Journals / Annals of Medical Research / 2019 / Cilt: 26 - Sayı: 12

Sub-clinic atherosclerosis in patients with postprandial reactive hypoglycemia

Pages
2941–2947
Publication Date
2022-10-12
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Subjects underwent echocardiographic examination including EFT and IMT measurementusing transthoracic echocardiography.Results: Postprandial Reactive Hypoglycemia group were marked with higher high-sensitivity C-reactive protein levels (1.67±0.67vs. 1.20±0.52; p= 0.007), carotid intima media thickness (0.65±0.10 vs. 0.50±0.10; p

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Aim: Hypoglycemia is associated with excessive cardiovascular mortality because of the pro-inflammatory and pro-atherothromboticpathway stimulation.
📊
Key Findings & Data:This study aims to determinethe development of sub-clinic atherosclerosis in patients with postprandial reactive hypoglycemia by investigating thickness ofcarotid intima media and epicardial fat, and high-sensitivity C-reactive protein values and their relationships with each other.Material and Methods: 51 patients in total were included in the project, including 28 patients (37.50±10.82 years) who hadhypoglycemia symptoms and who had hypoglycemia during prolonged oral glucose tolerance test and 23 healthy adult volunteers(35.01±10.92 years) as a control group.
💡
Conclusion & Impact:Subjects underwent echocardiographic examination including EFT and IMT measurementusing transthoracic echocardiography.Results: Postprandial Reactive Hypoglycemia group were marked with higher high-sensitivity C-reactive protein levels (1.67±0.67vs. 1.20±0.52; p= 0.007), carotid intima media thickness (0.65±0.10 vs. 0.50±0.10; p
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Aim: Hypoglycemia is associated with excessive cardiovascular mortality because of the pro-inflammatory and pro-atherothromboticpathway stimulation. Hypoglycemia is known to affect the development of sub-clinic atherosclerosis. This study aims to determinethe development of sub-clinic atherosclerosis in patients with postprandial reactive hypoglycemia by investigating thickness ofcarotid intima media and epicardial fat, and high-sensitivity C-reactive protein values and their relationships with each other.Material and Methods: 51 patients in total were included in the project, including 28 patients (37.50±10.82 years) who hadhypoglycemia symptoms and who had hypoglycemia during prolonged oral glucose tolerance test and 23 healthy adult volunteers(35.01±10.92 years) as a control group. Subjects underwent echocardiographic examination including EFT and IMT measurementusing transthoracic echocardiography.Results: Postprandial Reactive Hypoglycemia group were marked with higher high-sensitivity C-reactive protein levels (1.67±0.67vs. 1.20±0.52; p= 0.007), carotid intima media thickness (0.65±0.10 vs. 0.50±0.10; p

🔖

Cite This Article

TUĞCU, A. U., ÇİFTÇİ, F. C., ÇİFTÇİ, Ö. (2022). Sub-clinic atherosclerosis in patients with postprandial reactive hypoglycemia. Annals of Medical Research, Cilt: 26 - Sayı: 12, 2941–2947. https://ajindex.com/articles/446805

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (17)

  1. Hipoglisemi.Endokrinoloji 2011 Edition, Çetinkalp Ş. Ege Üniversitesi Basımevi, İzmir. 2011;289-94
  2. CryerPE. Hypoglycemia. Williams Textbook of Endocrinology. 12 th edition, Editors, Melmed S, Polonsky KS,Larsen PR, Kronenberg HM, USA. Saunders Elseiver, 2011;1552-77
  3. Alvin CP. Hipoglisemi. Harrison’s Principles of Internal Medicine Endokrinoloji Bölümü
  4. Basım, Editors, Kasper DL, Fauci AS, Longo DL, Braunwald E, Hauser SL, Jameson JL. Türkçe çeviri: Bereket A. Nobel Tıp Kitabevi, İstanbul. 2009;355-63
  5. Masharani U, Gitelman SE. Hypoglycemic Disorders. Greenspan’s Basic & Clinical Endocrinology. 8 th edition. Editors, Gardner DG, Shoback D. McGraw – Hill, USA. 2007;748-69
  6. Ross R. Atherosclerosis-an inflammatory disease. N Engl J Med 1999;340:115–26
  7. Libby P, Ridker PM, Maseri A. Inflammation and atherosclerosis. Circulation 2002;105:1135–43
  8. Wright RJ, Frier BM. Vascular disease and diabetes: is hypoglycaemia an aggravating factor? Diabetes Metab Res Rev 2008;24:353-63
  9. Schwartz NS, Clutter WE, Shah SD, et al. Glycemic thresholds for activation of glucose counterregulatory systems are higher than the threshold for symptoms. J Clin Invest 1987;79:777-81
  10. Yu H, Rifai N. High-sensitivity C-reactive protein and atherosclerosis: from theory to therapy. Clin Biochem 2000;33:601–10
  11. Persson J, Formgren J, Israelsson B, et al. Ultrasounddetermined intima-media thickness and atherosclerosis. Direct and indirect validation. Arterioscler Thromb 1994;14:261–4
  12. Schejbal V. Epicardial fatty tissue of the right ventricle--morphology, morphometry and functional significance. Pneumologie 1989;43:490–9
  13. Verhagen SN, Visseren FL. Perivascular adipose tissue as a cause of atherosclerosis. Atherosclerosis 2011;214:3–10
  14. Bachar GN, Dicker D, Kornowski R, et al. Epicardial adipose tissue as a predictor of coronary artery disease in asymptomatic subjects. Am J Cardiol 2012;110:534–8
  15. Gullu H, Erdogan D, Caliskan M, et al. Interrelationship between noninvasive predictors of atherosclerosis: transthoracic coronary flow reserve, flow-mediated dilation, carotid intima-media thickness, aortic stiffness, aortic distensibility, elastic modulus, and brachial artery diameter. Echocardiography 2006;23:835-42
  16. Rana O, Byrne CD, Kerr D, et al. Acute hypoglycemia decreases myocardial blood flow reserve in patients with type 1 diabetes mellitus and in healthy humans. Circulation 2011;124:1548-56
  17. Wei M, Gibbons LW, Mitchell TL, et a