SavedAdd your journal

Journals / Annals of Medical Research / 2020 / Cilt: 27 - Sayı: 10

The effect of Fraxin against lung and testis damage induced by testicular torsion/detorsion in rats

Ayhan TANYELİ
Fazile Nur EKİNCİ AKDEMİR
Pages
2769–2774
Publication Date
2022-10-12
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Results: When evaluating current biochemical data, Total oxidant status and malondialdehyde level were significantly elevated, and total antioxidant status and superoxide dismutase activity decreased significantly in the TTD group compared to the sham group (p

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Aim: This study was planned to determine the effect of Fraxin against damage of lung and testis tissues induced by testicular torsion detorsion in the experimental animals.
📊
Key Findings & Data:Groups were designed as sham, testicular torsion/detorsion (TTD), 10 mg/kg Fraxin + TTD (10 mg/kg for 15 days i.p.+2 h torsion;2 h detorsion) and 50 mg/kg Fraxin + TTD (50 mg/kg for 15 days i.p.+2 h torsion;2 h detorsion) groups.
💡
Conclusion & Impact:Results: When evaluating current biochemical data, Total oxidant status and malondialdehyde level were significantly elevated, and total antioxidant status and superoxide dismutase activity decreased significantly in the TTD group compared to the sham group (p
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Aim: This study was planned to determine the effect of Fraxin against damage of lung and testis tissues induced by testicular torsion detorsion in the experimental animals. Material and Methods: For this aim, in this study, experimental animals were weighed and randomize grouped. Groups were designed as sham, testicular torsion/detorsion (TTD), 10 mg/kg Fraxin + TTD (10 mg/kg for 15 days i.p.+2 h torsion;2 h detorsion) and 50 mg/kg Fraxin + TTD (50 mg/kg for 15 days i.p.+2 h torsion;2 h detorsion) groups. After the detorsion period was completed, all subjects were sacrificed by high-dose anaesthesia. At the end of the experiment, testis and lung tissues of rats were taken rapidly for biochemical analyzes. Results: When evaluating current biochemical data, Total oxidant status and malondialdehyde level were significantly elevated, and total antioxidant status and superoxide dismutase activity decreased significantly in the TTD group compared to the sham group (p

🔖

Cite This Article

TANYELİ, A., AKDEMİR, F. N. E. (2022). The effect of Fraxin against lung and testis damage induced by testicular torsion/detorsion in rats. Annals of Medical Research, Cilt: 27 - Sayı: 10, 2769–2774. https://ajindex.com/articles/446032

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (16)

  1. Pogorelic Z, Mrklic I, Juric I, et al.Testicular torsion in the inguinal canal in children. J Pediatr Urol 2013;9:793-7
  2. Yagmurdur H, Ayyildiz A, Karaguzel E, et al. The preventive effects of thiopental and propofol on testicular ischemia-reperfusion injury. Acta Anaesth Scand 2006;50:1238-343
  3. Becker EJ, Turner TT. Endocrine and Exocrine Effects of Testicular Torsion in the Prepubertal and Adult-Rat. J Androl 1995;16:342-51
  4. Dejban P, Rahimi N, Takzare N, et al. Beneficial effects of dapsone on ischemia/reperfusion injury following torsion/detorsion in ipsilateral and contralateral testes in rat. Theriogenol 2019;140:136-42
  5. Unsal A, Devrim E, Guven C, et al. Propofol attenuates reperfusion injury after testicular torsion and detorsion. World J Urol 2004;22:461-5
  6. Turner TT, Brown KJ. Spermatic Cord Torsion - Loss of Spermatogenesis Despite Return of Blood-Flow. Biol Reprod 1993;49:401-7
  7. Aksoy H, Yapanoglu T, Aksoy Y, et al. Dehydroepiandrosterone treatment attenuates reperfusion injury after testicular torsion and detorsion in rats. J Pediatr Surg 2007;42:1740-4
  8. Karaguzel E, Kadihasanoglu M, Kutlu O. Mechanisms of testicular torsion and potential protective agents. Nat Rev Urol 2014;11:391-9
  9. Lysiak JJ, Nguyen QAT, Kirby JL, et al. Ischemiareperfusion of the murine testis stimulates the expression of proinflammatory cytokines and activation of c-jun N-terminal kinase in a pathway to E-selectin expression. Biol Reprod 2003;69:202-10
  10. Salmasi AH, Beheshtian A, Payabvash S, et al. Effect of morphine on ischemia-reperfusion injury: Experimental study in testicular torsion rat model. Urol 2005;66:1338-42
  11. Hamed GM, Ahmed RM, Emara MM, et al. Effect of Erythropoietin on Experimental Unilateral Testicular Torsion Detorsion in Rat Model. Life Sci J 2011;8:405- 12
  12. Tanyeli A, Eraslan E, Polat E, et al. Cryptotanshinone mitigates ischemia reperfusion-induced testicular damage: A experimental study. Ann Med Res 2019;26:2549-52
  13. Topdağı O, Tanyeli A, Ekinci Akdemir FN, et al. The Effects of Higenamine on Testicular Damage Injured by Ischemia Reperfusion A Biochemical Study. Turkish J Sci (TJOS) 2019;4:92-9
  14. Wang HD, Xiao BX, Hao ZQ, et al. Simultaneous determination of fraxin and its metabolite, fraxetin, in rat plasma by liquid chromatography-tandem mass spectrometry and its application in a pharmacokinetic study. J Chromatogr B 2016;1017:70-4
  15. Kostova I. Fraxinus ornus L. Fitoterapia. 2001;72:471- 80
  16. Li WF,