Histological examination of renal tissue showed significant prominence ofhistopathological features such as inflammation, necrosis and glomerular congestion in test control group while treated groupsshowed marked reduction.Conclusion: According to the findings of this study, treatment with ascorbic acid or Camellia sinensis extract comparatively exertameliorative effects on lead-induced nephropathy in Wistar rats which in turn culminates into reparative influence on their renalhistomorphology.
📌 3 Key Takeaways
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Objective & Hypothesis:Aim: To compare the ameliorative effects of ascorbic acid and Camellia sinensis extract on renal histomorphology of lead-inducednephropathic rats.Material and methods: Twenty four rats were randomly grouped into four groups (I–IV) as follows: Normal control group Iadministered distilled water (5 ml/kg), Test control group II administered lead acetate (2 mg/ml), Treated group III administered leadacetate (2 mg/ml) + ascorbic acid (100 mg/kg), Treated group IV administered lead acetate (2 mg/ml) + Camellia sinensis extract (10mg/kg).
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Key Findings & Data:All administrations were done through oral route and lasted for 30 days.Results: Body and renal tissue weight of study animals were significantly reduced (p < 0.05) in test control relative to normal controlwhile treated groups showed non-significant reduction.
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Conclusion & Impact:Histological examination of renal tissue showed significant prominence ofhistopathological features such as inflammation, necrosis and glomerular congestion in test control group while treated groupsshowed marked reduction.Conclusion: According to the findings of this study, treatment with ascorbic acid or Camellia sinensis extract comparatively exertameliorative effects on lead-induced nephropathy in Wistar rats which in turn culminates into reparative influence on their renalhistomorphology.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters
Abstract
Aim: To compare the ameliorative effects of ascorbic acid and Camellia sinensis extract on renal histomorphology of lead-inducednephropathic rats.Material and methods: Twenty four rats were randomly grouped into four groups (I–IV) as follows: Normal control group Iadministered distilled water (5 ml/kg), Test control group II administered lead acetate (2 mg/ml), Treated group III administered leadacetate (2 mg/ml) + ascorbic acid (100 mg/kg), Treated group IV administered lead acetate (2 mg/ml) + Camellia sinensis extract (10mg/kg). All administrations were done through oral route and lasted for 30 days.Results: Body and renal tissue weight of study animals were significantly reduced (p < 0.05) in test control relative to normal controlwhile treated groups showed non-significant reduction. Histological examination of renal tissue showed significant prominence ofhistopathological features such as inflammation, necrosis and glomerular congestion in test control group while treated groupsshowed marked reduction.Conclusion: According to the findings of this study, treatment with ascorbic acid or Camellia sinensis extract comparatively exertameliorative effects on lead-induced nephropathy in Wistar rats which in turn culminates into reparative influence on their renalhistomorphology.
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Cite This Article
OMOTOSO, D. R., EHIEMERE, W. P., OWONIKOKO, W. M. (2022). Comparative amelioration of renal histomorphology by ascorbic acid and Camellia sinensis extract in Wistar rats exposed to Lead-induced nephropathy. Annals of Medical Research, Cilt: 27 - Sayı: 8, 2161–2165. https://ajindex.com/articles/446234
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