TheTpe-interval, Tpe/QT, and Tpe/QTc were significantly prolonged in POF group than control subjects (p
📌 3 Key Takeaways
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Objective & Hypothesis:Aim: Ventricular repolarization were evaluated in patients who had POF by using novel electrocardiographic parameters includingTpe-interval and Tpe/QT and Tpe/QTc ratios.
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Key Findings & Data:However, none have examined ventricular repolarization in this respect.Materials and Methods: This cross-sectional study included 60 female patients with POF (mean 32.6±4.7 years) and 54 controlhealthy female subjects (mean 30.9±4.6 years).All electrocardiogram (ECG) measurements were performed by a cardiologist usinga computer, and the Tpe-interval, Tpe/QT, and Tpe/QTc were compared between groups.Results: There were no significant differences between groups in terms of baseline characteristics and laboratory parameters.
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Conclusion & Impact:TheTpe-interval, Tpe/QT, and Tpe/QTc were significantly prolonged in POF group than control subjects (p
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters
Abstract
Aim: Ventricular repolarization were evaluated in patients who had POF by using novel electrocardiographic parameters includingTpe-interval and Tpe/QT and Tpe/QTc ratios. A few studies have investigated the association between premature ovarian failure(POF) and cardiovascular diseases. However, none have examined ventricular repolarization in this respect.Materials and Methods: This cross-sectional study included 60 female patients with POF (mean 32.6±4.7 years) and 54 controlhealthy female subjects (mean 30.9±4.6 years).All electrocardiogram (ECG) measurements were performed by a cardiologist usinga computer, and the Tpe-interval, Tpe/QT, and Tpe/QTc were compared between groups.Results: There were no significant differences between groups in terms of baseline characteristics and laboratory parameters. TheTpe-interval, Tpe/QT, and Tpe/QTc were significantly prolonged in POF group than control subjects (p
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Cite This Article
OVAYOLU, A., YILMAZ, M., SARAÇOĞLU, E., ÇEKİCİ, Y., KILIÇ, S., DÜZEN, İ. V. (2022). Evaluation of Tpe-interval and Tpe/QT, Tpe/QTc ratios in patients with premature ovarian failure. Annals of Medical Research, Cilt: 26 - Sayı: 10, 2233–2239. https://ajindex.com/articles/447140
Jankowska K. Premature ovarian failure. Przeglad menopauzalny= Menopause review 2017;16:51
Wellons M, Ouyang P, Schreiner PJ, et al. Early menopause predicts future coronary heart disease and stroke: the Multi-Ethnic Study of Atherosclerosis (MESA). Menopause (New York, NY) 2012;19:1081
Sims C, Reisenweber S, Viswanathan PC, et al. Sex, age, and regional differences in L-type calcium current are important determinants of arrhythmia phenotype in rabbit hearts with drug-induced long QT type 2. Circulation research 2008;102:86-100
Canpolat U, Tokgözoğlu L, Yorgun H, et al. The association of premature ovarian failure with ventricular repolarization dynamics evaluated by QT dynamicity. Europace 2013;15:1657-63
Sedlak T, Shufelt C, Iribarren C, et al. Sex hormones and the QT interval: a review. Journal of Women’s Health 2012;21:933-41
Merz CNB, Shaw LJ, Azziz R, et al. Cardiovascular disease and 10-year mortality in postmenopausal women with clinical features of polycystic ovary syndrome. Journal of Women’s Health 2016;25:875- 81
Kurokawa J, Kodama M, Clancy CE, et al. Sex hormonal regulation of cardiac ion channels in druginduced QT syndromes. Pharmacology & therapeutics 2016;168:23-8
Ravens U. Sex differences in cardiac electrophysiology. Canadian journal of physiology and pharmacology. 2018;96:985-90
Opthof T, Janse MJ, Meijborg VM, et al. Dispersion in ventricular repolarization in the human, canine and porcine heart. Progress in biophysics and molecular biology. 2016;120:222-35
Srinivasan NT, Orini M, Simon RB, et al. Ventricular stimulus site influences dynamic dispersion of repolarization in the intact human heart. American Journal of Physiology-Heart and Circulatory Physiology. 2016;311:545-54
Porthan K, Viitasalo M, Toivonen L, et al. Predictive Value of Electrocardiographic T-Wave Morphology Parameters and T-Wave Peak to T-Wave End Interval for Sudden Cardiac Death in the General PopulationClinical Perspective. Circulation: Arrhythmia and Electrophysiology. 2013;6:690-6
Prenner SB, Shah SJ, Goldberger JJ, et al. Repolarization heterogeneity: beyond the QT interval. Journal of the American Heart Association 2016;5:003607
Dressler F, Brado J, Odening K. Electromechanical heterogeneity in the heart. Herzschrittmachertherapie Elektrophysiologie 2018;29:43-7. 14
Lang RM, Bierig M, Devereux RB, et al. Recommendations for chamber quantification. European journal of echocardiography 2006;7:79-108. 15