Phagocytic indices, cytokines and respiratory burst indices were correlated with plasma Zn levels using Spearmans Correlation analysis at P
📌 3 Key Takeaways
🎯
Objective & Hypothesis:Aim: To determine the relationship between Zinc levels with different aspects of innate immunity [percentage leucocyte migration (%LM), intracellular killing (%NBT), plasma inflammatory cytokines (IL-6) and IL-8), plasma antioxidant enzymes (catalase, superoxide dismutase, myeloperoxidase, hydrogen peroxide) and nitric oxide] among healthy Nigerians.
📊
Key Findings & Data:Material and Methods: In 50 healthy adults, two phagocytic indices [percentage leucocyte migration (%LM) and intracellular killing (%NBT)] were determined by microscopy; two inflammatory cytokines [Plasma interleukin 6 (IL-6) and 8 (IL-8)] were assessed using ELISA; respiratory burst indices [plasma catalase (CAT), superoxide dismutase (SOD), myeloperoxidase (MPO), hydrogen peroxide (H2 O2 ) and nitric oxide (NO)] were evaluated by spectrophotometry.
💡
Conclusion & Impact:Phagocytic indices, cytokines and respiratory burst indices were correlated with plasma Zn levels using Spearmans Correlation analysis at P
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters
Abstract
Aim: To determine the relationship between Zinc levels with different aspects of innate immunity [percentage leucocyte migration (%LM), intracellular killing (%NBT), plasma inflammatory cytokines (IL-6) and IL-8), plasma antioxidant enzymes (catalase, superoxide dismutase, myeloperoxidase, hydrogen peroxide) and nitric oxide] among healthy Nigerians. Material and Methods: In 50 healthy adults, two phagocytic indices [percentage leucocyte migration (%LM) and intracellular killing (%NBT)] were determined by microscopy; two inflammatory cytokines [Plasma interleukin 6 (IL-6) and 8 (IL-8)] were assessed using ELISA; respiratory burst indices [plasma catalase (CAT), superoxide dismutase (SOD), myeloperoxidase (MPO), hydrogen peroxide (H2 O2 ) and nitric oxide (NO)] were evaluated by spectrophotometry. Zinc (Zn) was determined using Atomic Absorption Spectrometry. Phagocytic indices, cytokines and respiratory burst indices were correlated with plasma Zn levels using Spearmans Correlation analysis at P
🔖
Cite This Article
Arinola, G. O., Edem, F. V. (2022). Levels of interleukin-8 and catalase have correlations with zinc in healthy adults: Implications for inflammatory conditions. Annals of Medical Research, Cilt: 28 - Sayı: 11, 1957–1960. https://ajindex.com/articles/446342
Maret W and HH Sandstead. Zinc Requirements and the Risks and Benefits of Zinc Supplementation.J Trace Elem Med Biol 2009
18, 2. Maywald M and L Rink. Zinc Homeostasis and Immunosenescence. J Trace Elem Med Biol 2015
Kambe T, and Tsuji, A. Hashimoto, and N. Itsumura. The Physiological, Biochemical, and Molecular Roles of Zinc Transporters in Zinc Homeostasis and Metabolism. Physiol Rev 2015
Geiser J, KJT Venken, RC de Lisle, and GK. Andrews. A Mouse Model of Acrodermatitis Enteropathica: Loss of Intestine Zinc Transporter ZIP4 (Slc39a4) Disrupts the Stem Cell Niche and Intestine Integrity. PLoS Genet 2012
e1002766. 5. Qin Q, X Wang, and B Zhou. Functional studies of Drosophila zinc transporters reveal the mechanism for dietary zinc absorption and regulation. BMC Biology 2013
Geiser J, RC De Lisle, and GK Andrews. The Zinc Transporter Zip5 (Slc39a5) Regulates Intestinal Zinc Excretion and Protects the Pancreas Against Zinc Toxicity.PLoS One. 2013
e82149. 7. Gao H, L Zhao, H Wang, et al. Metal Transporter Slc39a10 Regulates Susceptibility to Inflammatory Stimuli by Controlling Macrophage Survival. Proc Natl Acad Sci U S A 2017
12940-5. 8. Miyai T, S Hojyo, T Ikawa, et al. Zinc Transporter SLC39A10/ZIP10 Facilitates Antiapoptotic Signaling During Early B-cell Development. Proc Natl Acad Sci U S A 2014
11780-5. 9. Haase H and L. Rink. Signal Transduction in Monocytes: The Role of Zinc Ions.Biometals 2007
Siebenlist U, G Franzoso and K Brown. Structure, Regulation and Function of NF-kappa B.Annu Rev Cell Biol 1994
Brieger A, L. Rink, and H. Haase. Differential Regulation of TLR-dependent MyD88 and TRIF Signaling Pathways by Free Zinc Ions. J of Immunology 2013
Summersgill H, H England, G Lopez-Castejon, et al.Zinc Depletion Regulates the Processing and Secretion of IL-1β. Cell Death & Disease 2014
e1040. 13. Mayer LS, P Uciechowski, S Meyer, et al. Differential Impact of Zinc Deficiency on Phagocytosis, Oxidative Burst, and Production of Pro-Inflammatory Cytokines by Human Monocytes. Metallomics 2014
Wynn TA, A Chawla and JW Pollard. Macrophage Biology in Development, Homeostasis and Disease. Nature 2013
Fraker PJ and LE King. Reprogramming of the immune system during zinc deficiency. Annu Rev Nutr 2004
Hughes DA. Effects of Dietary Antioxidants on the Immune Function of Middle-Aged Adults. Proc Nutr Soc 19