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Journals / Annals of Medical Research / 2019 / Cilt: 26 - Sayı: 8

Can monocyte to HDL ratio be used as an inflammatory marker in children with familial mediterranean fever?

Mesut PARLAK
Fatma DUKSAL
Hatice GUNES
Pages
1453–1457
Publication Date
2022-10-12
DOI
—
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There was no significant difference between these four groups according to MHR (p=0.348).However, MHR revealed a positive correlation with fibrinogen (r=0.604, p

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Objective & Hypothesis:Aim: Familial Mediterranean fever (FMF); is an auto-inflammatory disease characterized by recurrent fever attacks.
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Key Findings & Data:The aim of the study was to evaluate the relationship between MHR and FMF in children.Material and Methods: Sixty-two children with FMF in the attack-free period and 60-age and sex-matched- healthy controls includedin the study.
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Conclusion & Impact:There was no significant difference between these four groups according to MHR (p=0.348).However, MHR revealed a positive correlation with fibrinogen (r=0.604, p
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Aim: Familial Mediterranean fever (FMF); is an auto-inflammatory disease characterized by recurrent fever attacks. Inflammationcontinues even in the attack-free period. Monocyte to high-density lipoprotein cholesterol (HDL-C) ratio (MHR) is an inflammatorymarker that has recently begun to use. The aim of the study was to evaluate the relationship between MHR and FMF in children.Material and Methods: Sixty-two children with FMF in the attack-free period and 60-age and sex-matched- healthy controls includedin the study. Patients divided into subgroups according to their gene mutation type. Monocyte count and HDL-C levels retrieved frommedical records of patients and MHR were calculated from these data.Results: The MHR of individuals were close to each other and there was no statistically significant difference between them ( p>0.05).Twenty-four of the patients had heterozygous, 4 had homozygous, 11 had a compound and 21 had negative mutations. Two of thepatients had no mutation analysis. There was no significant difference between these four groups according to MHR (p=0.348).However, MHR revealed a positive correlation with fibrinogen (r=0.604, p

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Cite This Article

PARLAK, M., DUKSAL, F., GUNES, H. (2022). Can monocyte to HDL ratio be used as an inflammatory marker in children with familial mediterranean fever?. Annals of Medical Research, Cilt: 26 - Sayı: 8, 1453–1457. https://ajindex.com/articles/446901

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