SavedAdd your journal

Journals / Annals of Medical Research / 2019 / Cilt: 26 - Sayı: 11

Sociodemographic characteristics and dynamic thiol/ disulfide homeostasis in pediatric patients presenting with scorpion sting

Serhat DEVECİ
Mahmut DEMİR
Ahmet GÜZELÇİÇEK
Adnan KİRMİT
Pages
2609–2614
Publication Date
2022-10-12
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

While it was found that the levels of the total thiol, disulfide, disulfide/native thiol and disulfide/total thiol were statisticallysignificant higher in the patient group, the native thiol/total thiol ratio was found to be lower at a significant level.Conclusion: The scorpion sting incidents are still an important health problem in Turkey.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Aim: Poisoning from scorpion sting is an important public health problem, and may cause disability and death especially in childhood.In our study, we aimed to evaluate the sociodemographic characteristics, clinical findings, laboratory results and dynamic disulfide/thiol homeostasis as oxidative stress factor of pediatric patients presenting with scorpion sting complaints to our hospital.Material and Methods: Forty patients in the 0-18 age group who admitted to the Pediatric Emergency Outpatient Clinic due toscorpion sting intoxication were included in the patient group, and 38 healthy children in the same age group were included in thecontrol group.
📊
Key Findings & Data:In addition, thiol/disulfide levels in the serums of patients were studied with a new method developed by Erel et al.Results: Forty pediatric patients (57.5% male and 42.5% female) presenting with scorpion sting complaints were included in thestudy.
💡
Conclusion & Impact:While it was found that the levels of the total thiol, disulfide, disulfide/native thiol and disulfide/total thiol were statisticallysignificant higher in the patient group, the native thiol/total thiol ratio was found to be lower at a significant level.Conclusion: The scorpion sting incidents are still an important health problem in Turkey.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Aim: Poisoning from scorpion sting is an important public health problem, and may cause disability and death especially in childhood.In our study, we aimed to evaluate the sociodemographic characteristics, clinical findings, laboratory results and dynamic disulfide/thiol homeostasis as oxidative stress factor of pediatric patients presenting with scorpion sting complaints to our hospital.Material and Methods: Forty patients in the 0-18 age group who admitted to the Pediatric Emergency Outpatient Clinic due toscorpion sting intoxication were included in the patient group, and 38 healthy children in the same age group were included in thecontrol group. Patients’ sociodemographic characteristics, clinical and laboratory findings, treatment modalities and the outcomeswere examined. In addition, thiol/disulfide levels in the serums of patients were studied with a new method developed by Erel et al.Results: Forty pediatric patients (57.5% male and 42.5% female) presenting with scorpion sting complaints were included in thestudy. Results: There was no statistically significant difference among patient and control group with regards to the mean native thiollevels. While it was found that the levels of the total thiol, disulfide, disulfide/native thiol and disulfide/total thiol were statisticallysignificant higher in the patient group, the native thiol/total thiol ratio was found to be lower at a significant level.Conclusion: The scorpion sting incidents are still an important health problem in Turkey. In children with scorpion sting, the thiol/disulfide homeostasis was observed to shift towards the disulfide side, i.e. to the right, indicating an increase in oxidative stress.

🔖

Cite This Article

DEVECİ, S., DEMİR, M., GÜZELÇİÇEK, A., KİRMİT, A. (2022). Sociodemographic characteristics and dynamic thiol/ disulfide homeostasis in pediatric patients presenting with scorpion sting. Annals of Medical Research, Cilt: 26 - Sayı: 11, 2609–2614. https://ajindex.com/articles/447051

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (17)

  1. Dehesa–Davila M, Possani LD. Scorpionizm and serotherapy in Mexico. Toxicon 1994;32:1015 – 8
  2. Possani LD, Becerril B, Delepierre M, Tytgat J. Scorpion toxins specific for Na+ -channels. Eur. J. Biochem1999;264:287-300
  3. Possani LD, Merino E, Corona M, Bolivar F. Becerril B. Peptites and genes coding for scorpion toxins that affect ion – channels. Biochimie 2000;82:861-8
  4. Garcia ML, Gao YD, McManus OB, et al. Potassium channels: from scorpion venom to high–resolution structure. Toxicon 2001;39: 739–48
  5. Gwee MCE, Nirthanan S, Khoo H et al. Autonomic effects of some scorpion venoms and toxins. Clinical and Experimental Pharmacology and Physiology 2002;29:795-801
  6. Erel O, Neselioglu S. A novel and automated assay for thiol/disulfide homeostasis.ClinBiochem 2014;47: 326-32
  7. Guney T, Kanat İF, Alkan A et al. Assessment of serum thiol/disulfide homeostasis in multiple myeloma patients by a new method. Redox Report 2017;22:246- 251
  8. Yucel A, Sanhal CY, Daglar K, Kara O, Uygur D, Erel O. Thiol/disulphide homeostasis in pregnant women with Familial Mediterranean fever. Redox Report 2016:21;287-291
  9. Chippaux JP, Goyffon M. Epidemiology of scorpionism: a global appraisal. Acta Trop 2008;107:71-9
  10. Altınkaynak S, Ertekin V, Alp H. Scorpion envenomation in children. Turk Arch Pediatr 2002;37:48-54
  11. Bosnak M, Yılmaz HL, Ece A et al. Severe scorpion envenomation in children: Management in pediatric intensive care unit. Hum ExpToxicol 2009;28:721-8
  12. Adıgüzel S, Özkan Ö, İnceoğlu B. Epidemiological and clinical characteristicsof scorpionism in children in Sanliurfa, Turkey. Toxicon 2007;49:875-80
  13. Yılmaz F, Arslan ED, Demir A et al. Epidemiologic and clinical characteristics and outcomes of scorpion sting in the southeastern region of Turkey. Turkish Journal of Trauma and Emergency Surgery 2013;19:417-22
  14. Osnaya-Romero N, Medina-Hernandez TJ, Flores Hernandez SS et al. Clinical symptoms observed in children envenomated by scorpion stings, at the children’s hospital from the State of Morelos, Mexico. Toxicon 2001;39:781-5
  15. Prasad R, Mishra OP, Pandey N, et al. Scorpion sting envenomation in children: factors affecting the outcome. Indian J Pediatr 2011;78:544-8
  16. Doğanay Z, Karatas AD, Baydın A et al. Is administration of antivenin necessary for all cases of scorpion envenomation? A case report. Turk J Emerg Med 2006;6:76-80. 17
  17. Dudin AA, Rambaud-Cousson A, Thalji A, Juabeh II, Abu-Libdeh B. Scorpion sting in children