methods: This study involved 24 patients admitted to the State Hospital of Ministry of Health and Namik Kemal University for spondylodiscitis between January2014 and June2017. After excluding the cases that did not meet the inclusion criteria (n=6), the remaining cases (n=24) were referred to as the study group. A control group was created from healthy volunteers (n=24) who applied for routine physical checkups at the clinic between the same dates and who were similar in terms of age, sex, and body mass index to the study group. Hemogram parameters of the cases in both groups; white blood cell, C-reactive protein, erythrocyte sedimentation rate, and neutrophil-to-lymphocyte ratio were statistically compared.Results: Patients in the spondylodiscitis group, compared to healthy volunteers had statistically significant neutrophil-to-lymphocyte ratio value.Conclusion: Especially in cases where the diagnosis of spondylodiscitis is not assured, the neutrophil-to-lymphocyte ratio parameter, which is less costly than other diagnostic methods and the analysis results of which can be obtained in a shorter time, may be used to support clinical diagnosis.

🔖

Cite This Article

AKGÜN, F. S., BİLİR, B., KARAARSLAN, N., DOGAN, M., CALISKAN, T., YILMAZ, İ., ATES, O. (2022). Evaluation of neutrophil-to-lymphocyte ratio as a marker of inflammatory response in spondylodiscitis. Annals of Medical Research, Cilt: 25 - Sayı: 2, 252–257. https://ajindex.com/articles/447357

📄 Full Text PDF Viewer

Open in New Tab ↗

↗New Tab

📄

PDF görüntüleyici hazırlanıyor...

References (10)

Aktar F, Tekin R, Bektaş MS, Güneş A, Köşker M, Ertuğrul S, et al. Diagnostic role of inflammatory markers in pediatric Mylona E, Samarkos M, Kakalou E, Fanourgiakis P, Skoutelis A. Pyogenic vertebral osteomyelitis: a systematic review of clinical characteristics. Semin Arthritis Rheum 2009;39(1):10-7.
Lemaignen A, Ghout I, Dinh A, Gras G, Fantin B, Zarrouk V, et al. Characteristics of and risk factors for severe neurological deficit in patients with pyogenic vertebral osteomyelitis: a case-control study. Medicine (Baltimore) 2017;96(21):e6387. Niemier K, Schindler M, Volk T, Baum K, Wolf B, Eberitsch J, et al. Efficacy of epidural steroid injections for chronic lumbar pain syndromes without neurological deficits. A randomized, double blind study as part of a multimodal treatment concept. Schmerz 2015;29(3):300-7.
Sur A, Tsang K, Brown M, Tzerakis N. Management of adult spontaneous spondylodiscitis and its rising incidence. Ann R Coll Surg Engl 2015;97(6):451-5.
Wang X, Tao H, Zhu Y, Lu X, Hu X. Management of postoperative spondylodiscitis with and without internal fixation. Turk Neurosurg 2015;25(4):513-8. Fransen BL, de Visser E, Lenting A, Rodenburg G, van Zwet AA, Gisolf EH. Recommendations for diagnosis and treatment of spondylodiscitis. Neth J Med 2014;72(3):135-8.
Madert J, Liem M, Frosch KH, Niemeyer T. Dorsolateral access and interbody spinal fusion in spondylodiscitis of the thoracolumbar spine (TLIF technique). Oper Orthop Traumatol 2013;25(3):262-72.
Pola E, Autore G, Formica VM, Pambianco V, Colangelo D, Cauda R, et al. New classification for the treatment of pyogenic spondylodiscitis: validation study on a population of 250 patients with a follow-up of 2 years. Eur Spine J 2017;26(9):2476-77.
Tao C, Wang J, Hu X, Ma J, Li H, You C. Clinical value of neutrophil to lymphocyte and platelet to lymphocyte ratio after aneurysmal subarachnoid hemorrhage. Neurocrit Care 2017;26(3):393-401.
Wang PF, Song HW, Cai HQ, Kong LW, Yao K, Jiang T, et al. Preoperative inflammation markers and IDH mutation status predict glioblastoma patient survival. Oncotarget 2017;8(30):50117-23.
Chen W, Yang J, Li B, Peng G, Li T, Li L, et al. Neutrophil to lymphocyte ratio as a novel predictor of outcome in patients with severe traumatic brain injury. J Head Trauma Rehabil 2018;33(1):53-9.
Bilir B, Isyar M, Yilmaz I, Saracoglu GV, Cakmak S, Dogan M, et al. Evaluation of neutrophil-to-lymphocyte ratio as a marker of inflammatory response in septic arthritis. European Journ