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Journals / Annals of Medical Research / 2020 / Cilt: 27 - Sayı: 2

Relationship between T regulatory cell levels (CD4 + CD25 + CD127- T cells) and the presence of autoantibodies in adult patients with selective IgA deficiency

Gökhan AYTEKİN
Eray YILDIZ
Osman YAŞKIRAN
Esra YAŞKIRAN
Şeyma ÇELİKBİLEK ÇELİK
Fatih ÇÖLKESEN
Sevgi KELEŞ
Recep TUNÇ
Pages
538–544
Publication Date
2022-10-12
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Further studiesare required to shed light on this issue in order to evaluate more patients with sIgA deficiency with autoimmunity

📌 3 Key Takeaways

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Objective & Hypothesis:Aim: Selective immunoglobulin A (sIgA) deficiency is the most common primary immunodeficiency.
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Key Findings & Data:Regulatory Tcells (T reg) are a group of cells that play a key role in preventing autoimmunity.Material and Methods: 28 patients with selective IgA deficiency and a control group consisting of 15 individuals of similar age andsex were included in the study.Results: Serum IgA levels were lower in patients with sIgA deficiency (p < 0.001).
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Conclusion & Impact:Further studiesare required to shed light on this issue in order to evaluate more patients with sIgA deficiency with autoimmunity
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Aim: Selective immunoglobulin A (sIgA) deficiency is the most common primary immunodeficiency. Individuals with selective IgAdeficiency are generally considered to be asymptomatic. In some patients, autoimmune diseases have been reported. Regulatory Tcells (T reg) are a group of cells that play a key role in preventing autoimmunity.Material and Methods: 28 patients with selective IgA deficiency and a control group consisting of 15 individuals of similar age andsex were included in the study.Results: Serum IgA levels were lower in patients with sIgA deficiency (p < 0.001). There was no difference between the two groups interm of the rate of Treg cells (p: 0.562 and p: 0.873). There was at least one autoantibody positivity in 19 (67.8%) patients with sIgAdeficiency and 4 (26.7%) in the control group. The most common positive autoantibody was ANA in both groups. Serum IgG andIgG1 levels were significantly higher in sIgA deficiency patients with autoantibody than in the other group (p: 0.004 and p: 0.004) Therelationship between presence of autoantibodies and Treg cell levels in patients with sIgA deficiency was not statistically significant(p: 0.199). The regression analysis showed that the IgG level (OR: 1.594, 95% CI: 1.096-2.319, p: 0.015) was an independent predictorfor the presence of autoantibodies.Conclusion: The findings of our study are important as they are the first evaluation in adult sIgA deficient patients. Further studiesare required to shed light on this issue in order to evaluate more patients with sIgA deficiency with autoimmunity

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Cite This Article

AYTEKİN, G., YILDIZ, E., YAŞKIRAN, O., YAŞKIRAN, E., ÇELİK, Ş. Ç., ÇÖLKESEN, F., KELEŞ, S., TUNÇ, R. (2022). Relationship between T regulatory cell levels (CD4 + CD25 + CD127- T cells) and the presence of autoantibodies in adult patients with selective IgA deficiency. Annals of Medical Research, Cilt: 27 - Sayı: 2, 538–544. https://ajindex.com/articles/446424

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