Journals / Annals of Medical Research / 2020 / Cilt: 27 - Sayı: 12

Endocan and Interleukin-6 Levels in Individuals with polycystic ovary syndrome and periodontal inflammation: A prospective cross-sectional stud

Pages
3240–3247
Publication Date
2022-10-12
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

There were significant positive correlations between the serum and saliva endocan and saliva IL-6 values (p

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Aim: Periodontitis and polycystic ovary syndrome (PCOS) are relationship to both chronic low-grade inflammation and systemic inflammation.
📊
Key Findings & Data:The aims of the current cross-sectional study are to determine serum and saliva endocan and interleukin-6(IL-6) levels, and to evaluate the correlation between these two biomarkers in women with periodontitis and PCOS.
💡
Conclusion & Impact:There were significant positive correlations between the serum and saliva endocan and saliva IL-6 values (p
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Aim: Periodontitis and polycystic ovary syndrome (PCOS) are relationship to both chronic low-grade inflammation and systemic inflammation. In spite of common risk factors, the link between periodontitis and PCOS has not yet been clear. The aims of the current cross-sectional study are to determine serum and saliva endocan and interleukin-6(IL-6) levels, and to evaluate the correlation between these two biomarkers in women with periodontitis and PCOS. Materials and Methods: 87 individuals divided into four groups; PCOS with periodontitis (PCOSP), PCOS but periodontally healthy (PCOSPH), systemically healthy with periodontitis (SHP) and control group. Demographics, periodontal parameters, serum and saliva endocan and IL-6 values were evaluated. Results: Serum endocan values in all the study groups were significantly greater than those in the control group. Saliva endocan values in PCOSP group were greater than those in the control group. Serum IL-6 values in both the PCOSP and SHP groups were significantly greater than those in the control group. Saliva IL-6 values in both periodontitis groups were significantly greater than those in the control groups. There were significant positive correlations between the serum and saliva endocan and saliva IL-6 values (p

🔖

Cite This Article

ÇANAKÇI, H., ÇANAKÇI, C. F., SAĞLAM, E., TORAMAN, A., İNGEÇ, M., SEBİN, E. (2022). Endocan and Interleukin-6 Levels in Individuals with polycystic ovary syndrome and periodontal inflammation: A prospective cross-sectional stud. Annals of Medical Research, Cilt: 27 - Sayı: 12, 3240–3247. https://ajindex.com/articles/446877

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (15)

  1. Ozcaka O, Ceyhan BO, Akcali A, et al. Is there an interaction between polycystic ovary syndrome and gingival inflammation? J Periodontol 2012;83:1529- 37
  2. Cekici A, Kantarci A, Hasturk H, et al. Inflammatory and immune pathways in the pathogenesis of periodontal disease. Periodontol 2000 2014;64:57-80
  3. D'Aiuto F, Sabbah W, Netuveli G, et al. Association of the metabolic syndrome with severe periodontitis in a large U.S. population-based survey. J Clin Endocrinol Metab 2008;93:3989-94
  4. Tonetti MS, Van Dyke TE. Periodontitis and atherosclerotic cardiovascular disease: consensus report of the Joint EFP/AAP Workshop on Periodontitisand Systemic Diseases. J Periodontol 2013;84:24-9
  5. Rotterdam ESHRE/ASRM-Sponsored PCOS Consensus Workshop Group. Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome. Fertil Steril 2004;81:19-25
  6. Sabuncu T, Vural H, Harma M. Oxidative stress in polycystic ovary syndrome and its contribution to the risk of cardiovascular disease. Clin Biochem 2001;34:407-13
  7. Spritzer PM, Lecke SB, Satler F, et al. Adipose tissue dysfunction, adipokines, and low-grade chronic inflammation in polycystic ovary syndrome. Reproduction 2015;149:R219-27
  8. Lassalle P, Molet S, Janin A, et al. ESM-1 is a novel human endothelial cell-specific molecule expressed in lung and regulated by cytokines. J Biol Chem 1996;271:20458-64
  9. Rocha SF, Schiller M, Jing D, et al. Esm1 modulates endothelial tip cell behavior and vascular permeability by enhancing VEGF bioavailability. Circ Res 2014;115:581-90
  10. Yang J, Yang Q, Yu S, et al. Endocan: A new marker for cancer and a target for cancer therapy. Biomed Rep 2015;3:279-83
  11. Scherpereel A, Gentina T, Grigoriu B, et al. Overexpression of endocan induces tumor formation. Cancer Res 2003;63:6084-9
  12. Bilir B, Ekiz Bilir B, Yilmaz I, et al. Association of apelin, endoglin and endocan with diabetic peripheral neuropathy in type 2 diabetic patients. Eur Rev Med Pharmacol Sci 2016;20:892-8
  13. Wang XS, Yang W, Luo T, et al. Serum endocan levels are correlated with the presence and severity of coronary artery disease in patients with hypertension. Genet Test Mol Biomarkers 2015;19:124-7
  14. Balta I, Balta S, Koryurek OM, et al. Serum endocan levels as a marker of disease activity in patients with Behcet disease. J Am Acad Dermatol 2014;70:291-6
  15. Icli A, Cure E, Cure MC, et al. Endocan Levels and Subclinical Atherosclerosis in Patients