Journals / Ankara Eğitim ve Araştırma Hastanesi Tıp Dergisi / 2019 / Cilt: 52 - Sayı: 2

RADIOTHERAPY FOR PITUITARY ADENOMAS

HİPOFİZ ADENOMLARINDA RADYOTERAPİ

Pages
174–180
Publication Date
2022-10-11
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

As a result, in hypophysis tumors refractory to other treatment modalities, radiotherapy must be kept in mind as a minimally invasive, safe and effective option.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Despite improvements in surgical technics and medical treatment a significant number of pituitary adenomas may remain endocrinologically active, may exhibit radiologically persistent disease or may recur.
📊
Key Findings & Data:Although with this type of treatment endocrinological remission rates are highly variable, they are good and radiological tumor control rates are high.
💡
Conclusion & Impact:As a result, in hypophysis tumors refractory to other treatment modalities, radiotherapy must be kept in mind as a minimally invasive, safe and effective option.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Despite improvements in surgical technics and medical treatment a significant number of pituitary adenomas may remain endocrinologically active, may exhibit radiologically persistent disease or may recur. Day after day, radiotherapy in these persistent adenoma types, becomes an important treatment modality. Although with this type of treatment endocrinological remission rates are highly variable, they are good and radiological tumor control rates are high. After radiotherapy, depending on tumor type and size, radiothepay type, hipopituitarism at the highest rate, and less likely neurological and vascular complications are found. As a result, in hypophysis tumors refractory to other treatment modalities, radiotherapy must be kept in mind as a minimally invasive, safe and effective option.

Özet

Cerrahi teknik ve medikal tedavilerdeki gelişmelere rağmen önemlibir sayıda hipofiz adenomu endokrinojik olarak aktif kalabilir,radyolojik olarak persistan hastalık sergileyebilir veya nüksedebilir.Radyoterapi bu ısrarcı adenom tiplerinde gün geçtikçe daha önemlibir tedavi modalitesi olmaktadır. Bu tedavi şekli ile endokrinolojikremisyon oranları değişken olmakla birlikte iyidir ve radyolojiktümör kontrol oranları yüksektir. Radyoterapi sonrası tümörtipi ve boyutu, verilen radyoterapi şekli ile uyumlu olmak üzerehipopitüitarizm en yüksek oranda, daha az oranlarda nörolojik vevasküler komplikasyonlara rastlanmaktadır. Sonuç olarak diğertedavi şekillerine refrakter hipofiz tümörlerinde minimal envaziv,emin ve efektif bir opsiyon olarak radyoterapi akla getirilmelidir.

🔖

Cite This Article

GÜRSOY, G., ÇARMIKLI, B. D. (2022). RADIOTHERAPY FOR PITUITARY ADENOMAS. Ankara Eğitim ve Araştırma Hastanesi Tıp Dergisi, Cilt: 52 - Sayı: 2, 174–180. https://ajindex.com/articles/441290

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (12)

  1. )Deyneli O, Yazıcı D. Radiotherapy for pituitary adenomas. Turkiye Klinikleri J Int Med Sci. 2006
  2. )Landolt AM, Haller D, Domax N et al, Stereotactic radiosurgery for recurrent surgically treated acromegaly: comparison with fractioned radiotherapy. J Neurosurg. 1998
  3. )Sheehan JP, Pouratian N, Steiner L, Laws ER, Vance MI, Gama Knife surgery for pituitary adenomas: factors related to radiological and endocrine outcomes. J Neurosurg. 2011
  4. )Castinetti F, Nagai M, Dufour H, Kuhn JM, Morangel I, Jaquet P et al, Gama Knife surgery is a successful adjunctive treatment in Cushing’s disease. Eur J Endocrinol. 2007
  5. )Brochier S, Galland F, Kujas M, Parker F, Gaillard S, Raftopoulos C et al, Factors predicting relapse of nonfunctioning pituitary macroadenomas after neurosurgery. A study of 142 patients. Eur J Endocrinol. 2010
  6. )Chang EF, Zada G, Kim S, Lamborn KR, Quinones-Hinojosa A, Tyrrell JB et al, Long term recurrence and mortality after surgery and adjuvant radiotherapy for nonfunctional pituitary adenomas. J Neurosurg. 2008,108:736-45. 7.)Erridge SC, Conkey DS, Stockton D, Strachan MW, Statham PF, Whittle IR et al, Radiotherapy for pituitary adenomas: long-term efficacy and toxicity. Radiother Oncol. 2009
  7. )Loeffler JS, Shih HA, Radiation therapy in the management of pituitary adenomas. J Clin Endocrinol Metab. 2011
  8. )Zierhut D, Flentje M, Adolph J, Erdmann J, Raue F, Wannenmacher M, External radiotherapy of pituitary adenomas. Int J Radiat Oncol Biol Phys. 1995,33: 307-14. 10.)Colin P, Jovenin N, Delemer B, Caron J, Grule H, Hecart AC et al, Treatment of pituitary adenomas by fractioned stereotactic radiotherapy: a prospective study of 110 patients. Int J Radiat Oncol biol Phys. 2005
  9. )Paek SH, Downes MB, Bednarz G, Keane WM, Werner-Wasik M, Curran WJ Jr et al, Integration of surgery with fractioned stereotactic radiotherapy of nonfunctional pituitary adenomas. Int J Radiat Oncol Biol Phys. 2005
  10. )Ronson BB, Schulte RW, Han KP, Loredo LN, Slater JM, Slater JD, Fractioned proton beam irradiation of pituitary adenomas. Int J Radiat Oncol Biol Phys. 2006
  11. )Sheehan JP, Nirajan A, Sheehan JM, Jane JA Jr, Laws ER, Kondziolka D et al, Stereotactic radisurgery for pituitary adenomas. An internmediate review of its safety,efficacy and role in the neurosurgical treatment armamentarium. J Neurosurg. 2005
  12. )Mingione V,