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Journals / Annals of Medical Research / 2019 / Cilt: 26 - Sayı: 12

Comparison of surgery and surgery plus corticosteroid therapy in idiopathic granulomatous mastitis, prospective randomized study

Mehmet PATMANO
Alper AKCAN
Serap DOĞAN
İskender GÜN
Erdoğan SÖZÜER
Abdullah Bahadır ÖZ
Türkmen Bahadır ARIKAN
Pages
2984–2989
Publication Date
2022-10-12
DOI
—
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⚡ TL;DR(Too Long; Didn't Read)

During follow-up, recurrencewas seen in one patient (6.7%) in surgery group and in 3 patients (20%) in steroid group but no significant difference was detectedbetween groups (p>0.05).Conclusion: In patients with granulomatous mastitis, systemic steroid therapy is an effective modality in patients unresponsive toantibiotic therapy after ruling out tuberculosis.

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Objective & Hypothesis:Aim: To compare therapeutic effectiveness of surgery alone with surgery plus corticosteroid in patients with granulomatous mastitis.Material and Methods: The study included 30 patients aged 23-60 years.
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Key Findings & Data:In-group 1, the patients received 375 mg ampicillin-sulbactam (twice daily, p.o.) for a week; than 32 mg prednisolone wasstarted which was gradually tapered (biweekly by 8 mg) over 8 weeks.
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Conclusion & Impact:During follow-up, recurrencewas seen in one patient (6.7%) in surgery group and in 3 patients (20%) in steroid group but no significant difference was detectedbetween groups (p>0.05).Conclusion: In patients with granulomatous mastitis, systemic steroid therapy is an effective modality in patients unresponsive toantibiotic therapy after ruling out tuberculosis.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Aim: To compare therapeutic effectiveness of surgery alone with surgery plus corticosteroid in patients with granulomatous mastitis.Material and Methods: The study included 30 patients aged 23-60 years. The patients were randomly assigned into two groupsby lot. In-group 1, the patients received 375 mg ampicillin-sulbactam (twice daily, p.o.) for a week; than 32 mg prednisolone wasstarted which was gradually tapered (biweekly by 8 mg) over 8 weeks. Surgery was performed 2 weeks after tapering. In-group 2,the patients received 375 mg ampicillin-sulbactam (twice daily, p.o.) for a week and underwent surgery. During 2-years follow-up, allpatients were assessed for etiological factors and recurrence.Results: No significant differences was found in demographic characteristics, smoking habits, oral contraceptive use, presentingcomplaints, physical examination findings, localization and diagnostic tools used between groups. During follow-up, recurrencewas seen in one patient (6.7%) in surgery group and in 3 patients (20%) in steroid group but no significant difference was detectedbetween groups (p>0.05).Conclusion: In patients with granulomatous mastitis, systemic steroid therapy is an effective modality in patients unresponsive toantibiotic therapy after ruling out tuberculosis.

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Cite This Article

PATMANO, M., AKCAN, A., DOĞAN, S., GÜN, İ., SÖZÜER, E., ÖZ, A. B., ARIKAN, T. B. (2022). Comparison of surgery and surgery plus corticosteroid therapy in idiopathic granulomatous mastitis, prospective randomized study. Annals of Medical Research, Cilt: 26 - Sayı: 12, 2984–2989. https://ajindex.com/articles/446947

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