AI Summary & Key Takeaways
AI InsightAccording to these results, we concluded that quetiapinetreatment induced hepatotoxic effects in rats, dose-dependently.
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Abstract
Quetiapine is an atypical antipsychotic drug used for treatments of patients with schizophrenia. Although hepatotoxic effectsrelated to quetiapine treatment were reported in a few studies, potential hepatotoxicity of this drug was not identified. Therefore,it was aimed to evaluate the possible hepatotoxic effects of quetiapine by oral administration of this drug at 10 and 20 mg/kgdoses to rats for 30 days in our study. For this purpose, plasma aspartate aminotransferase, alanine aminotransferase, totalbilirubin and direct bilirubin levels as markers of hepatotoxicity were determined and histopathological examination wasperformed in liver tissues. Additionally, we evaluated GSH levels in liver tissues. According to our results, serum aspartateaminotransferase and alanine aminotransferase levels were significantly increased in quetiapine-administered groups, whereastotal and direct bilirubin levels were significantly increased in the high dose group. Histopathological investigation of livertissue indicated that necrotic regions were present in 10 mg/kg quetiapine-administered group whereas prevalent necroticregions accompanying sinusoidal dilatation were observed in 20 mg/kg quetiapine-administered group. Otherwise, there is notany significant difference among groups in terms of GSH levels. According to these results, we concluded that quetiapinetreatment induced hepatotoxic effects in rats, dose-dependently.