Subjects underwent echocardiographic examination including EFT and IMT measurementusing transthoracic echocardiography.Results: Postprandial Reactive Hypoglycemia group were marked with higher high-sensitivity C-reactive protein levels (1.67±0.67vs. 1.20±0.52; p= 0.007), carotid intima media thickness (0.65±0.10 vs. 0.50±0.10; p
📌 3 Key Takeaways
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Objective & Hypothesis:Aim: Hypoglycemia is associated with excessive cardiovascular mortality because of the pro-inflammatory and pro-atherothromboticpathway stimulation.
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Key Findings & Data:This study aims to determinethe development of sub-clinic atherosclerosis in patients with postprandial reactive hypoglycemia by investigating thickness ofcarotid intima media and epicardial fat, and high-sensitivity C-reactive protein values and their relationships with each other.Material and Methods: 51 patients in total were included in the project, including 28 patients (37.50±10.82 years) who hadhypoglycemia symptoms and who had hypoglycemia during prolonged oral glucose tolerance test and 23 healthy adult volunteers(35.01±10.92 years) as a control group.
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Conclusion & Impact:Subjects underwent echocardiographic examination including EFT and IMT measurementusing transthoracic echocardiography.Results: Postprandial Reactive Hypoglycemia group were marked with higher high-sensitivity C-reactive protein levels (1.67±0.67vs. 1.20±0.52; p= 0.007), carotid intima media thickness (0.65±0.10 vs. 0.50±0.10; p
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters
Abstract
Aim: Hypoglycemia is associated with excessive cardiovascular mortality because of the pro-inflammatory and pro-atherothromboticpathway stimulation. Hypoglycemia is known to affect the development of sub-clinic atherosclerosis. This study aims to determinethe development of sub-clinic atherosclerosis in patients with postprandial reactive hypoglycemia by investigating thickness ofcarotid intima media and epicardial fat, and high-sensitivity C-reactive protein values and their relationships with each other.Material and Methods: 51 patients in total were included in the project, including 28 patients (37.50±10.82 years) who hadhypoglycemia symptoms and who had hypoglycemia during prolonged oral glucose tolerance test and 23 healthy adult volunteers(35.01±10.92 years) as a control group. Subjects underwent echocardiographic examination including EFT and IMT measurementusing transthoracic echocardiography.Results: Postprandial Reactive Hypoglycemia group were marked with higher high-sensitivity C-reactive protein levels (1.67±0.67vs. 1.20±0.52; p= 0.007), carotid intima media thickness (0.65±0.10 vs. 0.50±0.10; p
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Cite This Article
TUĞCU, A. U., ÇİFTÇİ, F. C., ÇİFTÇİ, Ö. (2022). Sub-clinic atherosclerosis in patients with postprandial reactive hypoglycemia. Annals of Medical Research, Cilt: 26 - Sayı: 12, 2941–2947. https://ajindex.com/articles/446805
Hipoglisemi.Endokrinoloji 2011 Edition, Çetinkalp Ş. Ege Üniversitesi Basımevi, İzmir. 2011;289-94
CryerPE. Hypoglycemia. Williams Textbook of Endocrinology. 12 th edition, Editors, Melmed S, Polonsky KS,Larsen PR, Kronenberg HM, USA. Saunders Elseiver, 2011;1552-77
Alvin CP. Hipoglisemi. Harrison’s Principles of Internal Medicine Endokrinoloji Bölümü
Basım, Editors, Kasper DL, Fauci AS, Longo DL, Braunwald E, Hauser SL, Jameson JL. Türkçe çeviri: Bereket A. Nobel Tıp Kitabevi, İstanbul. 2009;355-63
Masharani U, Gitelman SE. Hypoglycemic Disorders. Greenspan’s Basic & Clinical Endocrinology. 8 th edition. Editors, Gardner DG, Shoback D. McGraw – Hill, USA. 2007;748-69
Ross R. Atherosclerosis-an inflammatory disease. N Engl J Med 1999;340:115–26
Libby P, Ridker PM, Maseri A. Inflammation and atherosclerosis. Circulation 2002;105:1135–43
Wright RJ, Frier BM. Vascular disease and diabetes: is hypoglycaemia an aggravating factor? Diabetes Metab Res Rev 2008;24:353-63
Schwartz NS, Clutter WE, Shah SD, et al. Glycemic thresholds for activation of glucose counterregulatory systems are higher than the threshold for symptoms. J Clin Invest 1987;79:777-81
Yu H, Rifai N. High-sensitivity C-reactive protein and atherosclerosis: from theory to therapy. Clin Biochem 2000;33:601–10
Persson J, Formgren J, Israelsson B, et al. Ultrasounddetermined intima-media thickness and atherosclerosis. Direct and indirect validation. Arterioscler Thromb 1994;14:261–4
Schejbal V. Epicardial fatty tissue of the right ventricle--morphology, morphometry and functional significance. Pneumologie 1989;43:490–9
Verhagen SN, Visseren FL. Perivascular adipose tissue as a cause of atherosclerosis. Atherosclerosis 2011;214:3–10
Bachar GN, Dicker D, Kornowski R, et al. Epicardial adipose tissue as a predictor of coronary artery disease in asymptomatic subjects. Am J Cardiol 2012;110:534–8
Gullu H, Erdogan D, Caliskan M, et al. Interrelationship between noninvasive predictors of atherosclerosis: transthoracic coronary flow reserve, flow-mediated dilation, carotid intima-media thickness, aortic stiffness, aortic distensibility, elastic modulus, and brachial artery diameter. Echocardiography 2006;23:835-42
Rana O, Byrne CD, Kerr D, et al. Acute hypoglycemia decreases myocardial blood flow reserve in patients with type 1 diabetes mellitus and in healthy humans. Circulation 2011;124:1548-56