Journals / Annals of Medical Research / 2020 / Cilt: 27 - Sayı: 8

The high rate of Candida parapsilosis candidemia among non-burn patients with polytrauma in the surgical intensive care units of a university hospital

Pages
2088–2093
Publication Date
2022-10-12
DOI
—
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⚡ TL;DR(Too Long; Didn't Read)

However, since our study wasobservational and limited to such a small number of patients, the results obtained should be applied with caution.

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Objective & Hypothesis:Aim: Candidemia is a life-threatening infection that has been reported to be associated with poorer outcomes in trauma patients.The present study aimed to investigate the epidemiology of candidemia in non-burn patients with polytrauma.Material and Methods: We conducted a retrospective, single-center, observational study of polytrauma patients with candidemiaadmitted to the surgical intensive care units of a university hospital in Turkey between 2013 and 2017 on.Results: The incidence of candidemia was 127 episodes per 1000 intensive care unit admissions in polytrauma patients.
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Key Findings & Data:Nonalbicans Candida species accounted for 75.5% of all candidemia episodes.
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Conclusion & Impact:However, since our study wasobservational and limited to such a small number of patients, the results obtained should be applied with caution.
🔬Design:Research Article
📍Scope:2013 Verileri
⚙️Variables:Domain Parameters

Abstract

Aim: Candidemia is a life-threatening infection that has been reported to be associated with poorer outcomes in trauma patients.The present study aimed to investigate the epidemiology of candidemia in non-burn patients with polytrauma.Material and Methods: We conducted a retrospective, single-center, observational study of polytrauma patients with candidemiaadmitted to the surgical intensive care units of a university hospital in Turkey between 2013 and 2017 on.Results: The incidence of candidemia was 127 episodes per 1000 intensive care unit admissions in polytrauma patients. Nonalbicans Candida species accounted for 75.5% of all candidemia episodes. C. parapsilosis (51.05%) was the predominant species,followed by C. albicans (24.52%) and C. tropicalis (12.21%). The highest crude mortality rate (72%) was observed in patients with C.parapsilosis candidemia. In multivariate analyses, who had undergone prior gastrointestinal surgery were 7.1 times more likely tohave C. parapsilosis candidemia than those with other strains.Conclusion: Our study, remarkable, demonstrated a high incidence of Candidemia had in polytrauma patients, and non-albicansCandida species were the most frequently isolated candida species. According to our study findings, a prior history of gastrointestinalsurgery may help predict C. parapsilosis, as the causative agent of candidemia in polytrauma patients. However, since our study wasobservational and limited to such a small number of patients, the results obtained should be applied with caution.

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Cite This Article

BAL, T., ÇABALAK, M., ÖZER, B., ÇÖMEZ, M. S., ÖNLEN, Y. (2022). The high rate of Candida parapsilosis candidemia among non-burn patients with polytrauma in the surgical intensive care units of a university hospital. Annals of Medical Research, Cilt: 27 - Sayı: 8, 2088–2093. https://ajindex.com/articles/446587

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References (17)

  1. Krug EG, Sharma GK, Lozano R. The global burden of injuries. Am J Public Health 2000;90:523–26
  2. Moran CG, Lecky F, Bouamra O, et al. Changing the system - major trauma patients and their outcomes in the NHS (England) 2008-17. EClinicalMedicine 2018;2-3:13-21
  3. Kourkoumpetis T, Manolakaki D, Velmahos G, et al. Candida infection and colonization among nontrauma emergency surgery patients. Virulence 2010;1:359-66
  4. Thompson KB, Krispinsky LT, Stark RJ. Late immune consequences of combat trauma: a review of traumarelated immune dysfunction and potential therapies. Mil Med Res 2019;6:11
  5. Rau CS, Wu SC, Kuo PJ, et al. Polytrauma defined by the New Berlin definition: a validation test based on propensity-score matching approach. Int J Environ Res Public Health 2017;14. pii:E1045
  6. Pappas PG, Lionakis MS, Arendrup MC, et al. Invasive candidiasis. Nat Rev Dis Primers. 2018;4:18026
  7. Hankovszky P, Tarsy D, Öveges N, et al. Invasive candida infections in the ICU: diagnosis and therapy. J Crit Care Med (Targu Mures). 2015;1:129-39
  8. Mellinghoff SC, Cornely OA, Jung N. Essentials in Candida bloodstream infection. Infection 2018;46:897-9
  9. Pfaller MA, Diekema DJ, Turnidge JD, et al. Twenty years of the SENTRY antifungal surveillance program: results for Candida species from 1997-2016. Open Forum Infect Dis 2019;6:S79-S94
  10. Pappas PG, Kauffman CA, Andes DR, et al. Clinical practise guideline for the management of candidiasis: 2016 update by the Infectious Disease Society of America. Clin Infect Dis 2016;62:e1-50
  11. Kauffmann CA. Overview of Candida infections. Marr KA, ed. UpToDate. Waltham, MA: UpToDate Inc. https://www.uptodate.com accessed date January 02, 2019)
  12. Pedrosa AF, Rodrigues AG. Candidemia in burn patients: figures and facts. J Trauma 2011;70:498- 506
  13. Singh RI, Xess I, Mathur P, et al. Epidemiology of candidaemia in critically ill trauma patients: experiences of a level I trauma centre in North India. J Med Microbiol 2011;60(Pt 3):342-8
  14. Tak V, Mathur P, Varghese P, et al. The epidemiological profile of candidemia at an Indian trauma care centre. J Lab Physicians 2014;6:96-101
  15. Borzotta AP, Beardsley K. Candida infections in critically ill trauma patients: a retrospective casecontrol study. Arch Surg 1999;134:657-64
  16. Tukenmez Tigen E, Bilgin H, Perk Gurun H, et al. Risk factors, characteristics, and outcomes of candidemia in an adult intensive care unit in Turkey. Am J Infect Control 2017;45:e61-3
  17. Gonzalez