AI Summary & Key Takeaways
AI InsightThe mean BNP level of patients with pathological cranial CT was significantly higher than mean BNP levels of patients with normal cranial CT and patients in the control group (p
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Abstract
Background: Brain natriuretic peptide (BNP) is secreted by cardiac ventricles in response to increased wall stress and intraventricular volume but it was showed that there was some immunoreactivity of BNP in the human brain including cerebral cortex, thalamus, pons, and cerebellum. Aim: The aim of this study is to investigate the diagnostic value of bedside measurement of BNP that is used in order to predict the presence of intracranial pathologies in patients with head trauma. Materials and Methods: This study was performed prospectively with head trauma patients. Bedside BNP measurements and cranial computed tomography (CT) scans were performed in these patients. Results: The mean BNP level of 23 patients with pathologic cranial CT scan was 16.16±15.8 pg/mL and the mean BNP level of 17 patients with normal cranial CT scan was 5.78±3.0 pg/mL. It was 6.91±3.2 pg/mL in the control group. The mean BNP level of patients with pathological cranial CT was significantly higher than mean BNP levels of patients with normal cranial CT and patients in the control group (p
Özet
Giriş: Brain natriüretik peptit (BNP) kalpte artmış duvar gerilimi, duvar basıncı ve intraventriküler volüme sekonder olarak kardiyak ventriküllerden salınır. Ancak, insan beyninde serebral korteks, hipotalamus, talamus, pons ve serebellumda da immünreaktif yöntemle tespit edilmiştir. Amaç: Bu çalışmanın amacı, kafa travmalı hastalarda kafa içi yaralanmaların belirlenmesinde yatak başı BNP ölçümünün tanısal değerini araştırmaktır. Gereç ve Yöntemler: Çalışma kafa travmalı hastalarla prospektif olarak yapıldı. Bu hastalara bilgisayarlı beyin tomografisi (BBT) çekildi ve yatak başı BNP ölçümü yapıldı. Bulgular: BBT’sinde intrakraniyal lezyon olan 23 hastanın ortalama BNP düzeyi 16.16±15.8 pg/mL, intrakraniyal lezyon olmayan 17 hastanın ortalama BNP düzeyi 5.78±3.0 pg/mL olarak bulundu. Kontrol grubunda ortalama BNP düzeyi ise 6.91±3.2 pg/mL idi. Yapılan istatistiksel analiz sonucu intrakraniyal patoloji tespit edilen grubun BNP düzeyi diğer iki gruba göre anlamlı derecede yüksek bulundu (p