Clinical efficacy and acceptability of 0.25% flurbiprofen mouthwash after periodontal flap surgery: A double-blinded, parallel-group, placebo-controlled, randomized clinical trial
At postoperative 7 days, the early wound healing index was assessed clinically.Results: The mean VAS scores exhibiting postoperative pain were significantly lower in flurbiprofen group compared to placebo group at days 1, 7 and 30 (p
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Objective & Hypothesis:Aim: The aim of the present study was to investigate the analgesic and anti-inflammatory efficacy of 0.25% flurbiprofen mouthwash, and to evaluate its effect on the parameters related to patient morbidity and early wound healing after periodontal flap surgery.Material and methods: Thirty-two patients (19 females and 13 males), diagnosed with moderate periodontitis and presenting at least one quadrant scheduled for periodontal flap surgery, were randomly allocated to either the flurbiprofen group or the placebo group.
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Key Findings & Data:The plaque index (PI), gingival index (GI), probing pocket depth (PPD), bleeding on probing (BOP) and clinical attachment level (CAL) were evaluated at baseline and PI and GI were re-evaluated at 30-day follow-up.
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Conclusion & Impact:At postoperative 7 days, the early wound healing index was assessed clinically.Results: The mean VAS scores exhibiting postoperative pain were significantly lower in flurbiprofen group compared to placebo group at days 1, 7 and 30 (p
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters
Abstract
Aim: The aim of the present study was to investigate the analgesic and anti-inflammatory efficacy of 0.25% flurbiprofen mouthwash, and to evaluate its effect on the parameters related to patient morbidity and early wound healing after periodontal flap surgery.Material and methods: Thirty-two patients (19 females and 13 males), diagnosed with moderate periodontitis and presenting at least one quadrant scheduled for periodontal flap surgery, were randomly allocated to either the flurbiprofen group or the placebo group. The plaque index (PI), gingival index (GI), probing pocket depth (PPD), bleeding on probing (BOP) and clinical attachment level (CAL) were evaluated at baseline and PI and GI were re-evaluated at 30-day follow-up. On postoperative 1, 3, 7, 14 and 30 days, postoperative pain, discomfort, changes in patients’ dietary habits, burning sensation and postoperative swelling were analyzed by using a visual analog scale (VAS). At postoperative 7 days, the early wound healing index was assessed clinically.Results: The mean VAS scores exhibiting postoperative pain were significantly lower in flurbiprofen group compared to placebo group at days 1, 7 and 30 (p
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Cite This Article
OZDEMİR, B., NAZIM, C., IŞLER, S. C., AYDOGAN, M., BAKHISHOV, H., DINC, M. (2022). Clinical efficacy and acceptability of 0.25% flurbiprofen mouthwash after periodontal flap surgery: A double-blinded, parallel-group, placebo-controlled, randomized clinical trial. Annals of Medical Research, Cilt: 26 - Sayı: 3, 510–516. https://ajindex.com/articles/446912
Kinane DF. Causation and pathogenesis of periodontal disease. Periodontol 2000 2001;25:8-20
Irfan UM, Dawson DV, Bissada NF. Epidemiology of periodontal disease: a review and clinical perspectives. J Int Acad Periodontol 2001;3:14-21
Steffens JP, Santos FA, Pilatti GL. The use of etoricoxib and celecoxib for pain prevention after periodontal surgery: a double-masked, parallel-group, placebo-controlled, randomized clinical trial. J Periodontol 2011;82:1238-44
Matthews DC, McCulloch CA. Evaluating patient perceptions as short-term outcomes of periodontal treatment: A comparison of surgical and non-surgical therapy. J Periodontol 1993;64:990-7
Laugisch O, Ramseier CA, Salvi GE, et al. Effects of two different post-surgical protocols including either 0.05% chlorhexidine herbal extract or 0.1 % chlorhexidine on post-surgical plaque control, early wound healing and patient acceptance following standard periodontal surgery and implant placement. Clin Oral Investig 2016;20:2175-83
Haas DA. An update on analgesics for the management of acutepostoperative dental pain. J Can Dent Assoc 2002;68:476-82
Czock D, Keller F, Rasche FM, et al. Pharmacokinetics and pharmacodynamics of systemically administered glucocorticoids. Clin Pharmacokinet 2005;44:61-98
Mishra A, Amalakara J, Avula H, et al. Effect of diclofenac mouthwash on postoperative pain after periodontal surgery. J Clin Diagn Res 2017;11:ZC24-26
Richy F, Rabenda V, Mawet A, et al. Flurbiprofen in the symptomatic management of rheumatoid arthritis: a valuable alternative. Int J Clin Prac 2007;61:1396-406
Dionne RA, Haynes D, Brahim JS, et al. Analgesic effect of sustained-release flurbiprofen administered at the site of tissue injury in the oral surgery model. J Clin Pharmacol 2004;44:1418-24
Battisti N. The evaluation of the analgesic and anti-inflammatory effects of flurbiprofen mouthwash and 100-mg tablets in oral medicine. Minerva Stomatol 1994;43:141-4
Armitage GC. Development of a classification system for periodontal diseases and conditions. Ann Periodontol 1999;4:1-6
Silness J, Löe H. Periodontal disease in pregnancy II. Correlation between oral hygiene and periodontal condition. Acta Odontol Scand 1964;22:121-35
Ainamo J, Bay I. Problems and proposals for recording gingivitis and plaque. Int Dent J 1975;25:229-35
Löe H, Silness J. Periodontal disease in pregnancy I. Prevalence and severity. Acta Odontol Scand 1963;21:533-51