Journals / Anadolu Üniversitesi Bilim ve Teknoloji Dergisi :C-Yaşam Bilimleri ve Biyoteknoloji / 2018 / Cilt: 7 - Sayı: 2

HISTOLOGICAL EXAMINATION OF THE ROLE OF VITAMIN E IN CYCLOPHOSPHAMIDE-INDUCED TESTICULAR DAMAGE IN RATS

SIÇANLARDA SİKLOFOSFAMİDE BAĞLI TESTİS HASARINDA VİTAMİN E'NİN ROLÜNÜN HİSTOLOJİK OLARAK İNCELENMESİ

Pages
220–226
Publication Date
2022-10-11
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Results of the present study indicate that the testicular injuryinduced by CP can be prevented by administration of vitamin E.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Cyclophosphamide is among anticancerous and immunosuppressing drugs frequently used in chemotherapy treatment.Cyclophosphamide is a chemotherapeutic agent but has also toxic effect on testes.
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Key Findings & Data:Testicular cells can be protected from toxiceffects by antioxidant systems, including vitamin E.
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Conclusion & Impact:Results of the present study indicate that the testicular injuryinduced by CP can be prevented by administration of vitamin E.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Cyclophosphamide is among anticancerous and immunosuppressing drugs frequently used in chemotherapy treatment.Cyclophosphamide is a chemotherapeutic agent but has also toxic effect on testes. Testicular cells can be protected from toxiceffects by antioxidant systems, including vitamin E. The aim of this study is to reveal what kind of effects the vit-E exerts uponexperimentally induced CP toxicity in testicular tissue of rats. Results of the present study indicate that the testicular injuryinduced by CP can be prevented by administration of vitamin E.

Özet

Siklofosfamid, kemoterapi tedavisinde sıklıkla kullanılan antikanser ve immünosüpresan ilaçlar arasındadır. Siklofosfamid kemoterapötik bir ajandır ancak testis üzerinde toksik etkiye sahiptir. Testis hücreleri, E vitamini gibi antioksidan sistemler ile bu toksik etkilerden korunabilir. Bu çalışmanın amacı, vit E'nin sıçanlarda testiküler doku üzerinde deneysel olarak uyarılan CP toksisitesine ne tür bir etki uyguladığını açığa çıkarmaktır. Bu çalışmanın sonuçları, CP ile indüklenen testikular hasarın vitamin E'nin verilmesiyle önlenebildiğini göstermektedir.

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Cite This Article

YETİM, İ., DÖNMEZ, D. B. (2022). HISTOLOGICAL EXAMINATION OF THE ROLE OF VITAMIN E IN CYCLOPHOSPHAMIDE-INDUCED TESTICULAR DAMAGE IN RATS. Anadolu Üniversitesi Bilim ve Teknoloji Dergisi :C-Yaşam Bilimleri ve Biyoteknoloji, Cilt: 7 - Sayı: 2, 220–226. https://ajindex.com/articles/438582

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