SavedAdd your journal

Journals / Annals of Medical Research / 2019 / Cilt: 26 - Sayı: 7

The relationship of pelvic pain symptoms with CA-125 levels in endometriosis cases

Pervin KARLI
Pages
1326–1329
Publication Date
2022-10-12
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

In light of the results, preoperative serum CA-125 levels are a predictor and should be considered for patients withchronic pelvic pain.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Aim: This study aims to investigate the relationship between CA-125 levels and pelvic pain symptoms in patients with endometriosis.Material and Methods: This study consisted of retrospective data of 31 patients who were admitted to the outpatient clinic ofFaculty of Medicine, Amasya University between 01 January 2013 and 01 January 2018 for complaints of pelvic pain, dysmenorrheaor infertility, who had a preliminary diagnosis of endometriosis by clinical and ultrasonography examination and diagnosedwith endometriosis by laparoscopy or laparotomy as well as 35 patients who received diagnostic laparoscopy for any reason orlaparotomy or laparoscopy for benign or tubal ligation.
📊
Key Findings & Data:The study included patients aged 18 to 45 years old.
💡
Conclusion & Impact:In light of the results, preoperative serum CA-125 levels are a predictor and should be considered for patients withchronic pelvic pain.
🔬Design:Research Article
📍Scope:2013 Verileri
⚙️Variables:Domain Parameters

Abstract

Aim: This study aims to investigate the relationship between CA-125 levels and pelvic pain symptoms in patients with endometriosis.Material and Methods: This study consisted of retrospective data of 31 patients who were admitted to the outpatient clinic ofFaculty of Medicine, Amasya University between 01 January 2013 and 01 January 2018 for complaints of pelvic pain, dysmenorrheaor infertility, who had a preliminary diagnosis of endometriosis by clinical and ultrasonography examination and diagnosedwith endometriosis by laparoscopy or laparotomy as well as 35 patients who received diagnostic laparoscopy for any reason orlaparotomy or laparoscopy for benign or tubal ligation. The study included patients aged 18 to 45 years old. Patient data wererecorded via an information form which included age, presence of infertility, duration of infertility, preoperative CA-125 values,presence of dysmenorrhea and dyspareunia symptoms, previous operation for endometriosis, presence of additional gynecologicalpathology, disease stage, operation notes, primary complaints, preoperative TVS information, gravida, parity, abortion and livingchildren, used medication, if any, chronical diseases, if any.Results: The blood CA-125 levels were statistically significant in the patients considering the presence of chronic pelvic pain,dysmenorrhea and infertility (p < 0.05). Mean CA-125 levels were 51.43 U/ml in patients with chronic pelvic pain symptoms. MeanCA-125 levels were 45.45 (U/ml) in patients with dysmenorrhea. Mean CA-125 was 45.67 (U/ml) in infertile patients and 45.58 (U/ml) in patients with endometriosis. Mean CA-125 levels in patients with additional gynecological diseases were 38.29 (U/ml), whichwas not statistically significant.Conclusion: This study demonstrated that CA-125 levels were significantly associated with pelvic pain symptoms, infertility andendometriosis. In light of the results, preoperative serum CA-125 levels are a predictor and should be considered for patients withchronic pelvic pain.

🔖

Cite This Article

KARLI, P. (2022). The relationship of pelvic pain symptoms with CA-125 levels in endometriosis cases. Annals of Medical Research, Cilt: 26 - Sayı: 7, 1326–1329. https://ajindex.com/articles/446706

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (15)

  1. Hirsch M, Duffy JMN, Kusznir JO, et al. International Collaboration to Harmonize Outcomes and Measures for Endometriosis. Variation in outcome reporting in endometriosis trials: a systematic review. Am J Obstet Gynecol 2016;214:452- 64
  2. Sangi-Haghpeykar H, Poindexter AN. Epidemiology of endometriosis among parous women. Obstet Gynecol 1995;856:983-92
  3. Chatman DL, Ward AB. Endometriosis in adolescents. J Reprod Med 1982;273:156-60
  4. Missmer SA, Hankinson SE, Spiegelman D, et al. Incidence of laparoscopically confirmed endometriosis by demographic, anthropometric, and lifestyle factors. Am J Epidemiol 2004;160:784-96
  5. Sinaii N, Plumb K, Cotton L, et al. Differences in characteristics among 1,000 women with endometriosis based on extent of disease. Fertil Steril 2008 89:538-45
  6. Kennedy S, Bergqvist A, Chapron C, et al. ESHRE guideline for the diagnosis and treatment of endometriosis. Hum Reprod 2005;20:2698-704
  7. Lebovic DI, Mueller MD, Taylor RN. Immunobiology of endometriosis. Fertil Steril 2001;75:1-10
  8. Van Langendonckt A, Casanas-Roux F, Donnez J. Oxidative stress and peritoneal endometriosis. Fertil Steril 2002;77:861-70 9. Harada T, Iwabe T, Terakawa N. Role of cytokines in endometriosis. Fertil Steril 2001;76:1-10
  9. Eyster KM, Klinkova O, Kennedy V, et al. Whole genome deoxyribonucleic acid microarray analysis of gene expression in ectopic versus eutopic endometrium. Fertil Steril 2007;88:1505-33
  10. Aflatoonian A, Rahmani E, Rahsepar M. Assessing the efficacy of aspiration and ethanol injection in recurrent endometrioma before IVF cycle: A randomized Clinical Trial. Iran J Reprod Med 2013;11:179-84
  11. Koninckx PR, Kennedy SH, Barlow DH. Endometriotic disease: the role of peritoneal fluid. Hum Reprod Update. 1998;4:741-51
  12. Simpson JL, Elias S, Malinak LR, et al. Heritable aspects of endometriosis. I. Genetic studies. Am J Obstet Gynecol 1980;137:327-31
  13. Güney G, Tokmak A, Güzel Aİ, et al. Does IVF-ET Procedure Increase the Pregnancy Rates in Women Underwent Laparoscopic Endometriosis Surgery? Gynecol Obstet Reprod Med 2015;21:75-80 15. Uppal T, Amarasekara C, Kaushik V. Chronic pelvic pain. Australas J Ultrasound Med 2011;14:24-7
  14. Amaral VF, Ferriani RA, Sá MF, et al. Positive correlation between serum and peritoneal fluid CA-125 levels in women with pelvic endometriosis. Sao Paulo Med J 2006;124:223- 7
  15. Karimi-Zarchi M, Dehshiri-Zadeh N, Sekhavat L, et al. Correlation of CA-125 serum level and clinico-pathol