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Journals / Akademik Gastroenteroloji Dergisi / 2018 / Cilt: 17 - Sayı: 2

The utility of M30 and M65 antigen concentration levels for predicting degree of hepatic injury in patients with chronic hepatitis B infection

Kronik hepatit B enfeksiyonununda hepatik hasar düzeyinin öngörülmesinde M30 ve M65 antijen düzeylerinin etkinliği

Mustafa ÇELİK
Sezgin VATANSEVER
Belkıs ÜNSAL
Altay KANDEMİR
Pages
45–49
Publication Date
2022-10-11
DOI
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⚡ TL;DR(Too Long; Didn't Read)

The concentration of the M30 antigen was significantlyhigher in the chronic hepatitis B patient group than in thehealthy subject group (p 0.05).Correlation analysis performed in the patient group revealed a significantcorrelation between M30 antigen concentration levels and aspartateaminotransferase levels (r: 0.207, p

📌 3 Key Takeaways

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Objective & Hypothesis:Background and Aims: We aimed to determine the utility of M30and M65 antigen concentration levels for predicting hepatic injury inchronic hepatitis B disease.
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Key Findings & Data:Materials and Methods: This study comparedconcentration levels of M30 and M65 antigens between patientswith hepatitis B e-antigen negative chronic hepatitis B and healthysubjects.
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Conclusion & Impact:The concentration of the M30 antigen was significantlyhigher in the chronic hepatitis B patient group than in thehealthy subject group (p 0.05).Correlation analysis performed in the patient group revealed a significantcorrelation between M30 antigen concentration levels and aspartateaminotransferase levels (r: 0.207, p
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Background and Aims: We aimed to determine the utility of M30and M65 antigen concentration levels for predicting hepatic injury inchronic hepatitis B disease. Materials and Methods: This study comparedconcentration levels of M30 and M65 antigens between patientswith hepatitis B e-antigen negative chronic hepatitis B and healthysubjects. Furthermore, the correlations between either M30 or M65antigen levels and aspartate aminotransferase, alanine aminotransferase,HBV-DNA, histological activity index and fibrosis were evaluatedin the patient group. Results: A total of 81 subjects were included inthe study; 50 patients with HBeAg negative chronic hepatitis B and31 healthy subjects. The concentration of the M30 antigen was significantlyhigher in the chronic hepatitis B patient group than in thehealthy subject group (p 0.05).Correlation analysis performed in the patient group revealed a significantcorrelation between M30 antigen concentration levels and aspartateaminotransferase levels (r: 0.207, p

Özet

Giriş ve Amaç: Tüm hepatit türlerinde inflamatuvar olay nekroz ve apopitozu içeren farklı mekanizmalar ile hepatosit ölümüne sebep olur. M30-antijen apoptozis esnasında kaspazlar tarafından parçalanmış CK18 düzeylerini ölçmede, M65-antijen ise nekroza giden hücrelerden salgılanan total CK18 düzeylerini ölçmede kullanılır. Bu iki marker’ın kronik hepatit B enfeksiyonunda kullanımı ile ilgili sınırlı sayıda çalışma mevcuttur. Biz bu çalışmada M30 ve M65 antijen düzeylerinin, kronik hepatit B hastalığında karaciğer hasarını göstermede kullanılabilir olup olmadığını göstermeyi amaçladık. Gereç ve Yöntem: Bu çalışmada, Katip Çelebi Üniversitesi, İzmir Atatürk Eğitim ve Araştırma Hastanesi, Gastroenteroloji polikliniğine başvuran kronik hepatit B enfeksiyonlu hastalar ve sağlıklı kontrol grubunda, M30 ve M65 antijen düzeyleri ölçüldü ve çalışma sonunda elde edilen veriler karşılaştırıldı. Kronik aktif hepatit B enfeksiyonlu hastalarda ve sağlıklı kontrol grubunda M30 ve M65 antijen düzeyleri karşılaştırıldı. Ayrıca hasta grupta M30-M65 düzeyleri ile aspartat aminotransferaz, alanin aminotransferaz, hepatit B virus DNA, histoloji aktivite indeksi ve fibrozis düzeyleri arasındaki ilişki değerlendirildi. Bulgular: Çalışmaya 50 kronik aktif hepatit B hastası ve 31 sağlıklı kontrol olmak üzere toplam 81 hasta alındı. Hepatit B hasta grubunda M30-antijen düzeyi kontrol grubuna göre anlamlı düzeyde yüksek bulundu (p0.05). Hasta grupta yapılan korelasyon analizinde M30-antijen ile aspartat aminotransferaz arasında (r:0.207, p

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Cite This Article

ÇELİK, M., VATANSEVER, S., ÜNSAL, B., KANDEMİR, A. (2022). The utility of M30 and M65 antigen concentration levels for predicting degree of hepatic injury in patients with chronic hepatitis B infection. Akademik Gastroenteroloji Dergisi, Cilt: 17 - Sayı: 2, 45–49. https://ajindex.com/articles/432458

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