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Journals / Annals of Medical Research / 2019 / Cilt: 26 - Sayı: 2

Molsidomine (MOL) reduces postoperative pelvic adhesion: A rat uterine horn model

Işıl KÖLELİ
Bahar SARIİBRAHİM
Onural OZHAN
Lale BAKIR
Ercan YILMAZ
Kevser TANBEK
Hakan PARLAKPİNAR
Nurhan SAHİN
Pages
260–264
Publication Date
2022-10-12
DOI
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Adhesion scores were evaluated using macroscopic, microscopic, and immunohistochemical grading 14 days postoperatively.Results:The Majuzi adhesion score of the rats in the MOL group [1 (0-4)] was lower than the score of the rats in the sham [4 (2-5)] and Seprafilm [4 (1-5)] (p

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Objective & Hypothesis:Aim: Postoperative pelvic adhesions (PPAs) are a common complication that leads to many problems.
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Key Findings & Data:This study aimed to compare the role of Seprafilm (a protective barrier), and molsidomine (MOL), recognized for its antioxidative and antiproliferative effects, in preventing pelvic adhesion.Material and Methods: A total of 30 of female Wistar albino rats were randomly divided into 3 groups.
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Conclusion & Impact:Adhesion scores were evaluated using macroscopic, microscopic, and immunohistochemical grading 14 days postoperatively.Results:The Majuzi adhesion score of the rats in the MOL group [1 (0-4)] was lower than the score of the rats in the sham [4 (2-5)] and Seprafilm [4 (1-5)] (p
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Aim: Postoperative pelvic adhesions (PPAs) are a common complication that leads to many problems. This study aimed to compare the role of Seprafilm (a protective barrier), and molsidomine (MOL), recognized for its antioxidative and antiproliferative effects, in preventing pelvic adhesion.Material and Methods: A total of 30 of female Wistar albino rats were randomly divided into 3 groups. They underwent bilateral uterine horn injury. The rats in the Sham group (n=10) received no special treatment. The rats in the Seprafilm group (n=10) were treated withSeprafilm. The rats in the MOL group (n=10) received 10 mg/kg MOL orally for 14 days. Adhesion scores were evaluated using macroscopic, microscopic, and immunohistochemical grading 14 days postoperatively.Results:The Majuzi adhesion score of the rats in the MOL group [1 (0-4)] was lower than the score of the rats in the sham [4 (2-5)] and Seprafilm [4 (1-5)] (p

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Cite This Article

KÖLELİ, I., SARIİBRAHİM, B., OZHAN, O., BAKIR, L., YILMAZ, E., TANBEK, K., PARLAKPİNAR, H., SAHİN, N. (2022). Molsidomine (MOL) reduces postoperative pelvic adhesion: A rat uterine horn model. Annals of Medical Research, Cilt: 26 - Sayı: 2, 260–264. https://ajindex.com/articles/446640

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References (17)

  1. Drollette CM, Badawy SZ. Pathophysiology of pelvic adhesions. modern trends in preventing infertility. J Reprod Med 1992;37:107-21
  2. Ivarsson ML, Holmdahl L, Franzén G, et al. Cost of bowel obstruction resulting from adhesions. Eur J Surg 1997;163:679-84
  3. Ray NF, Denton WG, Thamer M, et al. Abdominal Adhesiolysis: Inpatient Care and Expenditures in the United States in 1994. J Am Coll Surg 1998;186:1-9
  4. Arung W, Meurisse M, Detry O. Pathophysiology and prevention of postoperative peritoneal adhesions. World J Gastroenterol 2011;17:4545
  5. Koninckx PR, Gomel V. Introduction. quality of pelvic surgery and postoperative adhesions fertilsteril 2016;106:991-3
  6. Polat N, Ozer MA, Parlakpinar H, et al. Effects of molsidomine on retinal ischemia/reperfusion injury in rabbits. Biotech Histochem 2018;93:188-97
  7. Durak MA, Parlakpinar H, Polat A, et al. Protective and therapeutic effects of molsidomine on radiation induced neural injury in rats Biotech Histochem 2017;92:68-77
  8. Singh RJ, Hogg N, Joseph J, et al. The peroxynitrite generator, sin-1, becomes a nitric oxide donor in the presence of electron acceptors. arch biochembiophys 1999;361:331-9
  9. Gupta A, Sharma S, Chopra K. Reversal of iron-induced nephrotoxicity in rats by molsidomine, a nitric oxide donor. Food ChemToxicol 2008;46:537-43
  10. Walder CE, Thiemermann C, Vane JR. The involvement of endothelium-derived relaxing factor in the regulation of renal cortical blood flow in the rat. Br J Pharmacol 1991;102:967-73
  11. Kalouda T, Pitsikas N. The nitric oxide donor molsidomine induces anxiolytic-like behaviour in two different rat models of anxiety. Pharmacol Biochem Behav 2015;138:111-6
  12. Lee JH, Go AK, Oh SH, et al. Tissue anti-adhesion potential of ibuprofen-loaded PLLA–PEG diblock copolymer films. Biomaterials 2005;26:671-8
  13. Shahram E, Sadraie SH, Kaka G, et al. Evaluation of chitosan–gelatin films for use as postoperative adhesion barrier in rat cecum model. Int J Surg 2013;11:1097-102
  14. Karatas A, Ozlu T, Ozyalvacli G, et al. Intraperitoneal nigella sativa for prevention of postoperative intra-abdominal adhesions in rats. J Invest Surg 2014;27:319-26
  15. Mazujı Mk, Kalambahetı K, Pawar B. Prevention of Adhesions With Polyvinylpyrrolidone. Arch Surg 1964;89:1011-5
  16. Sun Y, Oberley LW, Li Y. A simple method for clinical assay of superoxide dismutase. Clin Chem 1988;34:497-500
  17. Durak I, Akyol O, Es MU, et al. Element structure in stenotic mitral valves. Am J Cardiol