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Journals / Annals of Medical Research / 2018 / Cilt: 25 - Sayı: 4

A retrospective study on the effects of diabetes mellitus on perioperative fibrinogen and bleeding amount in coronary artery bypass surgery patients

Ersagun TUĞCUGİL
Ahmet BEŞİR
Ahmet SEN
Başar ERDİVANLI
Pages
643–647
Publication Date
2022-10-12
DOI
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Postoperative bleeding amount, erythrocyte, and fibrinogen transfusion need were found to be significantly lower in Group D compared to Group C (p = 0.04, p = 0.01, and p< 0.001, respectively).Conclusion: Diabetic patients had decreased amount ofpostoperative bleeding, possibly due to a thrombotic tendency caused by chronic inflammation related to diabetes mellitus.

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Objective & Hypothesis:Aim: In this study, the effects of changes in the coagulation system of diabetic patients that undergo heart surgery on postoperative bleeding amount and complications was investigated.Material and Methods: A total of 106 patients (35 females, 71 males) were retrospectively examined in the study.
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Key Findings & Data:Patients were divided into two groups: diabetic (Group D, n = 47) and non-diabetic (Group C, n = 59).
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Conclusion & Impact:Postoperative bleeding amount, erythrocyte, and fibrinogen transfusion need were found to be significantly lower in Group D compared to Group C (p = 0.04, p = 0.01, and p< 0.001, respectively).Conclusion: Diabetic patients had decreased amount ofpostoperative bleeding, possibly due to a thrombotic tendency caused by chronic inflammation related to diabetes mellitus.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Aim: In this study, the effects of changes in the coagulation system of diabetic patients that undergo heart surgery on postoperative bleeding amount and complications was investigated.Material and Methods: A total of 106 patients (35 females, 71 males) were retrospectively examined in the study. Patients were divided into two groups: diabetic (Group D, n = 47) and non-diabetic (Group C, n = 59). Preoperative and postoperative hematologic values, postoperative bleeding, and transfusion amounts of all groups were recorded.Results: Preoperative and postoperative fibrinogen and C-reactive protein (CRP) values in Group D were significantly higher compared to those in Group C (p< 0.05 and p< 0.01, respectively). Postoperative bleeding amount, erythrocyte, and fibrinogen transfusion need were found to be significantly lower in Group D compared to Group C (p = 0.04, p = 0.01, and p< 0.001, respectively).Conclusion: Diabetic patients had decreased amount ofpostoperative bleeding, possibly due to a thrombotic tendency caused by chronic inflammation related to diabetes mellitus.

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Cite This Article

TUĞCUGİL, E., BEŞİR, A., SEN, A., ERDİVANLI, B. (2022). A retrospective study on the effects of diabetes mellitus on perioperative fibrinogen and bleeding amount in coronary artery bypass surgery patients. Annals of Medical Research, Cilt: 25 - Sayı: 4, 643–647. https://ajindex.com/articles/447354

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References (13)

  1. Hartmann M, Sucker C, Boehm O, et al. Efeects of cardiac surgery on hemostasis. Transfus Med Rev 2006;20:230-41. Waldén K, Jeppsson A, Nasic S, et al. Low preoperative fibrinogen plasma concentration is associated with excessive bleeding after cardiac operations. Ann Thorac Surg 2014;97:1199-206. Rich JB. The efficacy and safety of aprotinin use in cardiac surgery. Ann Thorac Surg 1998;66:6-11.
  2. Ranucci M, Baryshnikova E, Castelvecchio S, et al. Surgical and Clinical Outcome Research (SCORE) Group. Major bleeding, transfusions, and anemia: the deadly triad of cardiac surgery. Ann Thorac Surg 2013;96:478-85.
  3. Levy JH, Dutton RP, Hemphill III JC, et al. Multidisciplinary approach to the challenge of hemostasis. Anesth Analg 2010;110:354-64.
  4. Kubal C, Srinivasan AK, Grayson AD, et al.Effect of risk-adjusted diabetes on mortality and morbidity after coronary artery bypass surgery. Ann Thorac Surg 2005;79:1570-76.
  5. Feng Jun MD, Frank W Sellke M. Microvascular dysfunction in patients with diabetes after cardioplegic arrest and cardiopulmonary bypass. Curr Opin Cardiol 2016;31: 618–24.
  6. Potz BA, Scrimgeour LA, Feng J, et al. Diabetes and Cardioplegia. J Nat Sci 2017;3:394:1-6.
  7. Pomero F, Di Minno MN, Fenoglio L, et al. Is diabetes a hypercoagulable state? A critical appraisal. Acta Diabetol 2015;52:1007-16. Nomura S. Dynamic role of microparticles in type 2 diabetes mellitus. Curr Diabetes Rev 2009;5:245–51.
  8. Gielen C, Dekkers O, Stijnen T, et al. The effects of pre- and postoperative fibrinogen levels on blood loss after cardiac surgery: a systematic review and meta-analysis. Interact Cardiovasc Thorac Surg 2014;18: 292-8.
  9. Camila Takao Lopes, Talita Raquel Dos Santos, Evelise Helena Fadini Reis Brunori, et al. Excessive bleeding predictors after cardiac surgery in adults: integrative review. Clin Nurs 2015;24:046–62.
  10. Rafiq S, Johansson PI, Ostrowski SR, et al. Hypercoagulability in patients undergoing coronary artery bypass grafting: Prevalence, patient characteristics and postoperative outcome. Eur J Cardiothorac Surg 2012;41:550-5.
  11. Bochsen L, Nielsen AB, Steinbrüchel DA, Johansson PI. Higher thromboelastograph platelet reactivity in cardiac surgery patients than in blood donors, Scand Cardiovascular J 2007; 41: 321-4.
  12. Sato H, Carvalho G, Sato T. The Association of Preoperative Glycemic Control, Intraoperative Insulin Sensitivity, and Outcomes after Cardiac Surgery, J Clin Endocrinol Metab 2010;95:4338-44.
  13. Kristensen KL, Rauer LJ, Mortensen PE, et al. Reoperation for