Journals / Ankara Üniversitesi Diş Hekimliği Fakültesi Dergisi / 2002 / Cilt: 29 - Sayı: 3

An ultrastructural study of the fibroblasts in healthy and diseased gingiva

Sağlıklı ve hastalıklı diş etlerinde fibroblastlar üzerine incelemeler

Pages
289–297
Publication Date
2022-10-10
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Furthermore, some degenerative formations have appeared in inflammed connective tissue.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:In this study, fibroblast within the gingival tissue in periodontitis patients were examined.
📊
Key Findings & Data:In early gingiva inflammatory lesions, the connective tissue space adjacent to the pocket epithelium was infiltrated with lymphocytes, monocytes, neutrophils and eusinophils.
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Conclusion & Impact:Furthermore, some degenerative formations have appeared in inflammed connective tissue.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

In this study, fibroblast within the gingival tissue in periodontitis patients were examined. Biopsy materials were obtained from three adult patients during the flap operations. The sections prepared from tissue biopsies were studied by light and electron microscopy in clinically healthy and diseased gingiva. It was observed that oral epithelium maintains its normal structure and fibroblasts had normal ultrastructural features in gingiva which have healthy clinic criteria. In early gingiva inflammatory lesions, the connective tissue space adjacent to the pocket epithelium was infiltrated with lymphocytes, monocytes, neutrophils and eusinophils. In addition fibroblasts in early inflammed gingival connective tissue, showed some structural alterations. Rough endoplasmic reticulum in mitochondrial cisternaes were found to be dilated. For the chronic inflammatory lesions connective tissue showed degenerative changes. Completely degenerated organells were observed of some fibroblast. Some of them were also enlarged and rounded. Dilation of rough endoplasmic reticulum, lack of cisternae in the mitochondria, cisternael dilation, disperted chromatin were observed in the chronically inflammed connective tissue. Furthermore, some degenerative formations have appeared in inflammed connective tissue.

Özet

Bu çalışmada; periodontitis'li hastalarda dişeti dokusundaki fibroblastlar incelendi. Biyopsi materyalleri, yetişkin periodontitis'li üç hastadan flap operasyonu sırasında elde edildi. Doku biyopsilerinden hazırlanan kesitler, ışık ve elektron mikroskobunda incelendi. Sağlıklı klinik kriterlere sahip dişetinde, oral epitel ve fibroblastların normal yapısını koruduğu gözlendi. Dişetinin erken lezyonlarında (gingivitis), cep epiteline bitişik olan bağ dokusu alanlarına çeşitli lenfositler, monositler, nötrofil ve eozinofiller infiltre olmuştur. Ayrıca erken lezyonlarda bulunan bağ dokusundaki fibroblastların bazı değişikliklere sahip olduğu görüldü. Granüllü endoplazmik retikulum sisternalarında genişlemelerin olduğu belirlendi. Bağ dokusunun ilerlemiş lezyon (periodontitis)'rında, dejeneratif değişikliklerin olduğu gözlendi. Organellerinin tamamı dejenere olmuş bazı fibroblastlar da belirlendi. İlerlemiş lezyona sahip bağ dokusu içindeki bazı fibroblastlarda da E.R'lerde genişleme ve kesecik oluşturma, mitokondri sisternalarında genişleme, kromatinin dağınık olarak yer alması gibi bazı gözlemler de yapıldı. Ayrıca bazı dejeneratif artık yapıların bağ dokusu iltihab hücreleri ile kaplı olan alanlarında yer aldığı da gözlenmiştir.

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Cite This Article

BOSTANCI, H., AYVALI, C., TAŞTAN, H. (2022). An ultrastructural study of the fibroblasts in healthy and diseased gingiva. Ankara Üniversitesi Diş Hekimliği Fakültesi Dergisi, Cilt: 29 - Sayı: 3, 289–297. https://ajindex.com/articles/442299

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