SavedAdd your journal

Journals / Annals of Medical Research / 2021 / Cilt: 28 - Sayı: 5

Inverstigation of corneal and lens densitometry in eyes ofpatients with primary myelofibrosis

Ugur Yilmaz
Gulsum Akgun Cagliyan
Burak Akbay
Pages
1015–1018
Publication Date
2022-10-12
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Lens density was found as statistically significantly higher in the patient group compared to the control group(p

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Aim: To investigate the corneal-lens densitometry and endothelial cells of Primary myelofibrosis patients.
📊
Key Findings & Data:Materials and Methods: We evaluated 49 eyes of 49 primary myelofibrosis patients on follow up in hematology clinic and comparedto 46 eyes of 46 age and sex-matched control group .
💡
Conclusion & Impact:Lens density was found as statistically significantly higher in the patient group compared to the control group(p
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Aim: To investigate the corneal-lens densitometry and endothelial cells of Primary myelofibrosis patients. Materials and Methods: We evaluated 49 eyes of 49 primary myelofibrosis patients on follow up in hematology clinic and comparedto 46 eyes of 46 age and sex-matched control group . The Scheimpflug images of 90–270 degrees by Pentacam HR (OculusOptikgeräte GmbH, Wetzlar, Germany) were used for measurement. After pupil dilatation, the corneal apex was marked by pentacam automatically and the diameter of central 6 mm around marked point was analyzed. PNS (Pentacam Nuclear Staging) software was used for densitometric analysis of the lens from a cylindrical region in the nucleus center. Specular Microscope CEM-530 (Nidek, Japan) was used for endothelial cell analysis. Results: There was no statistically significant difference between groups for age and gender(Table1). Corneal density and cornealvolume were higher in the patient group but it was not statistically significant (respectively p=0.390, p=0.078). Lens density was found as statistically significantly higher in the patient group compared to the control group(p

🔖

Cite This Article

Yilmaz, U., Cagliyan, G. A., Akbay, B. (2022). Inverstigation of corneal and lens densitometry in eyes ofpatients with primary myelofibrosis. Annals of Medical Research, Cilt: 28 - Sayı: 5, 1015–1018. https://ajindex.com/articles/445904

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (15)

  1. K Kaushansky, MA Lichtman, E Beutler, et al. Primary Myelofibrosis. Williams Hematology 8th Edition. 2010;1381-99
  2. Fontenay-Roupie M, Dupuy E, Berrou E, et al. Increased proliferation of bone marrow-derived fibroblasts in primitive hypertrophic osteoarthropathy with severe myelofibrosis. Blood 1995;85:3229-38
  3. Tanaka H, Maehama S, Imanaka F, et al. Pachydermoperiostosis with myelofibrosis and anemia: report of a case of anemia of multifactorial causes and its improvement with steroid pulse and iron therapy. Jpn J Med 1991;30:73-80
  4. Bonner JC. Regulation of PDGF and its receptors in fibrotic diseases. Cytokine Growth F R 2004;15:255- 73
  5. Barosi G. Essential thrombocythemia vs early/ prefibrotic myelofibrosis: why does it matter. Best Pract Res Clin Haematol 2014;27:129-140
  6. Kim MJ, Yu HG. Case of bilateral retinal neovascularization associated with chronic idiopathic myelofibrosis. Korean J Ophthalmol 2010;24:131-3
  7. Neufeld KR, Price K, Woodward JA. Massive eyelid thickening in pachydermoperiostosis with myelofibrosis. Ophthalmic Plast Reconstr Surg 2009;25:316-8
  8. Haskes C, Gagnon K. Retinal manifestations of idiopathic myelofibrosis, a hematologic disorder. J Am Optom Assoc 1998;69:319-28
  9. Lin AL, Burnham JM, Pang V, et al. Ocular manifestations of primary myelofıbrosıs. Retin Cases Brief Rep 2016;10:364-7
  10. Nishi O, Nishi K, Ohmoto Y. Synthesis of interleukin-1, interleukin-6, and basic fibroblast growth factor by human cataract lens epithelial cells J Cataract Refr Surg 1996;22: 852-8 11. Klein EKB, Klein R, Lee KE, et al. Markers of inflammation, vascular endothelial dysfunction, and age-related cataract Am J Ophthalmol 2006;141:116- 22
  11. Dudek EJ, Shang F, Taylor A. H(2)O(2)-mediated oxidative stress activates NF-kappa B in lens epithelial cells Free Radic Biol Med 2001;31:651-8
  12. Wormstone IM, Wang L, Liu CS. Posterior capsule opacification. Exp Eye Res 2009;88:257-69
  13. Ray S, Gao C, Wyatt K, et al. Platelet-derived growth factor D, tissue-specific expression in the eye, and a key role in control of lens epithelial cell proliferation. J Biol Chem 2005;280:8494-502
  14. Mads Emil Bjørn and Hans Carl Hasselbalch. The Role of Reactive Oxygen Species in Myelofibrosis and Related Neoplasms. Mediators Inflamm 2015;648090
  15. Brennan LA1, Kantorow M. Mitochondrial function and redox control in the aging eye: role of MsrA and other repair systems in cataract and macular degenerations. Exp Eye Res 2009;88:195-203