Treated and untreatedsamples were statistically evaluated using an alpha signifiance value of < 0.05.Results: Proliferation and gene expression decreased in the tigecycline administered cultures when compared to the control groupsamples (P < 0.05).Conclusion: Drugs used in clinics may have side effects other than those indicated in their package insert.
📌 3 Key Takeaways
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Objective & Hypothesis:Aim: This study aimed to examine the effects of tigecycline on primary cell cultures established using intervertebral disc tissues.Material and Methods: Primary Annulus Fibrosus and Nucleus Pulposus cultures were obtained from human intervertebral disctissue.
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Key Findings & Data:Untreated samples served as the control group, and treated samples served as the study group.
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Conclusion & Impact:Treated and untreatedsamples were statistically evaluated using an alpha signifiance value of < 0.05.Results: Proliferation and gene expression decreased in the tigecycline administered cultures when compared to the control groupsamples (P < 0.05).Conclusion: Drugs used in clinics may have side effects other than those indicated in their package insert.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters
Abstract
Aim: This study aimed to examine the effects of tigecycline on primary cell cultures established using intervertebral disc tissues.Material and Methods: Primary Annulus Fibrosus and Nucleus Pulposus cultures were obtained from human intervertebral disctissue. Untreated samples served as the control group, and treated samples served as the study group. Treated and untreatedsamples were statistically evaluated using an alpha signifiance value of < 0.05.Results: Proliferation and gene expression decreased in the tigecycline administered cultures when compared to the control groupsamples (P < 0.05).Conclusion: Drugs used in clinics may have side effects other than those indicated in their package insert.
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Cite This Article
YILMAZ, İ., KARAARSLAN, N., KAYA, Y. E., ŞİRİN, D. Y., ÖZBEK, H., BİLİR, B. (2022). In-vitro evaluation of the effects of tigecycline on annulus firosus and nucleus pulposus. Annals of Medical Research, Cilt: 27 - Sayı: 7, 1855–1859. https://ajindex.com/articles/446266
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