Journals / An International Journal of Optimization and Control: Theories & Applications (IJOCTA) / 2019 / Cilt: 9 - Sayı: 3

Simulation of glucose regulating mechanism with an agent-based software engineering tool

Pages
15–20
Publication Date
2022-10-11
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Finally, this study which is thought a potential implementation ofagent-based modeling and simulation may contribute to the exploration of otherhomeostatic control systems inside the human body

📌 3 Key Takeaways

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Objective & Hypothesis:This study provides a detailed explanation of a regulating mechanism of theblood glucose levels by an agent-based software engineering tool.
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Key Findings & Data:The result of this study shows the local behavior of theagents in the negative feedback loop and illustrates how to balance the bloodglucose levels.
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Conclusion & Impact:Finally, this study which is thought a potential implementation ofagent-based modeling and simulation may contribute to the exploration of otherhomeostatic control systems inside the human body
🔬Design:Modeling & Simulation
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

This study provides a detailed explanation of a regulating mechanism of theblood glucose levels by an agent-based software engineering tool. RepastSimphony which is used in implementation of this study is an agent-basedsoftware engineering tool based on the object-oriented programming using Javalanguage. Agent-based modeling and simulation is a computational methodologyfor simulating and exploring phenomena that includes a large set of activecomponents represented by agents. The agents are main components situated inspace and time of agent-based simulation environment. In this study, we presenthormonal regulation of blood glucose levels by our improved agent-basedcontrol mechanism. Hormonal regulation of blood glucose levels is an importantprocess to maintain homeostasis inside the human body. We offer a negativefeedback control mechanism with agent-based modeling approach to regulate thesecretion of insulin hormone which is responsible for increasing the bloodglucose levels. The negative feedback control mechanism run by three mainagents that interact with each other to perform their local actions in thesimulation environment. The result of this study shows the local behavior of theagents in the negative feedback loop and illustrates how to balance the bloodglucose levels. Finally, this study which is thought a potential implementation ofagent-based modeling and simulation may contribute to the exploration of otherhomeostatic control systems inside the human body

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Cite This Article

EMEK, S., EVREN, V., BORA, Ş. (2022). Simulation of glucose regulating mechanism with an agent-based software engineering tool. An International Journal of Optimization and Control: Theories & Applications (IJOCTA), Cilt: 9 - Sayı: 3, 15–20. https://ajindex.com/articles/440586

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References (1)

  1. Jhonstone, K., & Adam, K. (2012). The Human: As a Biological System. Core Body of Knowledge for the Generalist OHS Professional. Safety Institute of Australia Ltd, Tullamarine, Victoria, Australia [2] Marieb, E.N., & Hoehn, K. (2010). Human Anatomy and Physiology. 8th ed., San Francisco: Benjamin Cummings, 634-654. [3] Guyton, A.C., & Hall J.E. (2006). Textbook of Medical Physiology. Elseiver Inc, 11th ed. [4] Klügl, F. & Bazzan, A.L.C. (2012). Agent-Based Modeling and Simulation. Association for the Advancement of Artificial Intelligence, 29-40. [5] Bandini, S., Manzoni, S.T., & Vizzari, G. (2009). Agent Based Modeling and Simulation: An Informatics Perspective. Journal of Artificial Societies and Social Simulation, vol. 12. [6] Bonabeau, E. (2002). Agent-based modeling: Methods and techniques for simulating human systems. Proceedings of the National Academy of Sciences of the United States of America (PNAS), 99(3), 7280-7287. [7] Bora, Ş., Evren, V., Emek, S., & Çakırlar, I. (2017). Agent-based modeling and simulation of blood vessels in the cardiovascular system. Simulation: Transactions of the Society for Modeling and Simulation International, 1-16. Doi: 10.1177/0037549717712602 [8] DeAngelis, D.L., & Grimm V. (2014). Individualbased models in ecology after four decades. F1000Prime Reports; 6:39. DOI: 10. 12703/P6-39 [9] Macal, C.M., & North, M.J. (2010). Tutorial on agent-based modelling and simulation. Journal of Simulation, 4:151-162. DOI: 10.1057/jos.2010.3 [10] Ramaprased, R. (1983). On the Definition of Feedback. Behavioral Science, 28(1):4-13. [11] Nikolai, C., & Madey, G. (2009). Tools of the trade: a survey of various agent based modeling platforms. J. Artif. Soc. Social Simul., vol. 12. [12] James, P., & McFadden R. (2004). Understanding the processes behind the regulation of blood glucose. Diabetes Knowledge, 100(16):56-58. [13] Bora, Ş., Emek, S., Evren, V. (2017). An Agentbased Approach in Homeostatic Control Systems: Thermoregulation. IEEE 9th International Conference on Computational Intelligence and Communication Networks, 113-116. DOI: 10.1109/CICN.2017.8319367 [14] Wang, X., Misava, R., Zielinski, M.C., Cowen, P., Jo, J., Periwal, V., Ricordi, C., Khan, A., Szust, J., Shen, J., Millis, J.M., Witkowski, P., & Hara, M. (2013). Regional Differences in Islet Distribution in the Human Pancreas - Preferential Beta-Cell Loss in the Head Region in Patients with Type 2 Diabetes. PloS One, vol. 8(6). [15] Krull, D.L., & Peterson, R.A. (2011