Journals / Annals of Medical Research / 2019 / Cilt: 26 - Sayı: 4

The predictive value of platelet to lymphocyte ratio for procedural complications and mid-term mortality in aortic stenosis patients who underwent a transcatheter aortic valve implantation

Pages
537–541
Publication Date
2022-10-12
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Of note, serum PLR level was significantly elevated in patients who developed vascular complication and stroke after the TAVI (p

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Aim: Calcific aortic valve disease is an active cellular process including chronic inflammation, calcification, and lipid accumulation which issimilar to atherosclerosis.
📊
Key Findings & Data:The platelet to lymphocyte ratio (PLR) is a hematologicalparameter which increases with the inflammation and vascular oxidative stress.
💡
Conclusion & Impact:Of note, serum PLR level was significantly elevated in patients who developed vascular complication and stroke after the TAVI (p
🔬Design:Research Article
📍Scope:2012 Verileri
⚙️Variables:Domain Parameters

Abstract

Aim: Calcific aortic valve disease is an active cellular process including chronic inflammation, calcification, and lipid accumulation which issimilar to atherosclerosis. The platelet to lymphocyte ratio (PLR) is a hematologicalparameter which increases with the inflammation and vascular oxidative stress. In the present study, we aimed to evaluate whether the PLR had a prognostic role inprocedural complications and mid-term mortality ofaortic stenosis (AS) patients underwent transcatheter aortic valve implantation (TAVI).Material and Methods: A total of 100 symptomatic severe AS patients undergone TAVI in atertiary heart center between June 2012 and June 2016 were retrospectively analyzed. The PLR was calculated by dividing the absolute platelet count by the absolute lymphocyte count before the TAVI procedure. The follow-up duration of the study was six months.Results: The mean age of study population was 78 years (range: 65-85), and 35 patients were male. Of note, serum PLR level was significantly elevated in patients who developed vascular complication and stroke after the TAVI (p

🔖

Cite This Article

GÜRBAK, İ., GULER, A., ÇINAR, T., TOSU, A. R., KAHRAMAN, S. (2022). The predictive value of platelet to lymphocyte ratio for procedural complications and mid-term mortality in aortic stenosis patients who underwent a transcatheter aortic valve implantation. Annals of Medical Research, Cilt: 26 - Sayı: 4, 537–541. https://ajindex.com/articles/446792

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (13)

  1. Tziomalos K, Athyros VG, Karagiannis A, et al. Established and emerging vascular risk factors and the development of aortic stenosis: an opportunity for prevention? Expert Opin Ther Targets 2008;12:809-20
  2. Lindroos M, Kupari M, Heikkila J, et al. Prevalence of aortic valve abnormalities in the elderly: an echocardiographic study of a random population sample. J Am Coll Cardiol 1993;21:1220-5
  3. Carabello BA, Paulus WJ. Aortic stenosis. Lancet. 2009;373:956-66
  4. Rajamannan NM, Evans FJ, Aikawa E, et al. Calcific aortic valve disease:not simply a degenerative process: a review and agenda for research from the National Heart and Lung and Blood Institute Aortic Stenosis Working Group. Executive summary: calcific aortic valve disease-2011 update. Circulation 2011;124:1783-91
  5. Cagirci G, Cay S, Canga A, et al. Association between plasma asymmetrical dimethylarginine activity and severity of aortic valve stenosis. J Cardiovasc Med (Hagerstown) 2011;12:96-101
  6. Otto CM, Kuusisto J, Reichenbach DD, et al. Characterization of the early lesion of ‘degenerative’ valvular aortic stenosis: histological and immune histochemical studies. Circulation 1994;90:844-53
  7. Wada S, Sugioka K, Naruko T, et al. Relationship between oxidative stress and aortic valve stenosis in humans: an immunohistochemical study. Osaka City Med J 2013;9:61-7
  8. Coté N, Mahmut A, Bosse Y, et al. Inflammation is associated with the remodeling of calcificaortic valve disease. Inflammation 2013; 36:573-81
  9. Ghaisas NK, Foley JB, O’Briain DS, et al. Adhesion molecules in nonrheumatic aortic valve disease: endothelial expression, serum levels and effects of valve replacement. J Am Coll Cardiol 2000;36:2257-62
  10. Poggianti E, Venneri L, Chubuchny V, et al. Aortic valve sclerosis is associated with systemic endothelial dysfunction. J Am Coll Cardiol 2003;41:136-41
  11. Miller JD, Chu Y, Brooks RM, et al. Dysregulation of antioxidant mechanisms contributes to increased oxidative stress in calcific aortic valvular stenosis in humans. J Am Coll Cardiol 2008;52:843-50
  12. Kaya H, Ertas F, Islamoglu Y, et al. Association between neutrophil to lymphocyte ratio and severity of coronary artery disease. Clin Appl Thromb Hemost 2014;20.50-4
  13. Sen N, Afsar B, Ozcan F, et al. The neutrophil to lymphocyte ratio was associated with impaired myocardial perfusion and long term adverse outcome in patients with ST-elevated myocardial infarction undergoing primary coronary intervention. Atherosclero