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Journals / Ankara Medical Journal / 2020 / Cilt: 20 - Sayı: 3

EVALUATION OF SCUBE-1 LEVEL AND CAROTID INTIMA MEDIA THICKNESS IN RECURRENT PREGNANCY LOSS

TEKRARLAYAN GEBELİK KAYIPLARINDA SCUBE-1 DÜZEYİNİN VE KAROTİS İNTİMA MEDİA KALINLIĞININ DEĞERLENDİRİLMESİ

Sabri COLAK
Emine Seda GUVENDAG GUVEN
Suleyman GUVEN
Turan ERDOGAN
Yesim BAYOGLU TEKİN
Funda AKPİNAR
Pages
730–742
Publication Date
2022-10-12
DOI
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AI Summary & Key Takeaways

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⚡ TL;DR(Too Long; Didn't Read)

Future studies may shed light on the diagnosis, treatment, and management of RPL.

📌 3 Key Takeaways

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Objective & Hypothesis:Objectives: Evaluation of the signal peptide complement C1r/C1s, Uegf, and Bmp1 (CUB), and epidermal growth factor-like domain-containing protein-1 (SCUBE-1) levels and carotid intima media thickness (CIMT) between the group of patients with and without recurrent pregnancy loss (RPL).Materials and Methods: This prospective and single-center study included 20-40-year-old 30 patients with and 30 patients without a history of RPL.
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Key Findings & Data:A comparison of SCUBE-1 levels and CIMT were made between the patient and control groups.Results: There were no statistically significant differences between patients and control groups in terms of demographic characteristics except for gravidity, parity, and miscarriages.
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Conclusion & Impact:Future studies may shed light on the diagnosis, treatment, and management of RPL.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Objectives: Evaluation of the signal peptide complement C1r/C1s, Uegf, and Bmp1 (CUB), and epidermal growth factor-like domain-containing protein-1 (SCUBE-1) levels and carotid intima media thickness (CIMT) between the group of patients with and without recurrent pregnancy loss (RPL).Materials and Methods: This prospective and single-center study included 20-40-year-old 30 patients with and 30 patients without a history of RPL. No patients with any anatomical, hereditary, or endocrinological thrombophilic defects were included. A comparison of SCUBE-1 levels and CIMT were made between the patient and control groups.Results: There were no statistically significant differences between patients and control groups in terms of demographic characteristics except for gravidity, parity, and miscarriages. The mean SCUBE-1 level in the RPL group was statistically significantly higher compared to the control group (16.44±5.43 vs.10.17±5.19, respectively, p=0.001). The mean CIMT value in RPL patients was statistically significantly higher than that of the control group (0.60±0.09 vs.0.44±0.07, respectively, p=0.001).Conclusion: High levels of serum SCUBE-1 and CIMT in RPL may suggest that ischemia and endothelial dysfunction may be involved in the etiology of RPL. Future studies may shed light on the diagnosis, treatment, and management of RPL.

Özet

Amaç: Tekrarlayan gebelik kaybı olan hasta grubu ile tekrarlayan gebelik kaybı öyküsü olmayan hasta grubu arasında serum signal peptid C1r/C1s, Uegf, ve Bmp1 (CUB) epidermal growth factor-like domain-containing protein-1 (SCUBE-1) düzeyinin ve karotis intima media kalınlığının değerlendirilmesi. Materyal ve Metot: Prospektif ve tek merkezli çalışmaya 20-40 yaş arasında 30 tekrarlayan gebelik kaybı öyküsü olan, 30 tekrarlayan gebelik kaybı öyküsü olmayan hasta olgusu alınmıştır. Tekrarlayan gebelik kaybı olanlarda ve kontrol grubunda anatomik, kalıtımsal, endokrin, trombofilik defekti olanlar çalışma kapsamına alınmamıştır. Hasta grubu ile kontrol grubu arasında SCUBE-1 düzeyinde ve ölçülen karotis intima media kalınlığı arasında istatistiksel fark olup olmadığı araştırılmıştır. Bulgular: Demografik özellikler açısından hastalar ve kontrol grupları arasında gravite, parite ve düşükler dışında istatistiksel olarak anlamlı fark bulunmamıştır. TGK kaybı olan hastaların ortalama SCUBE1 düzeyleri (16,44±5,43) kontrol grubunun ortalama SCUBE1 düzeylerinden (10,17±5,19) istatistiksel olarak anlamlı şekilde yüksektir (p=0,001). TGK kaybı olan hastaların ortalama CIMT düzeyleri (0,60±0,09) kontrol grubunun ortalama CIMT düzeylerinden (0,44±0,07) istatistiksel olarak anlamlı şekilde yüksektir (p=0,001). Sonuç: TGK olan grupta yüksek serum SCUBE-1 ve CIMT seviyeleri, iskemi ve endotel disfonksiyonunun TGK etiyolojisinde rol oynayabileceğini düşündürebilir. Gelecekteki çalışmalar TGK'nın tanı, tedavi ve yönetimine ışık tutabilir.

