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Journals / Annals of Medical Research / 2020 / Cilt: 27 - Sayı: 10

A comparative analysis of the effects of esmolol, lidocaine, nitroglycerin and placebo on hemodynamic response to extubation, and extubation quality and postoperative pain

Bengü Gülhan AYDIN
Gamze KÜÇÜKOSMAN
Pages
2617–2624
Publication Date
2022-10-12
DOI
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AI Summary & Key Takeaways

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⚡ TL;DR(Too Long; Didn't Read)

For both indicators, it significantly decreased according to pre- and post excubation records, with the Nitroglycerin group (P

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Objective & Hypothesis:Aim: To comparatively analyze and determine the effects of esmolol, lidocaine, and nitroglycerin on hemodynamic response to extubation, extubation quality and postoperative pain, based on the placebo effect.Material and Methods: Our study design covers a prospective, randomized clinical trial in 120 patients who underwent intubation.
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Key Findings & Data:Random division was applied onto the patients to obtain 4 groups: Esmolol, Lidocaine, Nitroglycerin, and Saline.
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Conclusion & Impact:For both indicators, it significantly decreased according to pre- and post excubation records, with the Nitroglycerin group (P
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Aim: To comparatively analyze and determine the effects of esmolol, lidocaine, and nitroglycerin on hemodynamic response to extubation, extubation quality and postoperative pain, based on the placebo effect.Material and Methods: Our study design covers a prospective, randomized clinical trial in 120 patients who underwent intubation. Random division was applied onto the patients to obtain 4 groups: Esmolol, Lidocaine, Nitroglycerin, and Saline. In preparation for extubation; when the train-of-four (TOF) value reached 75% (basaline), study drugs were administered. When TOF ≥90%, the patients were extubated. Heart rate (HR) and mean blood pressure (MBP) records were taken prior to induction, when TOF 75% and 90, 1st, 3rd, and 5th. minutes after drugs were administered and extubation. Extubation time, quality, and postoperative pain values were recorded.Results: When compared to the Placebo group based on post extubation measurements, the Esmolol group had no significant difference for MBP at any time but lower HR as recorded at the fifth minute (P:0.012). For both indicators, it significantly decreased according to pre- and post excubation records, with the Nitroglycerin group (P

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Cite This Article

AYDIN, B. G., KÜÇÜKOSMAN, G. (2022). A comparative analysis of the effects of esmolol, lidocaine, nitroglycerin and placebo on hemodynamic response to extubation, and extubation quality and postoperative pain. Annals of Medical Research, Cilt: 27 - Sayı: 10, 2617–2624. https://ajindex.com/articles/446085

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References (15)

  1. Lowrie A, Johnston PL, Fell D, et al. Cardiovascular and plasma catecholamine responses at tracheal extubation. Br J Anaesth 1992;68:261-3
  2. Hamaya Y, Dohi S. Differences in Cardiovascular Response to Airway Stimulation at Different Sites and Blockade of The Response by Lidocaine. Anesthesiology 2000;93;95-103
  3. Hartley M, Vaughan RS. Problems associated with tracheal extubation. Br J Anaesth 1993;71:561-8
  4. Cavallone LF, Vannucci A. Review article: Extubation of the difficult airway and extubation failure. Anesth Analg 2013;116:368-83
  5. Asai T, Koga K, Vaughan RS. Respiratory complications associated with tracheal intubation and extubation. Br J Anaesth 1998;80:767-75
  6. Popat M, Mitchell V, Dravid R, et al. Difficult AirwaySociety Guidelines for the management of tracheal extubation. Anaesthesia 2012;67:318-40
  7. Artime CA, Hagberg CA. Tracheal extubation. Respir Care 2014;59:991-1002
  8. Kodali BS, Oberoi J. Management of postoperative pain [Systematic reviews and meta-analyses]. In: Rosenquist EW, Doucette K, editors. UpToDate. Waltham (MA): UpToDate; 2014
  9. Jain S, Khan RM. Effect of perioperative intravenous infusion of lignocaine on haemodynamic responses to intubation, extubation and postoperative analgesia. Indian J Anaesthesia 2015;59:342-7
  10. Shabnum T, Ali Z, Naqash IA, et al. Effects of Lignocaine Administered Intravenously or Intratracheally on Airway and Hemodynamic Responses during Emergence and Extubation in Patients Undergoing Elective Craniotomies in Supine Position. Anesth Essays Res 2017;11:216-22
  11. Harless M, Depp C, Collins S, et al. Role of Esmolol in Perioperative Analgesia and Anesthesia: A Literature Review. AANA J 2015;83:167-77
  12. Nagrale MH, Indurkar PS, Pardhi CS. Comparative study on haemodynamic response to extubation: Attenuation with lignocaine, esmolol, propofol. Int J Res Med Sci 2016;4:144-51
  13. Mikawa K, Hasegawa M, Suzuki T, et al. Attenuation of hypertensive response to tracheal intubation with nitroglycerin. J Clin Anesth 1992;4:367-71
  14. Dyson A, Isaac PA, Pennant JH, et al. Esmolol attenuates cardiovascular responses to extubation. Anesth Analg 1990;71:675-8
  15. Lee JH, Koo BN, Jeong JJ, et al. Differential effects of lidocaine and remifentanil on response to the tracheal tube during emergence from general anaesthesia. Br J Anaesth 2011;106:410-5. 16. van den Berg AA, Savva D, Honjol NM. Attenuation of the haemodynamic responses to noxious stimuli in patients undergoing cataract surgery