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Journals / Annals of Medical Research / 2020 / Cilt: 27 - Sayı: 8

Dynamic thiol / disulfide homeostasis in metabolically healthy obese adolescents

Özcan EREL
Özge YÜCE
Pages
2186–2190
Publication Date
2022-10-12
DOI
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Disulfide to native thiol ratio (SS/SH), disulfide to total thiol ratio(SS/(SH+SS)), and native thiol to total thiolratio (SH/(SH + SS)) were calculated and were presented as percentage.Results: Native and total thiol levels-as an antioxidative parameter-was significantly higher in obese adolescents compared tohealthy-weight adolescents (p

📌 3 Key Takeaways

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Objective & Hypothesis:Aim: This study aim to discuss the possible role of oxidant-antioxidant balance in providing metabolic health in obese adolescentsby determining the oxidant-antioxidant status.Material and Methods: 98 metabolically healthy obese and 75 normal-weight adolescents participated in the study.
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Key Findings & Data:Obeseindividuals were grouped according to the severity of obesity.
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Conclusion & Impact:Disulfide to native thiol ratio (SS/SH), disulfide to total thiol ratio(SS/(SH+SS)), and native thiol to total thiolratio (SH/(SH + SS)) were calculated and were presented as percentage.Results: Native and total thiol levels-as an antioxidative parameter-was significantly higher in obese adolescents compared tohealthy-weight adolescents (p
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Aim: This study aim to discuss the possible role of oxidant-antioxidant balance in providing metabolic health in obese adolescentsby determining the oxidant-antioxidant status.Material and Methods: 98 metabolically healthy obese and 75 normal-weight adolescents participated in the study. Obeseindividuals were grouped according to the severity of obesity. Biochemical parameters including thiol/ disulfide homeostasis wereanalyzed. Serum native thiol (SH), total thiol (SH+SS) and disulfide (SS) concentrations were determined using a novel automatedmeasurement method. Disulfide to native thiol ratio (SS/SH), disulfide to total thiol ratio(SS/(SH+SS)), and native thiol to total thiolratio (SH/(SH + SS)) were calculated and were presented as percentage.Results: Native and total thiol levels-as an antioxidative parameter-was significantly higher in obese adolescents compared tohealthy-weight adolescents (p

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Cite This Article

EREL, Ö., YÜCE, Ö. (2022). Dynamic thiol / disulfide homeostasis in metabolically healthy obese adolescents. Annals of Medical Research, Cilt: 27 - Sayı: 8, 2186–2190. https://ajindex.com/articles/446440

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References (17)

  1. WHO, World Health Organization: www.who.int/ mediacentre/factsheets/fs311/en/(2016)
  2. Manna P, Jain SK. Obesity, oxidative stress, adipose tissue dysfunction, and the associated health risks: causes and therapeutic strategies. Metab Syndr Relat Disord 2015;13:423-4
  3. Stefan N, Kantartzis K, Machann J, et al. Identification and charac-terization of metabolically benign obesity in humans. Arch Intern Med 2008;168:1609-16
  4. Phillips CM. Metabolically healthy obesity: definitions, determinants and clinical implications. Rev Endocr Metab Disord 2013;14:219-27
  5. Cremers CM, Jakob U: Oxidant sensing by reversible disulphide bond formation. J Biol Chem 2013;288:26489–96
  6. Dense SM. Thiol based antioxidants. Curt Top Cell Regul 2000;36:151-80
  7. Biswas S, Chida AS, Rahman I. Redox modifications of protein-thiols: emerging roles in cell signal-ing. Biochem Pharmacol 2006;71:551-64
  8. Circu ML, Aw TY. Reactive oxygen species, cellular redox systems, and apoptosis. Free Radic Biol Med 2010;48:749-62
  9. Kelly AS, Barlow SE, Rao G, et al. Severe obesity in children and adolescents: identification, associated health risks,and treatment approaches: a scientific state-ment from the American Heart Association. Circulation 2013;128:1689-712
  10. Flegal KM, Wei R, Ogden CL, et al. Characterizing extreme values of body mass index-for-age by using the 2000 Centers for Disease Control and Prevention growth charts. Am J Clin Nutr 2009;90:1314-20
  11. Phillips CM. Metabolically healthy obesity: definitions, determinants and clinical implications. Rev Endocr Metab Disord 2013;14:219-27
  12. Daniels SR, Greer FR; Committee on Nutrition. Lipid screening and cardiovascular health in child-hood. Pediatrics 2008;122:198-208
  13. Sinha R, Fisch G, Teague B, et al. Prevalence of impaired glucose tolerance among children and adolescents with marked obesity. N Engl J Med 2002;346:802–10
  14. Keskin M, Kurtoglu S, Kendirci M, et al. Homeostasis model assessment is more reliable than the fasting glucose/insulin ratio and quantitative insulin sensitivity check index for as-sessing insulin resistance among obese children and adolescents. Pediatrics. 2005;115:e500-3
  15. Erel O, Neselioglu S: A novel and automated assay for thiol/disulphide homeostasis. Clin Biochem 2014;47:326–32
  16. Inzaugarat ME, Billordo LA, Vodanovich F, et al. Alterations in innate and adaptive immune leukocytes are involved in paediatric obesity. Pediatr Obes 2014;9:381-90
  17. Burke V. Obesity in childho