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Journals / Anadolu Psikiyatri Dergisi / 2020 / Cilt: 21 - Sayı: 3

Low HO-1 and High KEAP1 Serum Levels in Children with Attention Deficit Hyperactivity Disorder: The First Clinical Study

Dikkat Eksikliği Hiperaktivite Bozukluğu Olan Çocuklarda Düşük HO-1 ve Yüksek KEAP1 Serum Düzeyleri

Hamza AYAYDIN
İsmail KOYUNCU
Hakim ÇELİK
Adnan KİRMİT
İsmail AKALTUN
Hatice TAKATAK
Pages
319–326
Publication Date
2022-10-10
DOI
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Results: HO-1 levels in the patient group were significantly lower than in the control group, while KEAP1 levels were significantly higher, but no significant difference was observed between the groups in terms of NRF2 (p=0.041, p

📌 3 Key Takeaways

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Objective & Hypothesis:Objective: The purpose of this study was therefore to evaluate serum heme oxygenase-1 (HO-1), kelch-like ECHassociated protein 1 (KEAP1), and nuclear factor erythroid 2 related factor 2 (NRF2) levels in children with attention deficit hyperactivity disorder (ADHD) and to reveal their association with the severity of ADHD.
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Key Findings & Data:Methods: The patient group consisted of 41 children aged 6–12 years, first diagnosed with ADHD and the control group consisted of 34 age- and gender- matched children.
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Conclusion & Impact:Results: HO-1 levels in the patient group were significantly lower than in the control group, while KEAP1 levels were significantly higher, but no significant difference was observed between the groups in terms of NRF2 (p=0.041, p
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Objective: The purpose of this study was therefore to evaluate serum heme oxygenase-1 (HO-1), kelch-like ECHassociated protein 1 (KEAP1), and nuclear factor erythroid 2 related factor 2 (NRF2) levels in children with attention deficit hyperactivity disorder (ADHD) and to reveal their association with the severity of ADHD. Methods: The patient group consisted of 41 children aged 6–12 years, first diagnosed with ADHD and the control group consisted of 34 age- and gender- matched children. ADHD was diagnosed by child psychiatrists during clinical interviews based on the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5). The parents of the children in the ADHD group were also given the Turgay DSM-IV-based Disruptive Behavior Disorders Child and Adolescent Rating and Screening Scale (T-DSM-IV-S). Serum HO-1, KEAP1, and NRF2 levels were determined in the biochemistry laboratory using the ELISA technique. Results: HO-1 levels in the patient group were significantly lower than in the control group, while KEAP1 levels were significantly higher, but no significant difference was observed between the groups in terms of NRF2 (p=0.041, p

Özet

Amaç: Bu çalışmanın amacı, dikkat eksikliği hiperaktivite bozukluğu (DEHB) olan çocuklarda serum heme oksijenaz-1 (HO-1), kelch benzeri ECH ile ilişkili protein 1 (KEAP1) ve nükleer faktör eritroid 2 ile ilişkili faktör 2 (NRF2) düzeylerini değerlendirip, bozukluğun şiddeti ile ilişkilerini ortaya koymaktır. Yöntem: Hasta grubu 6-12 yaşları arasında 41 DEHB’li çocuktan, kontrol grubu ise yaş ve cinsiyet açısından eşleştirilmiş 34 çocuktan oluşmaktadır. Zihinsel Bozuklukların Tanısal ve İstatistiksel El Kitabı, Beşinci Baskı (DSM-5) temel alınarak yapılan klinik görüşmeler sırasında DEHB tanısı çocuk psikiyatristleri tarafından konmuştur. DEHB’li çocukların ailelerine de Turgay DSM-IV Tabanlı Yıkıcı Davranış Bozuklukları Çocuk ve Ergen Derecelendirme ve Tarama Ölçeği (T-DSM-IV-Ö) verilmiştir. ELISA tekniği kullanılarak biyokimya laboratuvarında serum HO-1, KEAP1 ve NRF2 düzeyleri belirlendi. Bulgular: Hasta grubundaki HO-1 düzeyleri kontrol grubuna göre anlamlı derecede düşükken, KEAP1 düzeyleri anlamlı derecede yüksek bulundu, ancak NRF2 açısından gruplar arasında anlamlı fark gözlenmedi (p=0.041, p

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Cite This Article

AYAYDIN, H., KOYUNCU, İ., ÇELİK, H., KİRMİT, A., AKALTUN, İ., TAKATAK, H. (2022). Low HO-1 and High KEAP1 Serum Levels in Children with Attention Deficit Hyperactivity Disorder: The First Clinical Study. Anadolu Psikiyatri Dergisi, Cilt: 21 - Sayı: 3, 319–326. https://ajindex.com/articles/437846

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