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Journals / Annals of Medical Research / 2019 / Cilt: 26 - Sayı: 11

The role of Crocin in an acrylamide-induced neurotoxicity model in Wistar rats

Mehmet Erman ERDEMLİ
Harika Gözde GÖZÜKARA BAĞ
Zeynep ERDEMLİ
Eyüp ALTINÖZ
Pages
2540–2544
Publication Date
2022-10-12
DOI
—
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It was observed that oral AAadministration altered the antioxidant/oxidant balance favoring the oxidants in male rat brain tissues, leading to oxidative stressinduced neurotoxicity, while Cr administration reestablished the normal antioxidant/oxidant balance, preventing the oxidative stressinduced neurotoxicity via detoxification.Conclusion: The present study concluded that the administered Cr dose was sufficient to prevent neurotoxicity and we recommendthat adequate amounts of Cr should be consumed to prevent AA-induced toxicity and improve antioxidant capacity.

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Objective & Hypothesis:Aim: The changes in rat brain tissues treated with Crocin (Cr) as a protective agent in an acrylamide (AA) neurotoxicity model wereinvestigated.Material and Methods: The present with of the experimental animal ethics committee at Inonu University, Faculty of Medicine (2016/ A-59).
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Key Findings & Data:Forty male rats were randomly divided into 4 groups with study was conducted the approval equal number of rats (10):Control, Cr, AA, Cr + AA Groups.
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Conclusion & Impact:It was observed that oral AAadministration altered the antioxidant/oxidant balance favoring the oxidants in male rat brain tissues, leading to oxidative stressinduced neurotoxicity, while Cr administration reestablished the normal antioxidant/oxidant balance, preventing the oxidative stressinduced neurotoxicity via detoxification.Conclusion: The present study concluded that the administered Cr dose was sufficient to prevent neurotoxicity and we recommendthat adequate amounts of Cr should be consumed to prevent AA-induced toxicity and improve antioxidant capacity.
🔬Design:Modeling & Simulation
📍Scope:2016 Verileri
⚙️Variables:Domain Parameters

Abstract

Aim: The changes in rat brain tissues treated with Crocin (Cr) as a protective agent in an acrylamide (AA) neurotoxicity model wereinvestigated.Material and Methods: The present with of the experimental animal ethics committee at Inonu University, Faculty of Medicine (2016/ A-59). Forty male rats were randomly divided into 4 groups with study was conducted the approval equal number of rats (10):Control, Cr, AA, Cr + AA Groups. Malondialdehyde (MDA), reduced glutathione (GSH), total antioxidant status (TAS), total oxidantstatus (TOS), Oxidative stress index (OSI), superoxide dismutase (SOD), catalase (CAT) and protein values were examined in thebrain tissues.Results: MDA, TOS and OSI levels increased in brain tissues of AA administered rats when compared to the other groups, whilethe GSH, TAS, SOD and CAT levels decreased in the group (p < 0.05). GSH, TAS, SOD and CAT levels increased, but MDA, TOS andOSI levels decreased in the AA + Cr administered group when compared to the AA group (p < 0.05). It was observed that oral AAadministration altered the antioxidant/oxidant balance favoring the oxidants in male rat brain tissues, leading to oxidative stressinduced neurotoxicity, while Cr administration reestablished the normal antioxidant/oxidant balance, preventing the oxidative stressinduced neurotoxicity via detoxification.Conclusion: The present study concluded that the administered Cr dose was sufficient to prevent neurotoxicity and we recommendthat adequate amounts of Cr should be consumed to prevent AA-induced toxicity and improve antioxidant capacity.

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Cite This Article

ERDEMLİ, M. E., BAĞ, H. G. G., ERDEMLİ, Z., ALTINÖZ, E. (2022). The role of Crocin in an acrylamide-induced neurotoxicity model in Wistar rats. Annals of Medical Research, Cilt: 26 - Sayı: 11, 2540–2544. https://ajindex.com/articles/446649

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