AI Summary & Key Takeaways
AI InsightIn the present study, we report a case who was brought to our hospital unconscious with meningoencephalitis and who, following prolonged prognosis efforts, was determined to have developed neurotoxicity, recurring seizures, and hepatotoxicity due to attempted suicide by ingestion of a potentially lethal dose (300 mg INH*50 tablets; 15 gr) of isoniazid. (JAEM 2011; 10: 43-5)
📌 3 Key Takeaways
Abstract
Antituberculosis drug-induced intoxications, though at a diminished level, could still rarely occur in the present day. İsoniazid-induced seizures, hepatotoxicity, and neurotoxicity have been reported, usually as chronic side eff ects. In the present study, we report a case who was brought to our hospital unconscious with meningoencephalitis and who, following prolonged prognosis efforts, was determined to have developed neurotoxicity, recurring seizures, and hepatotoxicity due to attempted suicide by ingestion of a potentially lethal dose (300 mg INH*50 tablets; 15 gr) of isoniazid. (JAEM 2011; 10: 43-5)
Özet
Antitüberküloz ilaçlara bağlı zehirlenmeler günümüzde azalmış olmakla beraber nadir de olsa görülebilmektedir. İzoniazide bağlı nöbet, hepatotoksisite ve nörotoksisite bildirilmiş olup, genelde kronik yan etkiler olarak rapor edilmiştir. Bu çalışmamızda şuuru kapalı, meningoensefalit nedeni ile sevk edilen ve uzun süre tanı çalışmalarından sonra intihar amaçlı yüksek dozda (300 mg İNH*50 tane tablet; 15 gr) izoniazid alınımına bağlı nörotoksisite, tekrarlayan nöbetler ve hepatotoksisite olduğunu tespit ettiğimiz bir vakayı sunmak istiyoruz. (JAEM 2011; 10: 43-5)