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Journals / Ankara Medical Journal / 2018 / Cilt: 18 - Sayı: 3

The Association of IGF‐1 with Clinical Symptoms in Female Patients with Fibromyalgia Syndrome

Fibromiyalji Sendromlu Kadın Hastalarda IGF‐1'in Klinik Semptomlarla İlişkisi

Sevgi GÜMÜŞ ATALAY
Pages
410–418
Publication Date
2022-10-12
DOI
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AI Summary & Key Takeaways

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⚡ TL;DR(Too Long; Didn't Read)

The IGF‐1 levels were significantly correlated with age (r=‐0.496; p

📌 3 Key Takeaways

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Objective & Hypothesis:Introduction: Fibromyalgia syndrome (FMS) is a disease of unknown etiology, which is characterisedby chronic pain.
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Key Findings & Data:Disturbed growth hormone response, low serum insulin‐like growth factor‐1 (IGF‐1)may play a role in etiopathogenesis of fibromyalgia and may be related to the severity of some symptom.The aim of this study is to investigate serum IGF‐1 levels and relationship of clinical symptoms in femalepatients with fibromyalgia syndrome.Materials and Methods: Thirty‐seven patients with FMS and thirty healthy subjects were included inthis study.
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Conclusion & Impact:The IGF‐1 levels were significantly correlated with age (r=‐0.496; p
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Introduction: Fibromyalgia syndrome (FMS) is a disease of unknown etiology, which is characterisedby chronic pain. Disturbed growth hormone response, low serum insulin‐like growth factor‐1 (IGF‐1)may play a role in etiopathogenesis of fibromyalgia and may be related to the severity of some symptom.The aim of this study is to investigate serum IGF‐1 levels and relationship of clinical symptoms in femalepatients with fibromyalgia syndrome.Materials and Methods: Thirty‐seven patients with FMS and thirty healthy subjects were included inthis study. All individuals were assessed for clinical findings, widespread pain (Visual Analogue Scale),functional disability and health state (health assesment questionnarie and fibromyalgia impactquestionnarie), anxiety (anxiety State and Trait Anxiety Inventory) and depression (Beck depressioninventory). Likert scale was used for evaluate morning stiffness, level of fatigue, pain, muscle spasm andtenderness.Results: In this study, serum IGF‐1 levels of patients with fibromyalgia were significantly lowercompared to the control group (p=0.004). The IGF‐1 levels were significantly correlated with age (r=‐0.496; p

Özet

Amaç: Fibromiyalji sendromu (FMS), kronik ağrı ile karakterize, etiyolojisi bilinmeyen bir hastalıktır. Bozulmuş büyüme hormonu yanıtı, düşük serum insülin benzeri büyüme faktörü‐1 (IGF‐1) FMS etyopatogenezinde rol oynayabilir ve bazı semptomların şiddeti ile bağlantılı olabilir. Bu çalışmanın amacı fibromiyalji sendromlu kadın hastalarda serum IGF‐1 düzeylerini ve klinik semptomlarla ilişkisini araştırmaktır. Materyal ve Metot: Çalışmaya FMS’lu 37 kadın hasta ve 30 sağlıklı kadın dahil edildi. Tüm bireyler klinik bulgular, ağrı şiddeti (görsel ağrı skalası), fonksiyonel disabilite ve sağlık durumu (sağlık değerlendirme skalası ve fibromiyalji etki skalası), anksiyete (anlık ve sürekli anksiyete ölçeği) ve depresyon (Beck depresyon ölçeği) açısından değerlendirildi. Sabah sertliği, yorgunluk şiddeti, uykusuzluk şiddeti, ağrı şiddeti, kas spazmı şiddeti ve hassasiyet şiddetini değerlendirmek için Likert skalası kulanıldı. Bulgular: Çalışmamızda FMS hastalar kontrol grubuyla kıyaslandığında serum IGF‐1 düzeyleri belirgin olarak daha düşüktü (p=0,004). IGF‐1 düzeyi ile yaş (r=‐0,496; p

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Cite This Article

ATALAY, S. G. (2022). The Association of IGF‐1 with Clinical Symptoms in Female Patients with Fibromyalgia Syndrome. Ankara Medical Journal, Cilt: 18 - Sayı: 3, 410–418. https://ajindex.com/articles/441951

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