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Cite This Article

COLAK, S., GUVEN, E. S. G., GUVEN, S., ERDOGAN, T., TEKİN, Y. B., AKPİNAR, F. (2022). EVALUATION OF SCUBE-1 LEVEL AND CAROTID INTIMA MEDIA THICKNESS IN RECURRENT PREGNANCY LOSS. Ankara Medical Journal, Cilt: 20 - Sayı: 3, 730–742. https://ajindex.com/articles/441830

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References (13)

  1. Bender Atik R, Christiansen OB, Elson J, et al. ESHRE guideline: recurrent pregnancy loss. Hum Reprod Open. 2018;2018(2):hoy004 (doi:10.1093/hropen/hoy004)
  2. Stephenson MD. Frequency of factors associated with habitual abortion in 197 couples. Fertil Steril. 1996;66(1):24-9
  3. Preston FE, Rosendaal FR, Walker ID, et al. Increased fetal loss in women with heritable thrombophilia. Lancet. 1996;348(9032):913-6 (doi:10.1016/s0140-6736(96)04125-6)
  4. Greenwold N, Jauniaux E, Gulbis B, Hempstock J, Gervy C, Burton GJ. Relationship among maternal serum endocrinology, placental karyotype, and intervillous circulation in early pregnancy failure. Fertil Steril. 2003;79(6):1373-9 (doi:10.1016/s0015-0282(03)00364-9)
  5. Tu CF, Yan YT, Wu SY, et al. Domain and functional analysis of a novel platelet-endothelial cell surface protein, SCUBE1. J Biol Chem. 2008;283(18):12478-88 (doi:10.1074/jbc.M705872200)
  6. Xavier GM, Economou A, Senna Guimaraes AL, Sharpe PT, Cobourne MT. Characterization of a mouse Scube3 reporter line. Genesis. 2010;48(12):684-92 (doi:10.1002/dvg.20678)
  7. Bayoglu Tekin Y, Baki Erin K, Yilmaz A. Evaluation of SCUBE-1 levels as a placental dysfunction marker at gestational diabetes mellitus. Gynecol Endocrinol. 2020;36(5):417-20 (doi:10.1080/09513590.2019.1683537)
  8. Dai DF, Thajeb P, Tu CF, et al. Plasma concentration of SCUBE1, a novel platelet protein, is elevated in patients with acute coronary syndrome and ischemic stroke. J Am Coll Cardiol. 2008;51(22):2173-80 (doi:10.1016/j.jacc.2008.01.060)
  9. Mensah GA. Healthy endothelium: the scientific basis for cardiovascular health promotion and chronic disease prevention. Vascul Pharmacol. 2007;46(5):310-4 (doi:10.1016/j.vph.2006.10.013)
  10. Altin C, Yilmaz M, Ozsoy HM, et al. Assessment of epicardial fat and carotid intima media thickness in gestational hypertension. J Obstet Gynaecol Res. 2018;44(6):1072-9 (doi:10.1111/jog.13631)
  11. Carpenter M, Sinclair H, Kunadian V. Carotid Intima Media Thickness and Its Utility as a Predictor of Cardiovascular Disease: A Review of Evidence. Cardiol Rev. 2016;24(2):70-5 (doi:10.1097/CRD.0000000000000077)
  12. Lamarca B. The role of immune activation in contributing to vascular dysfunction and the pathophysiology of hypertension during preeclampsia. Minerva Ginecol. 2010;62(2):105-20
  13. Burton GJ, Jauniaux E. Pathophysiology of placental-derived fetal growth restriction. Am J Obstet Gynecol. 2018;218(2S):S745-S61 (doi:10.1016/j.ajog.2017.11.577). 14.