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Journals / Akdeniz Tıp Dergisi / 2022 / Cilt: 8 - Sayı: 3

Evaluation Of Vitamin D Receptor Level In Hematopoetic Cells And Inflammatory Markers In Stage 3-5 Chronic Renal Patients

Evre 3-5 Kronik Böbrek Hastalarında Hematopoetik Hücrelerdeki Vitamin D Reseptör Düzeyi İle İnflamasyon Belirteçlerinin Değerlendirilmesi

Onur Yazdan BALÇIK
Feyza BORA
Sadi KÖKSOY
Fettah Fevzi ERSOY
Pages
333–341
Publication Date
2022-10-11
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Patients were divided into groups with a diagnosis of Vitamin D deficiency (

📌 3 Key Takeaways

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Objective & Hypothesis:Objective: In this study, we aimed to compare the relationship of vitamin D replacement with the percentage of vitamin D receptor (VDR) in CD3+, CD4+, CD8+ and CD14+ hematopoietic cells and inflammatory markers in stage 3-5 CKD patients.
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Key Findings & Data:Method: In this prospective study, 81 stage 3-5 (not on renal replace- ment treatment) CKD patients with estimated glomerular filtration rate (eGFR)≤60ml/min/1.73m2 were included.
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Conclusion & Impact:Patients were divided into groups with a diagnosis of Vitamin D deficiency (
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Objective: In this study, we aimed to compare the relationship of vitamin D replacement with the percentage of vitamin D receptor (VDR) in CD3+, CD4+, CD8+ and CD14+ hematopoietic cells and inflammatory markers in stage 3-5 CKD patients. Method: In this prospective study, 81 stage 3-5 (not on renal replace- ment treatment) CKD patients with estimated glomerular filtration rate (eGFR)≤60ml/min/1.73m2 were included. Serum creatinine, eGFR, intact parathormone (iPTH), 25 OH Vitamin D3 levels, CRP, neutrophil, lymphocyte values and VDR percentages in CD3+,CD4+,CD8+,CD14+ hematopoi- etic cells were calculated. Patients were divided into groups with a diagnosis of Vitamin D deficiency (

Özet

Amaç: Bu çalışmada, evre 3-5 kronik böbrek hastalarında (KBH) vitamin D replasmanının CD3+,CD4+, CD8+ ve CD14+ hematopoietik hücre alt gruplarındaki vitamin D reseptör (VDR) yüzdesi ile inflamatuar belirteçlerle ilişkisini değerlendirmeyi amaçladık. Yöntem: Bu prospektif çalışmada evre 3-5 KBH 'sı olan renal replasman tedavisi almayan; tahmini glomerüler filtrasyon hızı (tGFH) ≤60ml/dk/1,73m2 olan 81 hasta katıldı. Serum kreatinin, tGFH,intakt parathormon (iPTH), 25 OH vitamin D düzeyleri, CRP, nötrofil, lenfosit değerleri veCD3+, CD4+, CD8+, CD14+ hematopoietik hücrelerde VDR yüzdeleri hesaplandı. Hastalar, 25OH VD3 düzeylerine göre Vitamin D eksikliği tanısıyla (

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Cite This Article

BALÇIK, O. Y., BORA, F., KÖKSOY, S., ERSOY, F. F. (2022). Evaluation Of Vitamin D Receptor Level In Hematopoetic Cells And Inflammatory Markers In Stage 3-5 Chronic Renal Patients. Akdeniz Tıp Dergisi, Cilt: 8 - Sayı: 3, 333–341. https://ajindex.com/articles/434196

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